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Articles by M.S. Abubakar
Total Records ( 3 ) for M.S. Abubakar
  A.B. Sallau , G.C. Njoku , A.R. Olabisi , A.U. Wurochekke , A.A. Abdulkadir , Shehu Isah , M.S. Abubakar and S. Ibrahim
  Aqueous extract of Guiera senegalensis leaves was investigated for the inhibitory action on the activity of crude phospholipase and metalloprotease enzymes from Echis carinatus venom. Both enzymes were inhibited by the extract in a dose dependent fashion. Double reciprocal plots of the initial velocity data of the inhibition by the extract revealed a non-competitive pattern of inhibition for the metalloprotease and a competitive one for the phospholipase. Extrapolated Ki values were found to be 11.9 and 90 μg mL-1 for the metalloprotease and phospholipase, respectively.
  L.J. Hamidu , J.O. Ayo , A.B. Adelaiye and M.S. Abubakar
  This study evaluated the central action of Waltheria indica extract. Aqueous ethanolic extract of the plant showed bioactivity in acetic-acid induced stretches in animal model. The central effects of the most biologically active fraction (ethyl acetate) of extract of Waltheria indica was evaluated in mice using the elevated plus maze paradigm and the strychnine and leptazol-induced convulsions. Sedative effect was studied using the amylobarbitone-induced sleeping time. The extract fraction significantly (p< 0.05) increased the amylobarbitone sleeping time and protected (100%) mice from death due to pentylenetetrazole convulsion. The extract failed to protect mice against strychnine convulsion, even though it delayed the time of onset of death. The exploratory activity was also significantly (p< 0.05) decreased in the extract treated mice. The extract blocked leptazole-induced convulsion, potentiated amylobarbitone sleeping time and decreased exploratory activity, indicating anticonvulsant and sedative actions.
  S.F. Ambali , M. Mamman , A.O. Adaudi , K.A.N. Esievo , J.O. Ayo and M.S. Abubakar
  The aim of this study is evaluate the curative and protective effects of penicillin G in mice poisoned with the lyophilized extract of Chlorophyllum molybdites. Fifty Swiss albino mice were divided into 5 groups of 10 mice each. Mice in group 1 were pretreated with penicillin G at 38, 280 IU kg-1, i.p. and then dosed with LD99 of C. molybdites (741 mg kg-1) i.p., mice in group 2 were dosed with the extract and then treated with penicillin G, while mice in group 3 were dosed with the extract only. Mice in groups 4 and 5 were dosed with penicillin G and physiological saline solution, respectively. The mice were monitored for clinical signs of toxicity, pathological lesions and death over a period of 72 h. The mean time of death in mice from penicillin-treated groups 1 and 2 were compared with those in the extract-treated group using one-way analysis of variance (ANOVA) and values of p<0.05 were considered significant. The result showed a significant reduction in the severity of clinical signs and mortality in penicillin-treated groups 1 and 2 compared to the group dosed with only the extract. There was a significant difference in the mean time of death in mice from groups 1, 2 and 3. However, there was no reduction in the severity of lesions in mice from groups 1 and 2 treated with penicillin G compared with extract-treated group. Therefore, this study has shown that penicillin G has significant curative and protective effects in mice poisoned with the lyophilized extract of C. molybdites. This result may prove useful in the treatment of humans and animals suffering from C. molybdites poisoning.
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