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Articles by M.P. Balasubramanian
Total Records ( 2 ) for M.P. Balasubramanian
  S. Selva Kumar , M. Ram Krishna Rao and M.P. Balasubramanian
  To aim at providing an alternative, cheap and effective medicine for fibrosarcoma this study was undertaken. Indian folk medicine comprises numerous prescriptions for therapeutic purposes which may be as varied as ulcers, leprosy and cancer. The antineoplastic effect of the aqueous extracts of Indigofera aspalathoides on 20-methylcholanthrene (20-MCA) induced fibrosarcoma was investigated in the male albino rats. The levels of non-protein nitrogenous compounds such as urea, uric acid and creatinine, the levels of lysosomal enzymes such as N-acetyl β-D-glucuronidase and the levels of gluconeogenic enzymes such as glucose 6-phosphatase and fructose 1, 6-diphosphatase were used to monitor the antineoplastic potentials of Indigofera aspalathoides. Fibrosarcoma was induced in Wister strain of male albino rats by subcutaneous implantations of Millipore filter discs impregnated with 5% suspension of 20-MCA in paraffin oil and the tumors appeared in about 4 weeks. The fibrosarcoma was proved by pathological examinations. Intra-peritoneous (i.p.) administration of 250 mg kg-1 b.wt. Aqueous extracts of Indigofera aspalathoides for 30 days effectively suppressed the 20-MCA induced chemical carcinogen, revealed by the reduced incidence of fibrosarcoma. The levels of non protein nitrogenous compounds such as urea, uric acid and creatinine, the levels of lysosomal enzymes and the levels of gluconeogenic enzymes in liver and kidney samples were significantly altered. The findings clearly indicate the antineoplastic potentials of Indigofera aspalathoides on 20-MCA induced fibrosarcoma in rats.
  S.S. Kumar , M.R.K. Rao and M.P. Balasubramanian
  Cancer is a ubiquitous disease. Multidisciplinary scientific investigation is making best efforts to combat this disease but the sure shot perfect cure is yet to be brought into the world of medicine. The complementary and alternative medicines such as Siddha and Ayurveda have been the basis of treatment and cure for various diseases and physiological abnormalities in traditional methods under practice. Indian folk medicine comprises of numerous prescriptions for therapeutic purposes which may be as varied as ulcer, leprosy, skin infections and cancer. The anticancer effects of the aqueous extract of Indigofera aspalathoides on 20-Methylcholanthrene induced fibrosarcoma were investigated in male albino rats. Fibrosarcoma was induced by subcutaneous implantation of Millipore filter disc impregnated with 5% suspension of 20-Methylcholanthrene, in paraffin oil and the tumors appeared in about six weeks. The fibrosarcoma was isolated and proved by pathological examinations. Intraperitoneous (i.p.) administration of 250 mg kg-1 b.wt. per day of aqueous extract of Indigofera aspalathoides for 30 days effectively suppressed the 20 Methylcholanthrene induced chemical carcinogenesis as revealed by the reduced incidence of fibrosarcoma in control and experimental animals. The levels of lipid peroxidation and non enzymatic antioxidants such as reduced glutathione, Vitamin C, Vitamin E and total thiols in liver and kidney of control animals were significantly altered. These findings clearly indicate that the antineoplastic efficacy of Indigofera aspalathoids on 20 Methlycholanthrene induced fibrosarcoma on male albino rats.
 
 
 
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