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Articles by M.N. Ansari
Total Records ( 2 ) for M.N. Ansari
  M.K. Anwer , S. Jamil , M. Ahmad , M.N. Ansari and T.H. Khan
  This study was performed on the possibility of novel complexing agent/bioavailability enhancer in the form of complexation of aspirin with fulvic acid. Solid complexes of aspirin-fulvic acid prepared by solvent evaporation, freeze drying and spray drying methods. These complexes were characterized by using differential scanning calorimetry, fourier transform infrared spectroscopy, powder X-ray diffractometry and scanning electron microscopy. In addition, the influences of the fulvic acid on the dissolution, permeation, stability and pharmacodynamics profile of the complexes were studied. In vitro dissolution studies confirmed the successful complexation by the spray drying method in a molar ratio of 1: 1. The prepared optimized complex showed an improvement in stability and permeability (8 times as compared to pure drug). A significant (p<0.05) anti-inflammatory action of the treatment of optimized spray dried (1:1) aspirin complex with fulvic acid was evidenced by inhibition of rat paw edema and anti-ulcerogenic action was measured by lowest score of ulcer index (0.480.08) with significant reduction in ulceration as compared to pure drug. Fulvic acid appears to be beneficial to overcome the problem of stability and bioavailability of aspirin. A highly significant anti-inflammatory and anti-ulcerogenic action was observed by the treatment of optimized complex. Technology has been developed which can be used for improvement formulation of aspirin.
  M. Ahmad , M.N. Ansari , A. Alam and T.H. Khan
  Diabetic patients wound healing is slower than the healthy individuals. Three citrus peel extracts; Lemon (Citrus limon), Grapes fruits (Citrus paradise) and Orange (Citrus sinensis) promote wound healing in experimental animals. This study investigated the effect of oral treatment with citrus peel extracts on wound repair of the skin of diabetic rats. The extracts were estimated for vitamin C and total carotenoid contents prior to animal study. Diabetes mellitus was induced in rats by intraperitoneal injection of a single dose of streptozotocin (STZ, 75 mg kg-1 b.wt.). One week after diabetes induction, full thickness excision wounds were made in hyperglycemic rats and were divided groups, each containing 6 rats. The different test group animals were treated with different citrus peel extract orally at the dose of 400 mg kg-1 body weight daily for 12 days. The blood glucose, body weight and rate of wound closure of each rat were measured every 3rd day during the experimental period. At the end of experiment, granular tissues of wounds were removed and estimated for hydroxylproline and total protein content. The results showed significant reduction in blood glucose and time to wound closure. Tissue growth and collagen synthesis were significantly higher as determined by total protein and hydroxyl proline content. From our experimental data, we propose that oral administration of citrus peel extracts has a therapeutic potential in the treatment of chronic wounds in diabetes.
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