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Articles by M.M. Suleiman
Total Records ( 2 ) for M.M. Suleiman
  M.U. Kawu , L.S. Yaqub , J.O. Ayo , P.I. Rekwot , B. Habibu , M. Tauheed , M.M. Suleiman , M. Shittu , T. Aluwong , H.I. Isa and A. Abdullahi
  The aim of this study was to evaluate the features of induced abortion and post-abortion oestrous cycles pattern following treatment with prostaglandin F (PGF) in Sokoto Red (SR) goats. Twelve apparently healthy goats made up of 6 pregnant and 6 non-pregnant (cycling) does were used for the study. Each doe was given a single intramuscular injection of 7.5 mg PGF. All the 6 pregnant does treated with PGF aborted within 72.0±12.4 h post-treatment. Of the 6 does that aborted, 5 (83.3%) showed oestrus subsequently while 4 (66.7%) out of the 6 non-pregnant does were induced to oestrus. Time interval to induced oestrus was 129.6±36.1 and 50.0±11.5 h for the aborted and non-pregnant does, respectively. Mean duration of oestrus for the aborted and non-pregnant does was 46.9±9.6 and 38.7±4.3 h, respectively. The first and second post-abortion oestrous cycle lengths were 6.5±0.5 and 12.5±8.5 days, respectively. While the first and second post-treatment cycle lengths in the non-pregnant does was 22.5±1.2 and 21.3±0.3 days, respectively. It is concluded that a single dose of 7.5 mg PGF is sufficient to induce abortion and oestrus simultaneously in SR goats. However, the post-abortion cycles are short.
  S.A. Babalola , M.M. Suleiman , A.Z. Hassan and D.A.Y. Adawa
  This study evaluates the methanolic crude extract of Datura metel L. seeds (family Solanaceae) as a potential oral anaesthetic in dogs. Following the oral acute toxicity study to determine the median Lethal Dose (LD50) of the extract in twelve (12) mice, the extract was relatively safe since when administered at the highest dose (5,000 mg kg-1) no sign of toxicity and no death was recorded. In the in vivo sedative and anaesthetic study of the effect of Datura metel L. in this research, the observed pharmacological effect of the extract administered orally to 5 dogs separately at a dose rate of 0.6, 1.2, 1.5, 2 and 2.4 g kg-1, respectively during establishment of a suitable pilot oral anaesthetic doses, showed a graded dose response relationship. The extract at an oral dose of 2.4 g kg-1 induced surgical anaesthesia in dogs with increased heart and respiratory rates (107-205 bpm and 36.33-41.33 cpm), respectively, normal rectal temperature (37.83°C), adequate tissue perfusion, good muscle relaxation but poor analgesia, loss of anal sphincter tone and loss of pupillary reflex. The dogs recovered without any complications. This study has shown that the seed extract of Datura metel L. is relatively safe, induced sleep similar to that of thiopentone sodium anaesthesia with good anaesthetic indices at the oral dose rate of 2.4 g kg-1 in dogs.
 
 
 
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