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Articles by M.K. Abubakar
Total Records ( 2 ) for M.K. Abubakar
  R.A. Umar , S.W. Hassan , M.J. Ladan , M. Nma Jiya , M.K. Abubakar and U. Nata`ala
  The aim of this study was to evaluate the association of K76T mutation in Pfcrt gene and chloroquine treatment failure following reports that the efficacy of chloroquine in the treatment of uncomplicated falciparum malaria in Africa is seriously compromised by high levels of drug resistance. The occurrence of mutation on codon 76 of Plasmodium falciparum chloroquine resistance transporter (Pfcrt) gene has been associated with development of resistance to chloroquine. We investigated the association of K76T mutation in Pfcrt gene in malaria-infected blood samples from a cohort of Nigerian children with uncomplicated falciparum malaria treated with chloroquine and its association with clinical (in vivo) resistance. The Pfcrt T76 allele was very significantly associated with resistance to chloroquine (Fischer exact test: p = 0.0001). We conclude that K76T mutation in Pfcrt gene is significantly associated with chloroquine resistance and that it could be used as a population marker for chloroquine resistance in this part of the country.
  R.A. Umar , S.W. Hassan , M.J. Ladan , M. Nma Jiya , I.K. Matazu , M.K. Abubakar , U. Nata`ala and K. Abdullahi
  In a prospective cross sectional study, the therapeutic efficacy of chloroquine was assessed in children under the age of five years with uncomplicated P. falciparum malaria in Sokoto, Nigeria, using the in vivo 14 day World Health Organization`s protocol (with some modifications). One hundred and twenty six children aged 2 to 59 months were enrolled, out of which 108 completed the study. Clinical, parasitological and haematological data at study start and end were obtained by standard methods. Children were treated with 25 mg kg-1 body weight over 3 days. Adequate clinical and parasitological response was 72.2%, clinical failure was 23.27 and total treatment failure 27.8%. Because of unacceptably high rate of treatment failures due to diminishing efficacy, chloroquine cannot remain the recommended first line drug for the treatment of P. falciparum malaria in pre-school children in Nigeria and the antimalarial treatment policy change from chloroquine to Artemisin-based combination was necessary and justified. Challenges to the success of the policy for control of malaria morbidity and mortality were discussed.
 
 
 
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