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Articles by M.J. Ladan
Total Records ( 5 ) for M.J. Ladan
  R.A. Umar , S.W. Hassan , M.J. Ladan , I.K. Matazu , M. Nma Jiya and H.O. Usman
  Retrospective analysis of the results of haemoglobin genotyping of 1033 cases was conducted at the Haemoglobin Genotyping Laboratory in Sokoto, Nigeria. Haemoglobin genotype determination was performed by cellulose acetate electrophoresis. The results show that 666 (64.5%) were Hb AA, 241 (23.3%) Hb AS, 117 (11.3%) Hb SS, 5.0 (0.48%) Hb AC 2.0 (0.19%) and Hb SC 2.0 (0.19%). We conclude that the prevalence of genes for these haemoglobin variants could be explained on the basis of selection due to evolutionary pressure imposed by malaria in line with malaria theory and theory of balanced polymorphism. The implication of our findings on health care provision and planning in the region is discussed.
  K.J. Umar , L.G. Hassan , S.M. Dangoggo and M.J. Ladan
  Analyses of the nutritional composition of water spinach (Ipomoea aquatica) Forsk leaves were carried out using standard methods of food analysis. The proximate composition as well as mineral elements were determined. The leaves were found on dry weight basis to have high moisture (72.83±0.29%), ash (10.83±0.80%), crude lipid (11.00±0.50%), crude fibre (17.67±0.35%) and available carbohydrate (54.20±0.68%), but low in crude protein content (6.30±0.27%). The leaves also have energy value (300.94±5.31 kcal/100 g) that is within the range reported in some Nigerian leafy vegetables. The mineral element contents were high with remarkable concentration of K (5,458.33±954.70 mg/100 g) and Fe (210.30±2.47 mg/100 g). Also the leaves content moderate concentrations of Na (135.00±2.50 mg/100 g), calcium (416.70±5.77 mg/100 g), Magnesium (301.64±12.69 mg/100 g) and P (109.29±0.55 mg/100 g), with low Cu (0.36±0.01 mg/100 g), Mn (2.14±0.22 mg/100 g) and Zn (2.47±0.27 mg/100 g) contents. Comparing the mineral content with recommended dietary allowance, it was showed that the plant leaves is good sources of K, Mn and Fe for all categories of people, while Mg is adequate enough for adult female and children. From the result, Ipomoea aquatica Forsk leaves could be used for nutritional purposes, due to the amount and diversity of nutrients it contains.
  S.W. Hassan , M.J. Ladan , R.A. Dogondaji , R.A. Umar , L.S. Bilbis , L.G. Hassan , A.A. Ebbo and I.K. Matazu
  The leaves of Erythrophleum africanum is known in the arid land of tropical Africa to posses toxicological properties. Phytochemical, acute and sub-acute evaluation of the possible toxicity risk of E. africanum aqueous leaves extracts were investigated in this study. Phytochemical constituents detected in the leaves extracts were saponins (1.16% w/v), cardiac glycosides, tannins (0.17 true tannins and 0.23% w/v pseudotannins), flavonoid glycosides, free flavonoids and alkaloids (4.34% w/v). The Lethal Dose (LD50) of the aqueous leaves extracts was greater than 3000 mg kg-1 per os (orally) in albino rats. Sub-acute administration of the extract for 28 days resulted in significant (p<0.05) changes in some renal and liver indices at 3000 and 2000-3000 mg kg-1 body weight, respectively. Histopathological lesions of the kidney and liver in form of moderate and marked infiltration with necrosis and perivascular lymphocytic cuff were observed. The observed lesions could be due to roles played by liver and kidneys in metabolism of xenobiotics and their elimination from the body. These investigations thus seem to indicate the toxic effects of the aqueous leaves extracts of E. africanum at 2000-3000 mg kg-1. These could be attributed to the combined toxicity of the phytochemical constituents such as tannins, saponins, glycosides and alkaloids.
  S.W. Hassan , F.L. Bilbis , M.J. Ladan , R.A. Umar , S.M.Dangoggo , Y. Saidu , M.K. Abubakar and U.Z. Faruk
  The aqueous and organic solvents extracts of leaves, stem barks and roots of Calotropis procera were screened for antifungal (agar dilution method) and phytochemical properties. Organic solvents extracts of the stem bark significantly (p<0.05) inhibited growth of Trichophyton rubrum and Microsporum gypseum. The petroleum ether (PE) extract however was significantly (p<0.05) active on only Trichophyton rubrum at concentrations ranging from 0.66 to 5.33 mg mL-1. All the leave extract fractions completely inhibited the growth of the tested organisms. The roots fractions of hexane (HX) and PE extracts showed significant (p<0.05) growth inhibitions of Microsporum gypseum and Aspergillus niger. All the aqueous extract fractions of the plant parts showed complete growth inhibition of all the tested organisms. Alkaloids, flavonoids, tannins, steroids, triterpenoids, saponins and saponin glycosides were detected in the leaves and roots extract fractions, with only flavonoids, triterpenoids and saponins in the stem bark extracts. The results obtained lend scientific credence for the use of the plant against fungal diseases.
  R.A. Umar , N.M. Jiya , M.J. Ladan , M.K. Abubakar , S.W. Hassan and U. Nata`ala
  We surveyed for the prevalence of anaemia, by packed cell volume and haemoglobin determinations, in a cohort of 36 pre-school children with uncomplicated Falciparum malaria in Sokoto, Nigeria. By packed cell volume, 5 (3.9%) of the children were mildly anaemic, 3 (8.3%) were moderately anaemic and 28 (77.8%) were normal. As indicated by haemoglobin levels, 6.0 (16.67%) of the study children have moderate anaemia while the remaining 30 (83.3%) were normal. There was no incidence of severe anemia in the study cohort. Comparison of Hb with PCV methods for anaemia detection indicates that the latter is more efficient in detecting prevalence of anaemia in our study subjects. Peak incidence of mild anaemia occurred in the age groups 0-12 and 49-60 months, with the lowest incidence occurring in age group 37-48 months. Peak and lowest incidence of moderate anaemia occurred in the age group 13-24 and 0-12 months, respectively. Haemoglobin levels did not vary significantly among the age groups (ANOVA, F = 1.006, p = 0.4194). Although all children less than five years of age in this setting are at risk for anaemia, the age group 13-24 months should be especially monitored for anti-anaemia interventions.
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