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Articles by M.I. Kazeem
Total Records ( 2 ) for M.I. Kazeem
  M.A. Akanji , M.T. Yakubu and M.I. Kazeem
  The aim of this study was to investigate the hypolipidemic potential of aqueous extract of Rauvolfia vomitoria root and assess its toxicological effect in selected tissues of rats. Aqueous extract of Rauvolfia vomitoria root was administered to wistar rats daily at 24 h interval at a dosage of 200 mg kg-1 b.wt. following which the rats were sacrificed after receiving 1, 3, 5, 10, 20 and 30 daily oral doses. Administration of the extract produced significant reduction (p<0.05) in the concentration of the Low-density Lipoprotein Cholesterol (LDL-C), triglyceride and atherogenic indices while a dose-dependent significant increase (p<0.05) occurred in the High-density Lipoprotein Cholesterol (HDL-C) concentration. Significant changes were also observed (p<0.05) in the activities of alkaline phosphatase (ALP) and acid phosphatase (ACP) in all the tissues studied except small intestine. There were significant fluctuations (p<0.05) in the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the tissues except in the kidney. The results suggest that aqueous extract of Rauvolfia vomitoria root possesses hypolipidemic potential but caused alterations in the concentration of the enzymes studied and so may not be completely safe at the dose used in this study.
  M.I. Kazeem , T.V. Dansu and S.A. Adeola
  In recent decades, there has been a drastic increase in the incidence and prevalence of diabetic mellitus. The aim of this study was to evaluate the in vitro inhibitory effect of Azadirachita indica leaf extract on the activity of α-amylase and α-glucosidase as a means of alleviating hyperglycemia and managing diabetes mellitus. Aqueous extract of Azadirachita indica exhibited most potent α-amylase inhibitory activity with IC50 value of 9.15 mg mL-1 and acetone extract exhibited most potent α-glucosidase inhibitory activity with IC50 value of 5.00 mg mL-1. Kinetic studies revealed both acetone and aqueous extract to exhibit mixed non-competitive inhibition for α-amylase and α-glucosidase. It can be concluded that the antidiabetic potential of Azadirachta indica may be due to its ability to inhibit both α-amylase and α-glucosidase. The presence of phytochemicals such as flavonoids, tannins and saponins in this plant may be responsible for its inhibitory activity on the two enzymes studied.
 
 
 
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