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Articles by M.I. Akpanabiatu
Total Records ( 8 ) for M.I. Akpanabiatu
  F.E. Uboh , M.I. Akpanabiatu , I.J. Atangwho , P.E. Ebong and I.B. Umoh
  The effect of vitamin A on weight-loss, growth-depression and haematotoxicity associated with gasoline vapours exposure was assessed in male and female Wistar albino rats. The rats were exposed to ungraded concentrations of gasoline vapours (6 h daily) for 20 weeks. Vitamin A (retinol) at prophylactic dosage (400 IU kg-1 day-1) was orally administered to the rats in the last two weeks of exposure. The levels of haemoglobin (Hb), haematocrit or Packed Cell Volume (PCV), Red Blood Cells (RBC), weight gain and growth rate in the male and female rats exposed to the vapours were significantly lower (p<0.05) compared respectively to the levels obtained for male and female control rats. On the other hand, the levels of White Blood Cells (WBC) in the male and female test rats were significantly higher (p<0.05) compared respectively with the level obtained for male and female control rats. These observations indicated that exposure to gasoline vapours produced haematotoxicity, weight loss and growth depression in rats. However, administration of vitamin A was observed to produce a significant regain (p<0.05) in weight-loss, growth-depression and haematotoxicity observed to be associated with exposure to gasoline vapours, although the females were noted to respond more favourably than the males. This suggests that vitamin A may be used to reverse or prevent weight-loss, growth-depression and haematotoxicity in subjects exposed to gasoline vapours.
  F.E. Uboh , M.I. Akpanabiatu , Y. Alozie , E.E. Edet , J.I. Ndem and P.E. Ebong
  Comparative effect of vitamins A and E on gasoline vapours haematotoxicity, growth-depression and weight-loss was assessed in male Wistar albino rats. The rats were exposed to gasoline vapours (17.8±2.6 cm3/h/m3/day), 6 h/day, 6 days/week for 20 weeks. Vitamins A (retinol) and E(α-tocopherol) at prophylactic dosage (400 and 200 IU/kg/day, respectively) were orally administered to the rats separately, in the last 2 weeks of exposure. The levels of haemoglobin (Hb), haematocrit or Packed Cell Volume (PCV), Red Blood Cells (RBC), growth-rate and weight-gain in the rats exposed to the vapours were significantly lower (p<0.05) compared, respectively to the levels obtained for control rats. On the other hand, the levels of White Blood Cells (WBC) in the test rats were significantly higher (p<0.05) compared, respectively with the level obtained for male control rats. These observations indicate that exposure to gasoline vapours may cause haematotoxicity, growth-depression and weight-loss in male rats. However, administration of vitamins A and E was observed to produce a significant recovery (p<0.05) in haematotoxicity, growth-depression and weight-loss observed to be associated with exposure to gasoline vapours, although, the rats administered with vitamin E were noted to respond more favourably than those administered with vitamin A. This suggests that although retinol and α-tocopherol may be used to reverse or prevent haematotoxicity, growth-depression and weight-loss in subjects exposed to gasoline vapours, the reversal potency of α-tocopherol is higher than that of retinol.
  F.E. Uboh , M.I. Akpanabiatu and Y. Alozie
  The effect of gasoline vapours (17.8±2.6 cm3/h/m3/day) on renal functions was assessed from the total kidney weights and the levels of serum creatinine, urea and blood urea nitrogen (BUN) in male and female rats, following 64 days of exposure. The results showed an insignificant (p>0.05) increase in percentage kidney weight per total body weight (PKW/BW), decrease in total serum protein and a significant increase (p<0.05) in serum creatinine, urea and BUN levels in both male and female test rats, compared respectively with the control. However, the percentage changes in the PKW/BW, serum creatinine and urea levels obtained for female rats were observed to be significantly higher (p<0.05), compared to the respective percentage changes obtained for male rats. This observation indicates that frequent exposure to gasoline vapours may cause renal dysfunction in rats, with females at greater risk.
  F.E. Uboh , M.I. Akpanabiatu , I.J. Atangwho and Y. Alozie
  A gender-dependent potential atherosclerotic risk is reported in this study to be associated with exposure to gasoline vapours in rats model. The atherosclerotic risk was assessed from the serum lipid and some electrolytes (Na+, K+ and Cl¯) profiles in male and female rats exposed wholly to 17.8±2.6 cm3/h/kg/m3/day of gasoline vapours (8 h daily, 6 days week-1) for 20 weeks in exposure chambers. A significant increase (p<0.05) in serum total cholesterol (TC), triglycerides (TGs), Low Density Lipoprotein-Cholesterol (LDL-C), Very Low Density Lipoprotein-Cholesterol (VLDL-C), K+ and decrease (p<0.05) in High Density Lipoprotein-Cholesterol (HDL-C), Na+ and Cl- was obtained for both male and female rats exposed to gasoline vapours. These results showed a state of hyperkalaemia, hyponatraemia, increased TG/HDL-C ratio and Atherogenic Index of Plasma (AIP) in male and female rats exposed to gasoline vapours. However, the comparative percentage increase in serum TC, TGs, LDL-C, VLDL-C, K+, as well as percentage decrease in serum HDL-C, Na+ and Cl¯ reported to be associated with exposure to gasoline vapours, were observed to be significantly higher (p<0.05) in females than the male rats. Since hyperlipidaemia, hyperkalaemia and hyponatraemia are known to be implicated in atherosclerosis, the result of this study gives a clear indication that gasoline vapours is among the risk factors for atherosclerosis and that the females are more adversely affected than the males in rats model.
  E.E. Edet , M.I. Akpanabiatu , F.E. Uboh , T.E. Edet , A.E. Eno , E.H. Itam and I.B. Umoh
  The effect of Gongronema latifolium crude leaf extract (GL) on weight-loss, growth-depression and haematotoxicity was assessed in male diabetic rats. Normal and diabetic rats were gavaged with 200, 300 and 400 mg kg-1 b.wt. of GL day-1 for two weeks. The levels of haemoglobin (Hb), haematocrit or Packed Cell Volume (PCV), Red Blood Cells (RBC), white blood cells (WBC) and Platelet Count (PC) in Diabetic Rats (DR) were significantly higher, (p<0.05 for PCV%; p<0.001 for Hb, RBC, WBC and PC), compared, respectively to the levels obtained for the Non-Diabetic Rats (NDR). However, GL at dose levels of 200 and 400 mg kg-1 b.wt., respectively, caused significant decrease in the level of WBC in diabetic treated rats when compared to control. At 300 and 400 mg kg-1 b.wt., PCV% and WBC levels in NDR were significantly different (p<0.05 for both levels at 300 mg kg-1 b.wt.; p<0.05 and p<0.001 for PCV% and WBC at 400 mg kg-1 b.wt.) compared to their controls. The results also showed a significant decrease (p<0.001) in weight and growth-rate of diabetic test groups when compared to non-diabetic test groups following increased treatment with doses of GL. These observations indicated that diabetic condition produces alterations in haematological indices, weight-loss and growth-depression which may be reversed by treatment with GL at 400 mg kg-1 b.wt. in rat model. The significant (p<0.001) increase in WBC counts in alloxan-induced diabetic rats may likely be due to alloxan poisoning, which is in line with the normal physiological response following the perception of an insult to the body defense mechanisms. The results of this study suggest that GL may be used to reverse, prevent or reduce weight-loss, growth-depression and haematotoxicity in diabetic subjects.
  F.E. Uboh , M.I. Akpanabiatu , A.N. Aquaisua and Eno-obong I. Bassey
  Measurement of the levels of total protein, creatinine, uric acid, urea, Blood Urea Nitrogen (BUN), potassium (K+), chloride (Cl-), bicarbonate (HCO3-), sodium (Na+) and calcium (Ca2+) in the blood is useful in assessing the functional integrity of the renal tissues. In this study, the effect of oral exposure to 10, 20 and 30 mg kg-1 b.wt. of nitrocellulose thinner on these serum renal function indices and histopathology of the renal tissues was assessed. Twenty four adult male albino rats (120-150 g), divided into one control and three test groups of six rats each, were used in this study. The rats in the control group were administered with normal saline, while the graded concentrations of the nitrocellulose solvent were each administered orally, as a single daily dosage, for 30 days. The results showed that exposure to nitrocellulose thinner caused a significant (p<0.05) dose-dependent increase in the levels of serum creatinine, uric acid, urea, BUN and K+, as well as decrease in the levels of total serum protein, Cl-, HCO3- and Na+ in rat model. However, there was no significant (p>0.05) difference in serum Ca2+ levels obtained for the rats between and within the test groups, compared to the control. Also, the result of microscopic examinations showed a dose dependent histopathological damage to the renal tissues of rats exposed to nitrocellulose thinner. The observations made from the tissue microscopic analysis, in correlation with that of biochemical assay, indicated the existence of disturbances in the filtration function of the kidneys in rats exposed to higher dosages of the solvent. Hence, the results obtained from our biochemical and histopathogical findings suggested that nitrocellulose thinner possesses the potential (s) of inducing nephrotoxicity in rats.
  J.I. Ndem , M.I. Akpanabiatu and E.U. Essien
  Periwinkle (Tympanotonus fustcatus), Crayfish (cambarellus diminutus) and Bonka fish (Ethimalosa fimbriata) are local marine food sources of omega-3 fatty acid. Groundnut oil, corn oil and soybean oil are notably high in omega-6 fatty acids. The present study compared changes in haematological and biochemical indices in rats fed with local marine foods (periwinkle, bonka fish and crayfish) and vegetable oils (groundnut, soybean and corn oil) enriched meals. Rats in all the experimental groups had a significant (P< 0.05) increase in the Hb, PCV and RBC values and a non-significant decrease (P> 0.05) in the WBC counts, when compared with the control. The results of the lipid profile of the test groups on omega-3 and omega-6 enriched pellets were significantly lower than that of control but the HDL-C concentrations were significantly higher in these groups. Similarly rats on pellets enriched with local marine foods (periwinkle, bonka fish and crayfish) considered to be rich in omega-3 fatty acid had significant decreased (P < 0.05) cholesterol, and HDL – C concentrations while TG, VLDL and LDL-C increased significantly when compared with control. These results suggest that consumption of diet enriched with periwinkle, bonka fish, crayfish and oil rich in omega-3 and omega-6 polyunsaturated fatty acids may prevent cardiovascular disease. This may be one mayor reason for low incident of coronary heart disease among the poor rural people that consumed basically periwinkle, bonka fish and cray fish as their main sources of protein.
  Y. Alozie , M.I. Akpanabiatu , E.U. Eyong , I.B. Umoh and G. Alozie
  The crude protein contents and amino acid compositions of two varieties of Dioscorea dumetorum (edible and wild) were determined. The crude protein (g/l00g) of the wild variety (11.37) was significantly higher (P<0.05) than the edible variety (7.0). The amino acid profiles showed both varieties to be limiting in lysine, methionine and cystine. The wild variety had tryptophan (0.60g/100g total aa), phenylalanine (3.01g/100g total aa), threonine (2.93g/100g total aa) and valine (3.6g/100g total aa) in substantial amounts when compared to the reference FAO pattern. Aspartic acid (4.47-9.28/100g total aa) was the most abundant amino acid in both varieties with the highest amount recorded for the wild variety. The chemical scores of the essential amino acids were tryptophan (60.0), threonine (43.5), valine (39.6), methionine (28.0) isoleucine (34.5), leucine (32.0), tyrosine and phenylalanine (39.0) and lysine (20.72) for the edible and tryptophan (117.0), threonine (73.25), valine (72.0), methionine (54.0) isoleucine (64.75), leucine (65.71), tyrosine and phenylalanine (83.67) and lysine (44.18) for the for the wild variety. This results being the first amino acid profiles recorded for this yam suggests that the wild D. dumetorum is richer in amino acid content than the edible variety and is likely to be of more benefit in human and animal nutrition.
 
 
 
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