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Articles by M.G. Vashist
Total Records ( 1 ) for M.G. Vashist
  M.G. Vashist , S. Deswal , M. Verma and S. Kharb
  Deep Vein Thrombosis (DVT) affects a significant proportion of population and if untreated timely leads to high mortality due to pulmonary embolism. Though color Doppler ultrasonography is the gold standard for diagnosis but non availability of experienced radiologist especially at night has led to alternative investigation for diagnosis of DVT. Plasma D-dimer levels which measure the degradation products of cross linked fibrin, are a valuable diagnostic test for the exclusion of deep venous thrombosis. D-dimer levels were analyzed in fifty patients suspected of deep vein thrombosis clinically and compared the results with color Doppler ultrasonography. A value of 250 ng mL-1 was chosen as cut off. For the purposes of analysis, results were expressed as either negative (<250 ng mL-1) or positive (≥250 ng mL-1). Patients were classified as low, moderate or high pretest probability for DVT as per Well ’s scoring system. D-dimer assay had a sensitivity of 97.3% (CI 85.8-99.9%), a specificity of 38.5% (CI 13.9-68.4%), a positive predictive value of 81.8% (CI 67.3-91.8%) and a negative predictive value of 83.3% (CI 35.9-99.6%). In patients with a low or moderate pretest probability of DVT, the negative predictive value of this assay was 100% and this test can safely exclude the DVT in these patients. Thus in patients having low and moderate pretest probability automated latex D-dimer test can safely exclude DVT.
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