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Articles by M.G. Matsabisa
Total Records ( 2 ) for M.G. Matsabisa
  O. Da , M. Traore/ Coulibaly , R.S. Yerbanga , B. Koama , N. Ouedraogo , S. Tamboura , Z.P. Dakuyo , M.P. Sekhoacha , J.B. Nikiema , G.A. Ouedraogo , M.G. Matsabisa and J.B. Ouedraogo
  Saye is an antimalarial recipe containing Cochlospermum planchonii Hook. F. (Cochlospermaceae), Phyllanthus amarus Schumach and Thonn (Euphorbiaceae) and Cassia alata L. (Fabaceae). This study assessed the antiplasmodial and antioxidant activity of the aqueous extracts of the individual plants and their combinations. Extracts were assessed on Plasmodium berghei infected mice according to the 4 day suppressive test, for their total phenol contents according to Folin-Ciocalteu method and their antioxidant potential by FRAP assay and by the inhibition of ion induced lipid peroxidation in rat liver homogenate. Macerated extracts from Cochlospermum planchonii, Phyllantus amarus and Cassia alata gave 50.6, 46.3 and 44.9% inhibition of the parasites at 100 mg kg-1 body weight (b.wt.), respectively. At 250 mg kg-1 b.wt. the decocted extract of Cochlospermum planchoii gave 54% inhibition. Decocted extracts of the combinations Cassia alata+Phyllanthus amarus (2:1) and Phyllanthus amarus+Cochlospermum planchonii (2:1) reduced mice parasitemia by about 20-30% at 100 mg kg-1 b.wt. At the same dose, a 4.9-15.9% inhibition was observed with the decocted extract of Cassia alata+Cochlospermum planchonii (1:1) and the whole “Saye” but a higher effect of 43.7 to 50.3% was observed at 250 mg kg-1 b.wt. Phyllantus amarus extract exhibited the highest total phenol content (294 μg TAEs/mg). The highest content in flavonoids 43 μg QE/mg and the highest inhibition of lipid peroxidation (22.56%) were found for Cassia alata+Phyllanthus amarus (2:1) and the best reducing power (41.38 μmol TE/mg) for Saye. Saye appears as promising antioxidant and could be used as preventive agent in oxidative stress diseases such as malaria.
  O. Da , R.S. Yerbanga , M. Traore/Coulibaly , B.K. Koama , Z. Kabre , S. Tamboura , Z.P. Dakuyo , M.P. Sekhoacha , M.G. Matsabisa , J.B. Nikiema , J.B. Ouedraogo and G.A. Ouedraogo
  Objective: Cassia alata L. (Fabaceae), one of the three plants contained in Saye, a polyherbal antimalarial remedy was assessed for its antimalarial potential and safety in mice. Methodology: Organic extracts were prepared from the leaves and tested on the D10 chloroquine-sensitive strain of Plasmodium falciparum using the parasite lactate dehydrogenase assay. The 4 days suppressive test using Plasmodium berghei in mice was used to evaluate the in vivo antiplasmodial activity of the extracts. Animals were treated by oral route, once a day with 50, 100, 250 and 400 mg kg–1 b.wt., of the extracts. The acute toxicity of the extracts was assessed in mice according to Thompson and Weil method. The lethal effects of the extracts on animal’s body weight, tissues, biochemical and haematological parameters were determined at 823.5, 1235.5, 1853 and 2779.5 mg kg–1 b.wt., respectively. Results: The dichloromethane/methane (1:1, v/v) extract of Cassia alata was the most active against Plasmodium falciparum. The mean percent suppression of parasitemia in mice was equal to 22.5, 41.8 and 45.2% at 50, 250 and 400 mg kg–1 b.wt., respectively. No death and no clinically significant changes were recorded in mice. The maximum non-lethal dose was more than 16875 mg kg–1 in animals. No significant changes were observed in body weight, tissues morphology, biochemical and hematological parameters at doses above or equal to 2779.5 mg kg–1 b.wt. Conclusion: The dichloromethane/methanol leaf extract of Cassia alata had a good to moderate in vitro and in vivo antiplasmodial activity and was found to have low toxicity at high doses in tested animals.
 
 
 
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