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Articles by M.G. Magaji
Total Records ( 4 ) for M.G. Magaji
  R.A. Magaji , M.I.A. Saleh , M.G. Magaji and I. Buhari
  The seeds of Mucuna pruriens commonly called Velvet or Mucuna beans have extensively been used in Brazilian and Indian traditional Ayurvedic medicine for many ailments. Exploratory behaviors are affected by drugs based on the types of neurotransmitter they interact with in the brain. Diazepam-induced sleep test in four groups of 6 mice treated with intraperitoneal distilled water (10 mL kg-1), 600, 300 and 150 mg kg-1; hole board test for exploratory behavior in 5 groups of mice treated with intraperitoneal distilled water (10 mL kg-1), diazepam (1.5 mg kg-1), 600, 300 and 150 mg kg-1 of Mucuna pruriens aqueous seed extract respectively were carried out. The studies showed that Mucuna pruriens significantly and dose-dependently prolonged the duration of diazepam-induced sleep which suggests that it possess sleep inducing property. The ability of the extract to significantly reduce the number of head dips in the hole-board test corroborates the CNS depressant potential of the plant extract. It is concluded that Mucuna pruriens may be a remedy in some CNS disorders.
  A.M. Musa , A.H. Yaro , H. Usman , M.G. Magaji and M. Habu
  The phytochemical constituents and some neuropharmacological activity of the methanolic leaf extract of Cissus cornifolia (Bak.) Planch [Family: Vitaceae] was evaluated in mice employing various models. The preliminary qualitative phytochemical analysis carried out on the methanolic leaf extract of Cissus cornifolia revealed the presence of alkaloids, flavonoids, saponins, steroids/terpenoids, stilbenoids and tannins. The neuropharmacological effects of the methanolic leaf extract of Cissus cornifolia on CNS were evaluated using diazepam sleeping time, exploratory behaviour (head dip tests), motor coordination and acute toxicity studies in mice. The extract at tested doses (10, 20 40 mg kg-1 body weight i.p.) produced reduction in exploratory behaviour (head dip test), beam walking assay (foot slips) and potentiate the diazepam-induced sleep in mice; the LD50 was found to be 775.0 mg kg-1 body weight i.p. in mice. These results corroborates with the traditional usage of this plant as a remedy against mental derangement as confirmed by the sedative activity expressed by the extract.
  Y.M. Sani , A.M. Musa , A.H. Yaro , M.B. Sani , A. Amoley and M.G. Magaji
  Cissus polyantha is used in African traditional medicine is the management of pain and inflammatory conditions. This study was therefore designed to evaluate the analgesic and anti-inflammatory activities of the methanol extract of the leaf of Cissus polyantha, as well as to establish the class of phytochemical constituents present in the extract. The analgesic effect was studied using acetic acid-induced writhing and hot plate tests in mice, while anti-inflammatory effect was investigated using carrageenan-induced hind paw oedema in rats. The results of the study showed that the extract significantly (50, 100, 200 mg kg-1) (p<0.001) and dose-dependently inhibited acetic acid-induced writhing. The extract at dose of 100 mg kg-1 increased the mean pain responses by 69.25% compared to control. At the end of third hour after carrageenan administration, the various doses of the extract offered 65.67, 70.15 and 67.16% inhibition of hind paw oedema, respectively. These effects were more remarkable than those produced by ketoprofen (63.8%). Preliminary phytochemical screening revealed the presence of steroids, flavonoids, saponins, tannins and anthraquinones. The intraperitoneal mean lethal dose (LD50) of the extract in mice was estimated to be 774.6 mg kg-1. The findings of this study showed that the methanol leaf extract of Cissus polyantha contains some pharmacologically active principle(s) with analgesic and anti-inflammatory activities and lend credence of the ethnomedical use of the plant in the management of pain and inflammatory conditions.
  M.G. Magaji , Y. Yakubu , R.A. Magaji , A.M. Musa , A.H. Yaro and I.M. Hussaini
  Schizophrenia is a highly disabling chronic psychiatric illness. The existing antipsychotic agents are associated with untoward effects and drug interactions leading to the intensification of search for newer agents with better efficacy and safety profile. Securinega virosa is a commonly used medicinal plant in African traditional medicine. The decoction of the leaves of the plant in combination with other plants is used in the management of mental illness. In this study, we evaluate the antipsychotic potential of the methanol leaf extract (25, 50 and 100 mg kg-1) of the plant using apomorphine-induced stereotypic climbing behavior and swim-induced grooming tests, all in mice. The CNS depressant effect was also evaluated using ketamine-induced sleep test mice. The extract at the highest dose tested (100 mg kg-1) significantly reduced the apomorphine (1 mg kg-1)-induced stereotypic climbing behavior after 30 min. Similarly, haloperidol (2 mg kg-1), the standard agent significantly (p<0.001) decreased the mean climbing behavior. In the swim-induced grooming test, the extract significantly (p<0.01) and dose-dependently decreased the total grooming time. Similarly, haloperidol (2 mg kg-1) significantly (p<0.001) decreased the mean grooming activity. The extract significantly increased the total ketamine-induced sleep duration at doses of 50 and 100 mg kg-1. These findings suggest that the extract possesses antipsychotic and sedative potentials and lend credence to the ethnomedical use of the leaves of the plant in the management of mental illness.
 
 
 
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