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Articles by M.G. Abukakar
Total Records ( 3 ) for M.G. Abukakar
  A.N. Ukwuani , M.G. Abukakar , R.A. Shehu and L.G. Hassan
  The pulp extract of Tamarindus indica is used by traditional herbalists as a purgative, drug vehicle and antiobesity agent. The effect of 28 days administration of Tamarindus indica pulp extract on the body weight and lipid profile of the rat was evaluated. There was a significant increase in the weight of the control compared to the treated which significantly decreased (p<0.05) especially the rats given higher doses (2700 to 4500 mg kg-1 body weight). Serum cholesterol and Low Density Lipoprotein (LDL) revealed a significant decrease (p<0.05) while High Density Lipoprotein (HDL) and triglycerides increased in the controlled group compared to the control. Xenical treated group was not significantly different (p<0.05) from the control. Triglycerides significantly increased (p<0.05) and LDL significantly decreased (p<0.05) in the pulp extract treated group as compared to xenical treated group.
  M.G. Abukakar , A.N. Ukwuani and R.A. Shehu
  The phytochemical analysis and antibacterial activity of aqueous pulp extract of Tamarindus indica were studied. The aqueous pulp extract of this plant was obtained using hot water extraction method. The antibacterial activity of aqueous pulp extract of this plantwas carried out against four bacteria; Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi by disc diffusion method. Phytochemical constituents present in the extract were found to include saponins (2.2%), alkaloids (4.32%) and glycosides (1.59%). Aqueous pulp extract of Tamarindus indica showed antibacterial activity against all the tested bacteria in the order of sensitivity as Staphylococcus aureus>Escherichia coli>Pseudomonas aeruginosa with the exception salmonella typhi. The antibacterial activity of aqueous pulp extract on Staphylococcus aureus was sensitive at 80, 120, 140, 160 and 180 mg mL-1 of extract with 0.2, 0.3, 0.6, 0.8 and 10.0 mm zones of inhibition while Escherichia coli revealed 0.2, 0.2, 0.4 and 0.6 mm zones of inhibition at 120, 140, 160 and 180 mg mL-1 of extract, respectively. Pseudomonas aeruginosa was only sensitive at 140, 160 and 180 mg mL-1 of the extract with 0.4, 0.6 and 0.8 mm zones of inhibition.
  M.G. Abukakar , A.N. Ukwuani and R.A. Shehu
  The effects of graded doses of Tamarindus indica pulp extract on the haematological, toxicological and histopathological indices in rats were evaluated. Hematological parameter was determined using micro-hematocrit method and Neubauer hemocytometer counting chamber. The haematological parameters (PCV, WBC, Lymphocytes and Monocytes) of the treated groups showed no significant difference (p< 0.05) when compared with the control. Although there was a significant increase (p< 0.05) (p< 0.01) in the nuetrophils in group 3 and 4 and decrease (p< 0.05) (p< 0.01) in eosinophils at group 4 and 5, respectively. There was no fatality recorded in the acute toxicity tests when the animals received 900-4500 mg kg-1 body weight of the extract, however the higher doses of the extract (2700-4500 mg kg-1 body weight) exhibited some behavioral changes in the rats such as aggressive scratching of the body and mouth part, anorexia, mild restlessness and sensitive to slight sound. There was no significant difference (p< 0.05) in the toxicological parameters investigated when compared with the control. The gastro intestinal tract revealed no apparent congestion or hemorrhage while the histopathological examination of liver and kidney showed no visible lesions indicating its non toxic effect to these organs. These results have provided scientific evidence to justify the safety of this plant in tradition medicine.
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