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Articles by M.F.M.C. Coura
Total Records ( 2 ) for M.F.M.C. Coura
  G.F. Dire , M.C.L. Almeida , M.F.M.C. Coura , S.D.D. Vasconcelos , P.R.A. Siqueira , R.M. Duarte , J.S. Rodrigues , J.C.S. Oliveira , M.L. Fernandes and M. Bernardo-Filho
  The use of natural products as medicines has been growing in the entire world. There are concerns that these products may contain potentially toxic ingredients and contaminants such as heavy metals. The labeling of blood constituents with technetium-99m has been influenced by the presence of natural extracts. We evaluated the influence of a chayotte (Sechium edule) extract (100%v/v macerated) on the labeling of blood elements with 99mTc. The animals were treated with the extract during 15 days. Samples of blood were carried out with specific blood biochemistry kits. The present study analyzed the influence of chayotte in the survival of the strain of Escherichia coli AB1157 submitted to reactive oxygen species induced by stannous chloride. There was a reduction of the lethal effect induced by stannous chloride on the survival of the E. coli culture in the presence of chayotte. The results indicated a decrease in the level of glucose and globulin The effect of the extract could be explained by its metabolic transformation inducing the generation of oxidant metabolites. The culture of bacteria when was treated with stannous chloride and chayotte simultaneously, the extract could be reacting with stannous chloride ions, protecting them against the oxidation avoiding the generation of reactive oxygen species.
  G.F. Dire , M.F.M.C. Coura , M.C.L. Almeida , S.D.D. Vasconcelos , P.R.A. Siqueira , R.M. Duarte , J.S. Rodrigues , J.C.S. Oliveira , M.L. Fernandes and M. Bernardo-Filho
  Stannous chloride (SnCl2) is employed as a reducing agent to obtain Technetium-99m-labelled radiopharmaceuticals in nuclear medicine kits, being inject endogenously in humans. Toxic effects of. these kits were not studied, thus making it important to evaluate their impact in humans. The use of natural extracts as medicines is growing around the world. The chayotte (Sechium edule) is a subtropical vegetable with potent diuretic action. It is used in folk medicine due its hypotensor effect. In this study, plasmid deoxyribonucleic acid (DNA) was exposed to chayotte extracts (macerated) (0.1g mL-1) in presence of stannous chloride (SnCl2). Samples of the plasmid DNA were analyzed through agarose gel electrophoresis. The results show that the chayotte extract was capable of damaging the DNA in the presence and in the absent of SnCl2.
 
 
 
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