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Articles by M.E.H. Mazumder
Total Records ( 2 ) for M.E.H. Mazumder
  S.M. Raquibul Hasan , M.M. Hossain , R. Akter , M. Jamila , M.E.H. Mazumder , M.A. Alam , A. Faruque , S. Rana and S. Rahman
  Analgesic potential of the pet ether (PECB), chloroform (CCB), n-butanol (NBCB) and hydromethanolic (HMCB) fractions of the aerial parts of Commelina benghalensis Linn. was evaluated for centrally acting analgesic property using hotplate and tail immersion method and peripheral pharmacological actions using acetic acid-induced writhing test to scientifically validate some of the folkloric and ethnomedical uses of the plant. All fractions, at the dose of 200 and 400 mg kg-1 b.wt., displayed significant analgesic action in a dose dependent manner in the tested models. In acetic acid-induced writhing test, all extracts exhibited significant (p<0.05) reduction of writhing response in a dose dependent manner; the response decreased in the order Diclofenac-Na (76.16%) > CCB2 (68.8%) > NBCB2 (61.9%) > HMCB2 (52.8%) > PECB2 (48.0%). In hotplate and tail immersion method, all fractions caused a significant (p<0.0-0.001) increase in latency time and the results are comparable to the standard drug Nalbuphine. These results suggest significant analgesic potential of C. benghalensis and thereby justify its traditional uses in various types of pain.
  M.S. Hossain , M.B. Alam , N.S. Chowdhury , M. Asadujjaman , R. Zahan , M.M. Islam , M.E.H. Mazumder , M.E. Haque and A. Islam
  The present study was designed to investigate the antioxidant, analgesic and anti-inflammatory potential of the methanolic extract along with its organic soluble fractions of the herb Eclipta prostrata. In addition, total phenolic and flavonoid content and total antioxidant capacity were also determined. Antioxidant potential of the extract/fractions was evaluated by DPPH (1,1diphenyl-2-picrylhydrazyl), NO (nitric oxide) and ONOO¯ (peroxynitrite) scavenging assay method. Ethyl acetate fractions (EtOAc) showed highest scavenging activity in all the methods with IC50 value of 12.98±0.08, 45.98±0.07 and 14.45±0.18 μg mL-1 for DPPH, NO and ONOO- assay method, respectively. In reducing power assay, EtOAc fraction also showed significant (p<0.001) activity. Further, the extract/fractions were studied for their analgesic (hot plate, tail immersion and acetic acid induced writhing test) and anti-inflammatory (carrageenan induced paw edema in rats) activities at a dose level of 200 and 400 mg kg-1 body weight. Among all the extract/fractions, EtOAc fraction showed a dose dependent and significant (p<0.005, p<0.05) analgesic activity in all the tested method. EtOAc fractions also reduced the paw edema considerably (86.80% inhibition after 3 h, p<0.005, p<0.05) in dose dependent manner compared to carrageenan induced rat. Altogether, these results suggest that the MeOH extract and its organic soluble fractions could be used as a potential antioxidant, analgesic and anti-inflammatory agent.
 
 
 
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