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| Articles
by
M.B. Tijjani |
Total Records (
3 ) for
M.B. Tijjani |
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K.A. Sanda
,
U.K. Sandabe
,
F.A. Sanda
,
M.B. Tijjani
,
Y.B. Majama
and
B.G. Gambo
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Phytochemical screening of aqueous root extract of Leptadenia hastata
was investigated in Maiduguri northern Nigeria, to evaluate the active component
of the plant. Soxhlet extraction method was used to determine the phytochemical
component of the extract. Saponins and flavonoids had high scores in the extract,
alkaloids and pentoses had moderate scores, while tannins and ketones had low
scores. Combined anthraquinones, free anthraquinones, reducing sugar, carbohydrates,
glycosides and monosaccharides were not detected in the extract. In conclusion,
Leptadenia hastata aqueous root extract contains pharmacologically active
components which support its Ethno-botanical claims of traditional herbalist
in Northern Nigeria in the treatment of various ailments. |
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M.B. Tijjani
,
A.A. Barkindo
,
S. I. Ngulde
,
B. Wampana
and
K.A. Sanda
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Decoction of Detarium microcarpum, used by traditional herbalist as antidiarrheal agents, was investigated for its efficacy. Determination of phytochemical constituents of the aqueous extract was carried qualitatively using standard laboratory procedures. Experimentally-induced diarrhoea and intraluminal pooling and charcoal transit time using castor oil was used as a model for assessing antidiarrheal efficacy of the plant. The result showed that the plant contain alkaloid, tannins, flavonoids and carbohydrates. The extract gave a protection against castor oil induced diarrhoea of 53% compared with standard drug loperamide that gave 91% protection. Intraluminal fluid volume was significantly (p≤0.05) decreased compared negative control. Distance travelled by charcoal meal was found to be significantly (p≤0.05) lower than the negative control and is comparable to with the positive control group that received atropine. The results of this study suggest that the plant was found to possess antidiarrheal effect as claimed by herbalist. |
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M.B. Tijjani
,
I.A. Bello
,
A.B. Aliyu
,
T. Olurishe
,
S.M. Maidawa
,
J.D. Habila
and
E.O. Balogun
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Methanol extract of the root of Cochlospermum tinctorium
was evaluated for antibacterial activities using hole-in-plate bioassay
technique against Escherichia coli, Staphylococcus aureus,
Klebsiella pneumoniae, Corynbacterium ulcerans, Proteus
mirabilis and Shigella dysentriae using ciprofloxacin (10 μg
mL-1) and gentamicin (10 μg mL-1) as reference
standards. The extract was active on all the test organisms at concentration
of 2000 μg mL-1. The activity of the extract against S.
dysentriae was found to be more potent with MIC 100 and MBC 500 μg
mL-1. Time kill studies showed that the antibacterial activities
were time dependent. Phytochemical screening revealed the presence of
alkaloids, flavonoids, tannins and cardiac glycosides. These phytochemicals
could be responsible for the antimicrobial activities exhibited by the
extract and hence justify the ethnomedicinal uses of C. tinctorium. |
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