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Articles by M.B. Tijjani
Total Records ( 3 ) for M.B. Tijjani
  K.A. Sanda , U.K. Sandabe , F.A. Sanda , M.B. Tijjani , Y.B. Majama and B.G. Gambo
  Phytochemical screening of aqueous root extract of Leptadenia hastata was investigated in Maiduguri northern Nigeria, to evaluate the active component of the plant. Soxhlet extraction method was used to determine the phytochemical component of the extract. Saponins and flavonoids had high scores in the extract, alkaloids and pentoses had moderate scores, while tannins and ketones had low scores. Combined anthraquinones, free anthraquinones, reducing sugar, carbohydrates, glycosides and monosaccharides were not detected in the extract. In conclusion, Leptadenia hastata aqueous root extract contains pharmacologically active components which support its Ethno-botanical claims of traditional herbalist in Northern Nigeria in the treatment of various ailments.
  M.B. Tijjani , A.A. Barkindo , S. I. Ngulde , B. Wampana and K.A. Sanda
  Decoction of Detarium microcarpum, used by traditional herbalist as antidiarrheal agents, was investigated for its efficacy. Determination of phytochemical constituents of the aqueous extract was carried qualitatively using standard laboratory procedures. Experimentally-induced diarrhoea and intraluminal pooling and charcoal transit time using castor oil was used as a model for assessing antidiarrheal efficacy of the plant. The result showed that the plant contain alkaloid, tannins, flavonoids and carbohydrates. The extract gave a protection against castor oil induced diarrhoea of 53% compared with standard drug loperamide that gave 91% protection. Intraluminal fluid volume was significantly (p≤0.05) decreased compared negative control. Distance travelled by charcoal meal was found to be significantly (p≤0.05) lower than the negative control and is comparable to with the positive control group that received atropine. The results of this study suggest that the plant was found to possess antidiarrheal effect as claimed by herbalist.
  M.B. Tijjani , I.A. Bello , A.B. Aliyu , T. Olurishe , S.M. Maidawa , J.D. Habila and E.O. Balogun
  Methanol extract of the root of Cochlospermum tinctorium was evaluated for antibacterial activities using hole-in-plate bioassay technique against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Corynbacterium ulcerans, Proteus mirabilis and Shigella dysentriae using ciprofloxacin (10 μg mL-1) and gentamicin (10 μg mL-1) as reference standards. The extract was active on all the test organisms at concentration of 2000 μg mL-1. The activity of the extract against S. dysentriae was found to be more potent with MIC 100 and MBC 500 μg mL-1. Time kill studies showed that the antibacterial activities were time dependent. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins and cardiac glycosides. These phytochemicals could be responsible for the antimicrobial activities exhibited by the extract and hence justify the ethnomedicinal uses of C. tinctorium.
 
 
 
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