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Articles by M.A. Rajion
Total Records ( 3 ) for M.A. Rajion
  A.L. Tan , M. Ebrahimi , T. Hajjar , S. Vidyadaran , A.Q. Sazili , M.A. Rajion and Y.M. Goh
  This study was conducted to investigate the effects of modifying the n-6:n-3 Fatty Acid Ratio (FAR) of diets using fish oil, soybean oil and butter on growth performance and the fatty acid profile of rat fed with commercial concentrate diet. Fifty individually housed Sprague-Dawley rats (average of 130±2 g of body weight) were fed concentrates at 5% of body weight daily. The treatments consisted of dietary n-6:n-3 FAR of 1.94:1, 5.67:1, 51.82:1 and 61.69:1. After feeding for 20 weeks in individual cages, rats were sacrificed 15 h after feeding and samples of blood were collected. Increasing dietary saturated fatty acid increased the body weight significantly in compared to other treatment groups. Concentrations of n-6:n-3 FAR in plasma increased linearly (p<0.05) with increasing dietary n-6:n-3 FAR. Concentrations of C18:3 n-3 decreased (p<0.001) in the diet with high level of soybean oil whereas that of C18:2n-6 did not change in all treatment groups (p>0.05) in rat plasma with different n-6:n-3 FAR. Proportions of oleic acid in plasma were unchanged by diet. The proportion of Arachidonic Acid (AA) decreased (p<0.05) in plasma of rat that fed with low level of n-6:n-3 FAR in compare to the diet with higher level. Proportions of all measured long chain n-3 fatty acids were greater in plasma when diets contained more C22:5 n-3 and 22:6 n-3 from fish oil. By decreasing the dietary n-6:n-3 FAR, the proportions of long chain n-3 fatty acids in plasma increased dramatically; specifically, 22:6 n-3 and 22:5 n-3.
  M. Ebrahimi , M.A. Rajion , Y.M. Goh , A.Q. Sazili , A.F. Soleimani and J.T. Schonewille
  Twenty four goats were allocated to three groups (n = 8) and fed either a control diet Without Oil Palm Fronds (CON), a diet incorporated with 25% Oil Palm Fronds (OPFM) or 50% Oil Palm Fronds (OPFH) for 100 days to evaluate their growth rates, carcass characteristics and subcutaneous fatty acid profiles. Animals in all three groups exhibited similar final body weights (p>0.05). The OPFH group showed a significant linear reduction (p<0.05) in dressing percentage, warm carcass weight and back fat thickness and total muscle when compared to the CON group. The total n-3 Polyunsaturated Fatty Acid (PUFA) concentrations in the subcutaneous fat of the OPFH animals were significantly higher (linear, p<0.05) than the CON group. The diet containing 25% of oil palm fronds did not produce any adverse effects on the growth performance and carcass characteristics. This demonstrates an environmental-friendly way of utilizing agricultural waste by products for the small ruminant industry in tropical countries growing oil palm tree.
  A.W. Tekeleselassie , M.A. Rajion , Y.M. Goh , M. Moteshakeri , A.F Soleimani and M. Ebrahimi
  Insulin resistance is a growing worldwide syndrome that predispose human to a number of chronic diseases such as diabetes and cardiovascular diseases. Various studies have indicated that insulin action is highly influenced by diet compositions particularly dietary fat intake and proportion of n-3 and n-6 Polyunsaturated Fatty Acids (PUFA). The current study was designed to assess the influence of High Fat Diet (HFD) with different n-6: n-3 Fatty Acid Ratios (FAR) on insulin sensitivity, plasma triacylglycerol (TAG) and lipoprotein profile. Forty male Sprague-Dawley rats were randomly allocated into four groups and received the isocaloric high fat diets enriched with either high n-6: n-3 fatty acid ratio (HFAR), medium n-6: n-3 fatty acid ratio (MFAR), low n-6: n-3 fatty acid ratio (LFAR) and compared with control rats fed standard chow (CTRL). The plasma insulin level of HFAR fed rats manifested significantly (P<0.05) higher concentration in most of the time points compared to the other groups. The corresponding insulin AUC (ng/L/120min) and insulin sensitivity index of HFAR fed rats appeared to be significantly higher (P<0.05) than CTRL (335.5±38.5), LFAR (273.7±37.6) and MFAR (265.9±21.7) groups. Blood lipid profile were found to be healthier in the LFAR and MFAR supplemented groups with significantly (P<0.05) lower total cholesterol and TAG levels. This study showed the possible protective effect against insulin resistance when low n-6: n-3 fatty acid ratio in high fat diets are applied in a rat model.
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