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Articles by M.A. Kirmani
Total Records ( 2 ) for M.A. Kirmani
  M.R. Fazili and M.A. Kirmani
  In Kashmir, equine species plays a very important role in the socio-economic life of the human population. They are the beasts of burden and have also been playing important role in tourism promotion. The majority of the equine population comprises of ponies that are owned only by socially and economically deprived landless, marginal and small farmers. Unfortunately, till date the contribution of this species has neither been calculated nor recognized, their welfare often neglected. No attention has been paid to research and development of this domestic animal. In this study, the current status of equines in Kashmir, the constraints affecting their development and survival, priority research areas and establishment of species specific infrastructure is highlighted.
  T.A. Bhat , M.R. Mir , I. Qasim , S.S. Misra and M.A. Kirmani
  5, 10-Methylenetetrahydrofolate Reductase (MTHFR) is one of the key enzyme in the metabolism of homocysteine, where it catalyses its remethylation. The autosomal recessive bp C677T mutation in the MTHFR gene leads to the substitution of valine for alanine. Individuals who are homozygous for this C677T mutation exhibit a decreased specific activity and increased thermolability of MTHFR. This leads to increased plasma levels of homocysteine, which is a known risk factor for atherosclerosis and related disease. This study was conducted to find out the distribution and frequency of C677T mutation in the general Kashmiri population by employing PCR-RFLP method for C677T mutation analysis. A group of 110 volunteers (75 males and 35 females) has been analyzed for the MTHFR polymorphism, which revealed the following distribution, 62% individuals were without mutation (C/C), 33% were heterozygous (C/T) and 5% homozygous (T/T).
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