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| Articles
by
M.A. Al-Rehany |
Total Records (
1 ) for
M.A. Al-Rehany |
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N.M. Abdel-Hamid
,
L.M. Faddah
,
M.A. Al-Rehany
and
A.A. Awad
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Erectile Dysfunction (ED) is a prevalent problem among most of diabetic
patients. This defect is extensively treated by Sildenafil Citrate (SC),
which is a potent phosphodiesterase -5 inhibitor (PDE-5 I). The mechanism
of SC in treating ED in an experimental diabetic model, in conjunction
with a potent antioxidant, vitamin E (vit E) is to be elucidated. Here,
we report that, whether alone or in combination with E, SC induces penile
erection, mostly, through organized modulation of blood neurotransmitters,
namely, Serotonin (Ser), Dopamine (Dop), Nor-Epinephrine (NEP) and Nitric
Oxide (NO), in addition to potassium (K), controlled calcium (Ca) influx
modulation, affecting neurotransmitters release into the circulation,
without apparent impact on sodium level (Na). In the present study, Ser,
Dop, NEP and NO blood levels were together, significantly up-regulated
in normo-glycemic and more significantly in alloxan diabetic rats by SC
treatment, an effect which was non-significantly prohibited by E combination.
K level was elevated by SC in normo-glycemic, but decreased in diabetic
rats. This later action was reversed by E, however, Na level was only
significantly elevated in diabetic group, given SC combined with E, but
Ca levels were non-significantly changed. These actions of SC elucidate-in
part-the mechanism of its action and necessitate care to its impact on
diseases related to autonomic neurotransmission. |
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