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Articles by M.A. Akanji
Total Records ( 6 ) for M.A. Akanji
  O.S. Adeyemi , M.A. Akanji , T.O. Johnson and J.T. Ekanem
  Iron is essential for living cells, including pathogenic microorganisms. So altered iron availability is often a key component in the host-pathogens interplay. Secondary to infection with pathogens, there is the activation of macrophages. Activated macrophages by action of inducible Nitric Oxide Synthase (iNOS) produce Nitric Oxide (NO) as part of host defense mechanism. However, production of nitric oxide as obtained in Trypanosoma brucei infection strongly correlates with increased cellular iron. The expanded free iron pool may become available to invading parasites and thus promotes proliferation. Establishing the link between these two important molecules may offer new treatment strategies for African trypanosomosis in the face of increasing toxicity and parasite resistance to drugs currently available for treatment of African trypanosomosis.
  O.S. Adeyemi , M.A. Akanji and J.T. Ekanem
  Previous report from our laboratory demonstrated the activity of ethanolic extract of Psidium guajava leaf against bloodstream forms of trypanosomes in an experimental infection. The present study investigated the mitigating effects of P. guajava leaf extract on Trypanosoma brucei brucei-induced changes in rat serum and tissue total protein, albumin, globulin, unconjugated bilirubin and total bilirubin. Our data revealed that trypanosome infection caused a rise in protein and globulin concentrations but reduced albumin concentrations were observed (p<0.05). There was also a significant increase in the serum and tissue bilirubin concentrations of the infected animals. In contrast, however, these biochemical alteration were less severe (p<0.05) in the treated group relative to the untreated counterparts. The data suggest the capacity of the ethanolic extract of P. guajava in downplaying the severity of the conditions usually associated with trypanosome infections.
  M.A. Akanji , M.T. Yakubu and M.I. Kazeem
  The aim of this study was to investigate the hypolipidemic potential of aqueous extract of Rauvolfia vomitoria root and assess its toxicological effect in selected tissues of rats. Aqueous extract of Rauvolfia vomitoria root was administered to wistar rats daily at 24 h interval at a dosage of 200 mg kg-1 b.wt. following which the rats were sacrificed after receiving 1, 3, 5, 10, 20 and 30 daily oral doses. Administration of the extract produced significant reduction (p<0.05) in the concentration of the Low-density Lipoprotein Cholesterol (LDL-C), triglyceride and atherogenic indices while a dose-dependent significant increase (p<0.05) occurred in the High-density Lipoprotein Cholesterol (HDL-C) concentration. Significant changes were also observed (p<0.05) in the activities of alkaline phosphatase (ALP) and acid phosphatase (ACP) in all the tissues studied except small intestine. There were significant fluctuations (p<0.05) in the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the tissues except in the kidney. The results suggest that aqueous extract of Rauvolfia vomitoria root possesses hypolipidemic potential but caused alterations in the concentration of the enzymes studied and so may not be completely safe at the dose used in this study.
  F.A. Sulaiman , M.A. Akanji , H.O.B. Oloyede , A.A. Sulaiman , A. Olatunde , E.B. Joel , T.H. Adewale , H.A. Adeboye , S.O. Idris , A.L. Quadri , R.A. Oyegoke and O.S. Adeyemi
  Study investigated the effect of oral administration of gold-silver nanoparticles on rat biochemical parameters and tissue morphology. Wistar rats weighing approximately 180±7 g were randomly assigned into four groups. Animals in the control group received distilled water once daily for 30 days while, those in the treatment groups were administered 10, 50 and 100 mg kg–1 b.wt. gold-silver nanoparticles. The rats were sacrificed under slight anesthesia, 24 h after the last treatments. Blood and vital organs including the heart, kidney and liver were collected and prepared for biochemical and histopathological determinations. Exposure to Ag/Au nanoparticles altered the rat serum lipid profile; lowering the HDL-C while raising the atherogenic index. Exposure of Ag/Au nanoparticles in rats caused significant alteration to the levels of serum albumin, total protein, bilirubin, urea and creatinine. The activities of alanine transaminase, aspartate transaminase and alkaline phosphatase in rat serum and tissues were also significantly altered by Ag/Au nanoparticles exposure. The histopathological examination revealed inflammation and cellular degeneration caused by exposure to the Ag/Au nanoparticles. We show evidence that Ag/Au nanoparticles elevated atherogenic index, as well as caused biochemical and morphological alterations, reminiscent of cellular injury.
  S.O. Kolawole , O.T. Kolawole and M.A. Akanji
  In this study, the effects of aqueous extract of Khaya senegalensis stem bark on hematological and biochemical parameters were investigated in rats. The rats were randomly divided into four groups of 5 rats per group. Group I (control) received normal saline while Groups II, III and IV were fed 50, 100 and 200 mg kg-1 of Khaya senegalensis stem bark extract orally for 21 days. Repeated administration of the extract resulted in a dose-dependent increase in total protein, globulin, urea and creatinine. The extract also produced an increase in the plasma levels of some liver enzymes namely Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline Phosphatase (ALP). These changes were significant (p<0.05) with 100 and 200 mg kg-1 of the extract. At this same dose range, the extract caused a significant decrease in Red Blood Cells (RBC), Packed Cell Volume (PCV) and Hemoglobin level (Hb). In contrast, serum sodium ion (Na+) and potassium (K+) ion concentrations were elevated following the administration of the extract but there were no significant changes in the serum chloride (Cl¯) and bicarbonate ions (HCO3¯) concentrations. The results of this study suggest that prolonged use of aqueous extract of Khaya senegalensis stem bark extract may adversely affect vital organs in the body.
  O.S. Adeyemi , M.A. Akanji and J.T. Ekanem
  Anaemia has been shown to be a cardinal feature in African trypanosomosis. This study evaluated the effects of the ethanolic extract of Psidium guajava leaf on some haematological indices in rats experimentally infected with Trypanosoma brucei brucei. Observations revealed significant (p<0.05) decreases in the values for Packed Cell Volume (PCV), Haemoglobin (Hb), Red Blood Cell (RBC) counts, Mean Corpuscular Volume (MCV), Mean Concentration Haemoglobin Count (MCHC) in infected group relative to the treated as well as the uninfected animals. There was a significant (p<0.05) increase in the White Blood Cell (WBC) counts in infected animals when compared with the infected but treated animals. Also significant changes were observed for neutrophil in the infected animals compared to control and infected but treated groups (p<0.05). However, treatment with the ethanolic extract was able to significantly (p<0.05) improve the PCV, Hb, RBC, MCV, MCHC and neutrophil levels relative to the infected but untreated animals. Results demonstrate the anti-anaemic properties of the ethanolic extract of P. guajava in rats infected with T.b. brucei.
 
 
 
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