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by
M.A. Gafur |
Total Records (
4 ) for
M.A. Gafur |
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Zakia Sultana Sathi
,
Md. Aziz Abdur Rahman
and
M.A. Gafur
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A pure antimicrobial compound was isolated from the chloroform extract of the broth culture of Streptomyces species by preparative thin layer chromatography (PTLC) and was characterized as 4-hydroxy nitrobenzene (ZS-3) on the basis of spectral data (UV, IR, 1H-NMR, HMBC and HMQC). The compound showed significant antimicrobial activity against six gram positive bacteria, ten gram negative bacteria and three pathogenic fungi. The minimum inhibitory concentration (MIC) of the compound determined against ten pathogenic organisms was found to be between 32-64 g/ml. |
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Md. Harun-Or-Rashid
,
Nurul Karim
,
M.A. Gafur
,
Md. Golam Sadik
,
A.S.M. Anisuzzaman
,
Noaki Sugimoto
and
A.T.M. Zafrul Azam
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Extensive chromatographic separation and purification of the organic solvent extracts of stem of I. turpethum afforded three compounds, N-p-coumaryl tyramine (EH4), daucosterol (CH1) and 2-hydroxybenzoic acid (CH2); first isolated from this plant. The structures of these compounds were determined by spectroscopic analysis, including 1H- and 13C-NMR, as well as by UV, IR and electrospray ionization mass spectrometry (ESI-MS). On screening against pathogenic bacteria and fungi; compounds CH2 and EH4 as well as extracts showed significant antibacterial and antifungal activity. The Minimum Inhibitory Concentration (MIC) against Bacillus subtilis and Shigella dysenteriae of compounds CH2 and EH4 were 64 μg mL-1. On in vivo cytotoxicity studies against brine shrimp; compounds CH2 and EH4 showed LC50 (Leathal concentration for 50% mortality) values 54.03 and 43.41 μg mL-1, respectively. |
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A.S.M. Anisuzzaman
,
Naoki Sugimoto
,
Golam Sadik
and
M.A. Gafur
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The sub-acute toxicity studies of 5-Hydroxy-2 (Hydroxy-methyl) 4H- pyran-4 one, a metabolite of Aspergillus fumigatus was carried out in rats. The compound was administered at a dose of 300 μg/rat/day for 21 days. The gross general observation such as changes of body weight, hematological profiles, biochemical parameters of blood and the histopathology of the liver, kidney, heart, lung, spleen were investigated both in control and experimental rats. The body weights of the rats were slightly increased. The change of hematological and biochemical parameters were statistically insignificant. No abnormalities were found in the histopathology of the liver, kidney, heart, lung and spleen in the experimental group of rats when compared with control group of rats. |
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Md. Aziz Abdur Rahman
,
M.A. Gafur
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Md. Ekramul Islam
,
Md. Anwar-ul-Islam
and
Md. Aktar Uzzaman Chowdhury
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The subacute toxicity study of a brown antimicrobial metabolite Di (2-ethyl hexyl) Phthalate (AK2), isolated from the culture filtrate of a Streptomyces species, was carried out on long Evan`s rats. The studies include the gross general observations such as changes in body weight, haematological profiles [such as total count of red blood cells (RBC) and white blood cells (WBC), differential count of WBC, platelet count and haemoglobin (Hb) percentage], biochemical parameters of blood such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase, uric acid and creatinine and histopathology of the liver, kidney, heart, lung and spleen of both control and experimental groups of rats. The change of haematological and biochemical parameters were statistically insignificant. No abnormalities were found in the histopathology of the liver, kidney, heart, lung and spleen in the experimental group of rats at a dose of 200 μg/rat/day for 14 consecutive days, when compared with the control group. |
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