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Articles by M.A. Aderogba
Total Records ( 4 ) for M.A. Aderogba
  M.A. Aderogba , E.K. Okoh , T.A. Adelanwa and E.M. Obuotor
  In this study a comparative antioxidant activity of the leaf extracts of P. reticulatum and P. thonningii have been evaluated using the DPPH free radical scavenging assay. The butanol fraction of P. reticulatum exhibited the highest activity (EC50 = 10.27 ± 0.02 μ g mL-1), while crude extract of P. thoninngii had the least activity (EC50 = 50.94 ± 0.27 μ g mL-1). These results suggested strong antioxidant activity potentials of the plants but less than ascorbic acid.
  M.A. Aderogba , E.K. Okoh and T.O. Idowu
  The ethyl acetate extract of Piliostigma reticulatum leaves was investigated for its antioxidant constituents. Isolated secondary metabolites of the leaves extract include: 2-O-(p-hydroxyphenyl)-5-hydroxy-6-C-methyl-7-methoxychromone (piliostigmin) 1, 6-C- methylkaempferol- 3-methyl ether 2, quercetin 3, quercetrin (quercetin-3-O-rhamnose) 4, and Isoquercetrin (quercetin-3-O-glucoside) 5. These compounds were evaluated for their antioxidant potentials. A rapid test for antioxidants using DPPH (1,1-dipheny-2-picryhydrazyl) TLC screening, demonstrated considerable radical scavenging activity for all the compounds. The DPPH spectrophotometric method was employed for quantitative determination of radical scavenging activity. The activity was expressed as EC50 value, which ranges between 4.68±0.03 and 50.76±1.71 for the flavonoids constituent.
  T.O. Idowu , E.O. Iwalewa , M.A. Aderogba , B.A. Akinpelu and A.O. Ogundaini
  Eleagnine, an alkaloid isolated from Chrysophyllum albidum seed cotyledon was investigated to evaluate its potential antinociceptive, anti-inflammatory and antioxidant activities. The antinociceptive effects were carried out using flick, hot-plate tests and acetic-acid induced writhings in mice. The anti-inflammatory activity and the pain threshold were assessed on the oedematous right hind paws of rats using plethysmometer and analgesiometer respectively. The antioxidant effect was carried out in vitro using DPPH (1,1-diphenyl-2-picrylhydrazyl) assay. The compound demonstrated potent analgesic (in all the four models used both peripheral and central sites), anti-inflammatory and a very weak antioxidant properties Naloxone (an opiod antagonist) showed that the analgesic effect was mediated through opiod transmission in both central and peripheral sites while its anti-inflammatory effect involve the inhibition of histamine, 5-HT, prostaglandins in carrageenan induced oedema. Antioxidant activity of the eleagnine ranges between 46.1 and 15.1% for the tested concentrations. This was far less than what observed for ascorbic acid. At much lower concentration. These pharmacological effects of this alkaloidal compound described here may suggest that eleagnine is one of the constituents of Chrysophyllum albidum responsible for the ethnomedical uses as antimicrobial agent through anti-inflammatory property.
  A.O. Adeloye , M.A. Aderogba , T.O. Idowu , E.M. Obuotor and A.O. Ogundaini
  The antioxidant activity of the 50% aqueous ethanol leaf extract and solvent fractions of Alchonea laxiflora were evaluated using DPPH Spectrophotometric assay. The two fractions tested, ethyl acetate andn-butanol fractions exhibited a relatively high activity with EC of 12.97?0.30 ?g mLG and 24.34?0.33?g mLG , 50 respectively. The crude extract, exhibited the least activity (EC 106.74?0.29). All tested samples were however 50, less potent than ascorbic acid used as reference standard (EC 4.78?0.25). Bioassay guided fractionation of 50, the n-butanol fraction using a combination of Accelerated gradient Chromatography (AGC) and Sephadex LH-20 column chromatography led to the isolation of two flavonoids. These compounds were identified as taxifolin glycoside and quercetrin using spectroscopy techniques such as- MS, ?H and ??C NMR.
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