Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by M. Vijayakumar
Total Records ( 2 ) for M. Vijayakumar
  R. Paramaguru , P. Silambu Janaki , M. Bavani Eswaran , Ch.V. Rao , A.K.S. Rawat and M. Vijayakumar
  Background: The high antioxidant activity compounds derived from plants are paramount demand for the pharmaceutical, food industries, mitigating their use as replacements for synthetic antioxidants which are playing significant role in preventing many diseases. This research study was designed to investigate the free radical scavenging and lipid peroxidation inhibition potential of 50% ethanolic extract of leaves of Murraya paniculata (MPET) and its various fractions of hexane (MPHF), chloroform (MPCF), ethyl acetate (MPEF) and methanol (MPMF). Materials and Methods: The free radical-scavenging potential of all fractions of Murraya paniculata extract were determined by β-carotene bleaching assay, 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity, Nitric oxide (NO), Hydroxyl radical (OH) and ferryl bipyridyl complex scavenging activity. Similarly, Lipid Peroxidation inhibition (LPO) using Thiobarbituric Acid Reactive Substances (TBARS) in rat liver homogenate and total antioxidant capacity. In addition to that integral anti oxidative capacity was studied by Photochemiluminescence assay (PCL). Results: In β-carotene bleaching assay, MPEF showed acme percentage of antioxidant activity, MPET showed moderate percentage of antioxidant activity, good radical scavenging activity at various concentrations (200-1000 μg mL-1) against DPPH and the same showed modest scavenging activity against NO, OH, ferryl bipyridal complex and LPO inhibition. Further among the fractions, MPEF showed potent scavenging activity against DPPH, NO, OH, ferryl bipyridal complex and LPO Inhibition. MPMF showed moderate scavenging activity against DPPH, OH, NO Radicals. Conclusion: The 50% ethanolic extract of leaves of Murraya paniculata and its ethyl acetate fraction (MPEF) were very effective antioxidants.
  A. Balasubramaniam , R. Manivannan , R. Paramaguru , Papiya Mitra Mazumder and M. Vijayakumar
  Background: This study was designed to investigate the anti-inflammatory and free radical scavenging potential of 50% ethanolic extract of stem bark of Toddalia asiatica (L.) Lam. Materals and Methods: The anti-inflammatory activity of 100, 200, 400 mg kg-1 of 50% ethanolic extract of stem bark of Toddalia asiatica was assessed by Carrageenan-induced rat paw edema method and Cotton pellet granuloma method. The antioxidant activity of the same was assessed by Free radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), Nitric oxide scavenging activity, Hydroxyl radical scavenging activity and Chelation of Ferrous (Fe2+) ions. Results: All the three doses (100, 200, 400 mg kg-1) of the extract showed reduction in paw volume from first hour to third hour significantly. The extract at a dose of 400 mg kg-1 p.o. of the extract showed the maximum value 44.37% of anti-inflammatory activity. The 100, 200, 400 mg kg-1 p.o. of the extract significantly (p<0.01) reduced the granuloma dry weight when compared to the control. Toddalia asiatica showed good radical scavenging activity at various concentrations (200-1000 μg mL-1) against DPPH with IC50 value of 240.07 μg mL-1, OH radical with IC50 value of 432.17 μg mL-1, NO radical with IC50 value of 324.81 μg mL-1 and the same showed moderate scavenging activity against Chelation of Fe2+ ions with IC50 value of 483.21 μg mL-1. Conclusion: Present study indicates that 50% ethanolic extract of stem bark of Toddalia asiatica (L.) Lam possessed effective anti inflammatory and antioxidant activity.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility