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Articles by M. Tehranipour
Total Records ( 11 ) for M. Tehranipour
  M. Tehranipour and M.R. Khakzad
  The present study has been undertaken the effects of maternal diabetes on Hippocampus structure 1 day neonate individual`s rats from diabetic mothers in both control and diabetic groups. Diabetes was induced by stereptozotocin (60 mg kg-1) given by a single intraperitoneal injection to female Wistar rats. Control rats were injected with phosphate buffered saline. In neonates brains rapidly were removed and in all sample the number of neurons in CA1, CA2, CA3 was measured via stereological method in both control and experimental groups. Statistical analysis determines that there is a meaningful reduction in number of neurons in CA3 in neonate of diabetic mothers (p<0.05). That may be the reason for memory problem in these neonates.
  M. Tehranipour
  In this research, the effect of maternal diabetes on the choroids plexus volume changes and total length of capillaries in (15°, 1-day-old and 30-day-old) rat neonates was studied. Diabetes was induced by streptozotocin (60 mg kg-1), given by a single intraperitoneal injection to female Wistar rats (250-300 g). Control animals were given an equivalent amount of citrate buffer saline. In three stage of life, the volume of choroids plexus and total length of capillaries by stereological methods was measured. Statistical analysis`s showed significant difference in choroids plexus volume and total length of capillary`s between diabetic and control groups (p<0.01). This study shows that maternal diabetes causes microvascular disorders in choroids plexus system that lead to an increase in volumes of that.
  M. Tehranipour , J. Khayyatzade and Z. Ghorbani
  In the present study, we examined the effects of maternal hyperglycemia on the volume of brain and lateral ventricle in newborn Wistar rats. At 7th day of pregnancy hyperglycemia was induced by a single injection (i.p.) of streptozotocin (55 mg kg-1). Control animals were given an equal volume of citrate buffer. After parturition 1 pups were randomly selected from each litter, their brain dissected, fixed in 10% formalin, sectioned in 7 μm thickness and stained by H.E. By applying stereological techniques and systematic random sampling scheme the volume of the brain and lateral ventricles were estimated. In comparison with controls, statistical analysis showed significant increases (p<0.05) in the volume of the brain and lateral ventricles. In conclusion it seems that, maternal diabetes effect on blood brain barrier permeability in newborn rats that could cause large amount of CSF generation. These effects could lead to brain disorders such as hydrocephalus.
  M. Tehranipour and M. Kabiri
  The effect of dental insurance on the ranking of dental needs in older adults has not been reported previously. We examined this effect using data obtained from a cross-sectional survey of older adults living in homes for the aged in Mashhad Region, Khorasan. History of dental insurance was obtained during interviews. Dental needs, assessed during clinical examinations, were ranked from no need to urgent need according to the guideline of the Iranian Dental Association. The associations between the rank of dental needs, dental insurance and other factors were analyzed with the Kruskal-Wallis test, χ2 test, analysis of variance and multiple logistic regressions. Of the 252 participants, 80 (31.7%) had been insured continuously since 2006, 69 (27.4%) had no need for dental treatment and 59 (23.4%) needed urgent dental care. More of the continuously insured than the uninsured residents were dentate (46/80 [57.5%] vs. 75/172 [43.6%], p = 0.04). Ranking of the need for care was not significantly influenced by dental insurance; need of any kind was explained by being dentate (odds ratio 12.3, 95% 15-confidence interval 5.6-27.3).
  M. Tehranipour and M. Kabiri
  There are extensive evidences those axonal processes of the nervous system (peripheral and/or central) may degenerate after nerve injuries. Wallerian degeneration and choromatolysis are the most conspicuous phenomena that occur in response to injuries. In this study the effects of exogenous testosterone administration on peripheral neurons regeneration after sciatic nerve compression in rat was investigated. Thirty-two male Wistar rats divided to 4 group (control, compression, compression+castrated, compression+subcutaneous administration testosterone n = 8). After 4 weeks the lumber segments of spinal cord were sample, processed, sectioned serially and stained with toluidine blue (pH = 4.65). By using sterological quantitative technique (physical dissector), the number of alpha motoneurons in the right ventral horns of spinal cord were counted and compared with each other. Statistical analysis showed that the number of motor neurons in compression group reduced significantly. In castration animal compression induced remarkable reduction in compare with control group. Treatment of testosterone (100 mg kg-1) at 4 week significantly (p<0.05) reduced neuronal damage and testosterone has a neuroprotective effect on motor neurons degeneration after sciatic nerve injury.
  M. Tehranipour and M. Kafaee
  Extremely low-frequency magnetic fields (ELFMF) have been reported to produce a variety of biological effects. In the present study, the effects of extremely low-frequency magnetic field (ELFMF) of 4 μT intensity on spatial memory in mice brain (20 min) with using an platform finding task were examined. Thirty mouse were divided to control, experimental 1, 2 (n = 10). Comparable groups of mice were exposed for 20 min to ELFMF. For similar conditions control group were situated into set of ELFMFs for 20 min but with out exposure of magnetic field. The total time spent exploring the platform in the starting phase for all groups was estimated. Present results demonstrate (Experimental 1, 2) that exposed ELFMF are significantly better in practice related to spatial memory in comparison with control group.
  M. Tehranipour and S. Ebrahimpour
  As the point of physiology, memory form, from changes in the conducting message in the neural webs. These changes cause to formation of long-term potentiation. Δ9-THC is Psychotropic component 4-of Cannabis sativa plant; studies show this matter can bind cannabinoid receptor in CA1 area of hippocampus. Thus the aim of this study is evaluation the effect of aquatic extraction Cannabis sativa seed on spatial 7-memory consolidation in Rats. Forty male wistar Rats (3-4 mounth, 320-260 g) were completely divided into 4 experimental groups and control group. Cannabis sativa seed was extracted with Soxhlet apparatus. To test spatial memory, Morris water mazemaze (7 days, 4 trails) was used. Experimental groups with 50, 100, 150 and 210 mg kg-1 were injected in the peritoneal (IP) and after 1 h of injection spatial memory was scaled. The result show that experimental groups (50, 100 and 150 mg kg-1 doses), for learning time have significant level deduction in the comparison of control group (p<0.05), but experimental group with 18-210 mg kg-1 dose has not significant level in the comparison of control group (p<0.05). This LTP probably was done with Depolarization Induced Suppression of excitatory (DSE) mechanism in the CA1 area of Hippocampus that with neurotransmitter regulation cause to neuroplasticity.
  M. Tehranipour and R. Javaheri
  Wallerian degeneration in the CNS and PNS consists of degradation and phagocytosis of axons and their myelin sheath distal to the site of injury. The present study was undertaken to evaluate the possible antioxidant neuroprotective effect of Curcuma longa extract on neuronal death after sciatic nerve injury in rat. Treatment of Curcuma longa extract (100 mg kg-1, i.p.) at three different times (immediately, 3, 6 and 9 day after compression) significantly (p<0.05) reduced neuronal damage. The present study demonstrates that Curcuma longa extract treatment attenuates sciatic nerve injury and oxidative stress that’s following it. Because of antioxidative effect of Curcuma longa extract; treatment with this immediately or even delayed until 24 h may have the potential role to be used as a protective agent in neurodegenerative process.
  M. Tehranipour
  There are extensive evidences that degeneration process after spinal cord injury could be a good reason for nervous system (peripheral and/or central) problems. In this study the effects of cell administration on Alpha motoneurons regeneration after Spinal Cord Injury (SCI) in rat was investigated. Twenty four male Wistar rats divided to 3 groups (control, Spinal Cord Injury (SCI), (SCI) + stem cell administration n = 8). After 4 weeks the lumber segments of spinal cord were sample, processed, sectioned serially and stained with toluidine blue (pH = 4.65). By using sterological quantitative technique (physical dissector), the number of alpha motoneurons in the right ventral horns of spinal cord were counted and compared with each other. Statistical analysis showed treatment with stem cell at four week significantly (p<0.05) reduced neuronal damage and progress the regeneration. The numerical density in this group is near to control group. Then it is consulted that cell administration could reduce the degeneration rate of Alpha motoneurons after Spinal Cord Injury (SCI) in rat.
  M. Tehranipour and T. Ghadamyari
  The aim of this study is carried out to examine the neuroprotective effects of root aquatic extract of Salvia staminea on neuronal density of motoneuron in spinal cord anterior horn in rats. Forty adult male Wistar rats were used and divided to five groups (control, compression, three experimental groups). In compression and experimental groups right sciatic nerve were highly compressed for 60 sec, assigned to experimental groups (Compression + aquatic extract of Salvia root injections (25, 50, 75 mg kg-1, i.p., 4 time) (N = 8). After 4 weeks post-operative the lumbar segments of spinal cord were sampled, processed, sectioned serially and stained with toluidine blue (pH 4.65). By using stereological quantitative technique, the number of alpha motoneurons in the right horn of spinal cord were counted and compared with each other. Statistical analysis showed remarkable increase in the number of alpha motoneurons in the groups with dosage (50, 75 mg kg-1) in compared to compression. Result shows that root aquatic extract could increase neuronal density motoneuron in anterior horn of spinal cord after sciatic nerve injury in rat.
  M. Tehranipour and M. Erfani
  Background: Wallerian degeneration in the CNS and PNS consists of degradation and phagocytosis of axons and their myelin sheath distal to the site of injury that progress in diabetic condition. Context and purpose of the study: The present study was undertaken to evaluate the effect of Curcuma Longa alcoholic extract on cell regeneration (neurons and neuroglias) after sciatic nerve injury in diabetic rats. Forty rats were divided to five groups (control, compression and three experimental groups). In compression and experimental groups right sciatic nerve were highly compressed for 30 s, assigned to experimental groups (Diabetic+Compression+Curcumin extract injections (0, 25, 50 mg kg-1, i.p., 3 time) (N = 8). After 4 weeks post-operative the lumbar segments of spinal cord were sampled, processed, sectioned, stained and the number of cells were counted by stereological study. Results: Statistical analyses showed remarkable increase in the neuronal and neuroglias density in the all experimental groups. Conclusions: This effect of Curcuma longa extract is for antioxidative effect. This effect has the potential role to protect the neurons in neurodegenerative process in diabetic condition.
 
 
 
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