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Articles by M. Tanaka
Total Records ( 5 ) for M. Tanaka
  T Shimizu , S Inomata and M. Tanaka
  Background

Progesterone has long been known to have central effects, by reduced anaesthetic requirements as measured by minimum alveolar concentration (MAC) in various settings. However, other studies have contradicted these findings. Therefore, we compared the effect of progesterone on anaesthetic requirements in a mouse model.

Methods

Male C57BL/6 mice were treated with either progesterone (37.5 or 75 mg kg–1) or the olive oil vehicle, 1 h before each experiment. Animals were placed in a revolving cylinder (4 rev min–1) and supplied with oxygen and stepwise increasing concentrations of sevoflurane. The number of complete rollovers during revolution of the chamber was counted as a measure of anaesthetic requirement.

Results

S.C. administration of progesterone 75 mg kg–1 significantly reduced sevoflurane requirement (P<0.0001). Progesterone 37.5 mg kg–1 did not change sevoflurane requirement.

Conclusions

We conclude that administration of exogenous progesterone injection at higher concentrations decreases anaesthetic requirement as defined by rolling response.

  S Inomata , T Maeda , T Shimizu , T Satsumae and M. Tanaka
  Background

Sevoflurane can be used as a sole agent for intubation in children, but studies have suggested that it is associated with emergence agitation. Fentanyl infusions can be used both to facilitate intubation and decrease emergence agitation. We investigated the effects of fentanyl on conditions at intubation and on emergence from sevoflurane anaesthesia without confounding nitrous oxide or premedication.

Methods

IRB approval and informed consent were obtained. Subjects comprised 150 ASA physical status I or II (age, 2–6 yr). Anaesthesia was induced with sevoflurane in oxygen and maintained using a predetermined concentration of sevoflurane. Subjects were randomly allocated to receive one of three doses of fentanyl: vehicle only (control group), a bolus dose of 1 µg kg–1 followed by a continuous infusion of 0.5 µg kg–1 h–1 (F1 group), or a bolus dose of 2 µg kg–1 followed by a continuous infusion of 1 µg kg–1 h–1 (F2 group). Sevoflurane minimum alveolar concentration for tracheal intubation (MACTI) and emergence agitation score were assessed.

Results

MACTI values were 2.49%, 1.61%, and 1.16% in control, F1, and F2 groups, respectively (P<0.05). Agitation scores were 11.5, 7.0, and 2.6 in control, F1, and F2 groups, respectively (P<0.05).

Conclusions

Fentanyl infusion consisting of a bolus dose of 2 µg kg–1 followed by a continuous infusion of 1 µg kg–1 h–1 facilitates tracheal intubation and smooth emergence in children anaesthetized using sevoflurane.

Clinical trial registration: this study was started in 2000 and was finished in 2008. We had no registration number. IRB approval was obtained.

  M. Fukui , M. Tanaka , M. Yamazaki , G. Hasegawa , M. Nishimura , N. Iwamoto , T. Ono , S. Imai and N. Nakamura
  Aims: Previous studies have implicated reduced serum bilirubin concentrations in the development of cardiovascular disease. The aim of this study was to examine whether bilirubin may explain the high incidence of vascular complications in haemodialysis patients with Type 2 diabetes. Methods: We compared serum bilirubin concentrations, as well as other known aetiological risk factors for cardiovascular disease, in 206 Type 2 diabetes patients on haemodialysis with those in 741 Type 2 diabetes patients not receiving haemodialysis, and evaluated the association between serum bilirubin concentration and cardiovascular disease incidence. Results: Incidences of cardiovascular disease and systolic blood pressure were higher; however, BMI and serum total cholesterol were lower in haemodialysis patients compared with those in patients without haemodialysis. Serum total (0.30 ± 0.10 vs. 0.74 ± 0.26 mg/dl, 0.005 ± 0.002 vs. 0.013 ± 0.004 mmol/l, P < 0.0001) and indirect (0.17 ± 0.08 vs. 0.70 ± 0.23 mg/dl, 0.003 ± 0.001 vs. 0.012 ± 0.004 mmol/l, P < 0.0001) bilirubin were lower in haemodialysis patients compared with those in patients without haemodialysis. Stepwise regression analysis demonstrated that age (β = 0.109, F = 5.959, P < 0.05), duration of diabetes (β = −0.112, F = 6.048, P < 0.05), sex (β = −0.123, F = 8.623, P < 0.05), cardiovascular disease events (β = −0.099, F = 5.131, P < 0.05) and presence of haemodialysis (β = −0.626, F = 201.727, P < 0.01) were independent factors for serum total bilirubin. Logistic regression demonstrated that age (OR 1.089, 95% CI 1.044-1.136; P < 0.0001), duration of diabetes (OR 1.029, 95% CI 1.001-1.059; P = 0.0423), body mass index (OR 1.115, 95% CI 1.001-1.242; P = 0.0487), habit of smoking (OR 2.445, 95% CI 1.046-5.716; P = 0.0391) and serum total bilirubin (OR 0.192, 95% CI 0.037-0.989; P = 0.0484) were independent factors for cardiovascular disease events. Conclusions: Low serum bilirubin concentration could be one of the important factors for the high incidence of cardiovascular disease in Type 2 diabetes patients receiving haemodialysis.
  M. Hiramatsu , M. Oguri , K. Kato , T. Yoshida , T. Fujimaki , H. Horibe , K. Yokoi , S. Watanabe , K. Satoh , Y. Aoyagi , M. Tanaka , H. Yoshida , S. Shinkai , Y. Nozawa , T. Murohara and Y. Yamada
  Aims  We previously showed that the C[RIGHTWARDS ARROW]T polymorphism (rs6929846) of BTN2A1 was significantly associated with myocardial infarction in Japanese individuals by a genome-wide association study. Given that diabetes mellitus is an important risk factor for myocardial infarction, the association of rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to diabetes. The purpose of this study was to examine the relation of rs6929846 of BTN2A1 to Type 2 diabetes mellitus.

Methods  A total of 8650 Japanese individuals from two independent subject panels were examined: Panel A comprised 1141 individuals with Type 2 diabetes and 3161 control subjects and panel B comprised 1664 individuals with Type 2 diabetes and 2684 control subjects.

Results  The chi-square test revealed that rs6929846 of BTN2A1 was significantly related to the prevalence of Type 2 diabetes in subject panel A (P = 0.0002) and subject panel B (P = 0.006). Multivariable logistic regression analysis with adjustment for age, sex, body mass index and smoking status revealed that rs6929846 was significantly associated with Type 2 diabetes (P = 0.0006; odds ratio 1.25) in all individuals, with the T allele representing a risk factor for this condition. Multiple regression analysis with adjustment for age, sex and body mass index revealed that rs6929846 was significantly (P = 0.04) related to blood glycosylated haemoglobin content in control subjects.

Conclusions BTN2A1 may be a susceptibility gene for Type 2 diabetes in Japanese individuals.

  M. Fukui , M. Tanaka , H. Toda , H. Okada , M. Ohnishi , S. Mogami , Y. Kitagawa , G. Hasegawa , T. Yoshikawa and N. Nakamura
  Aims  Serum androgen concentration is reported to be low in patients with Type 2 diabetes. There have been no studies comparing andropausal symptoms such as sleep disturbance, depression, erectile dysfunction and lower urinary tract symptoms simultaneously between men with Type 2 diabetes and subjects without diabetes.

Methods  We compared andropausal symptom scores such as the Pittsburgh Sleep Quality Index, the Self-Rating Depression Scale, the International Index of Erectile Function and the International Prostate Symptom Score in 296 men with Type 2 diabetes and in 267 subjects without diabetes. Furthermore, we evaluated relationships of andropausal symptom scores to various anthropometric factors and compared andropausal symptom scores according to diabetic complications in men with Type 2 diabetes.

Results  Andropausal symptom scores such as the Pittsburgh Sleep Quality Index, the Self-Rating Depression Scale, the International Index of Erectile Function and the International Prostate Symptom Score were 4.2 ± 2.6 vs. 5.0 ± 3.3, P < 0.01 by unpaired Student's t-test, 34.8 ± 8.2 vs. 38.4 ± 9.3, P < 0.0001, 11.5 ± 6.4 vs. 9.9 ± 6.9, P < 0.01 and 7.3 ± 6.7 vs. 9.0 ± 7.1, P < 0.01 in subjects without diabetes and in patients with diabetes, respectively. The Pittsburgh Sleep Quality Index was higher in patients with neuropathy than without. The Self-Rating Depression Scale was higher in patients with advanced retinopathy. The International Index of Erectile Function was lower in patients with advanced retinopathy and nephropathy. The International Index of Erectile Function was lower and the International Prostate Symptom Score was higher in patients with cardiovascular disease than without.

Conclusions  Our data demonstrated that men with Type 2 diabetes have higher prevalence of andropausal symptoms, especially those with diabetic complications.

 
 
 
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