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Articles by M. Sudhakar
Total Records ( 3 ) for M. Sudhakar
  M. Sudhakar , K. Raja , G. Anathan and P. Sampathkaumar
  The proximate composition (Protein, Carbohydrate and lipid), fatty acids, amino acids and minerals contents were investigated in P. vigil. The aim of this study was to demonstrate the nutritive value of P. vigil crab. The protein, carbohydrate and lipid contents were found (19.5, 1.57 and 1.38%), respectively. Totally 18 amino acids was found, among 10 essential amino acids 9 were recorded and non essential amino acids 9 was reported. The essential and non essential amino acid were totally contributed (8.93 and 10.393 g/100 g), respectively. Fatty acids were analyzed, saturated fatty acids (palmitic acid 0.8141% and stearic acid 0.297%), monounsaturated fatty acid (oleic acid 0.9912%) and polyunsaturated fatty acid (Linoleic acid 1.112% and alpha-linoleic acid 0.7065%) was recorded. Finally, 9 minerals were analyzed (Ca> P> I> Na> K> Cu> Mn> Zn) among these calcium was maximum (15.67 mg g-1) and manganese was minimum (0.2121 mg g-1). The results showed that P. vigil crab is a nutritious food.
  B.V.S. Lakshmi and M. Sudhakar
  The present study was undertaken to evaluate the effect of ethyl acetate extract of fresh rhizomes of Zingiber officinale and dried fresh juice of fresh rhizomes of Zingiber officinale for its protective effects on gentamicin-induced nephrotoxicity in rats. Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of gentamicin 100 mg/kg/day for eight days. Effect of concurrent administration of ethyl acetate extract and fresh juice extract of Zingiber officinale at a dose of 200 mg/kg/day given by oral route was determined using serum creatinine, serum uric acid, blood urea nitrogen and serum urea as indicators of kidney damage. The study groups contained six rats in each group. It was observed that the ethyl acetate extract and fresh juice extract of Zingiber officinale significantly protect rat kidneys from gentamicin-induced histopathological changes. Gentamicin-induced glomerular congestion, peritubular and blood vessel congestion, epithelial desquamation, accumulation of inflammatory cells and necrosis of the kidney cells were found to be reduced in the groups receiving the ethyl acetate and dried fresh juice extract of Zingiber officinale along with gentamicin. The extracts also normalized the gentamicin-induced increase in serum creatinine, serum uric acid, blood urea nitrogen and serum urea levels. This is also evidenced by the histopathological studies. Both the extracts possess significant nephroprotective activity.
  B.V.S. Lakshmi and M. Sudhakar
  This study was conducted to evaluate the anti-stress potential of ethanolic extract of fruits of Lagenaria siceraria in rats. The present study was to investigate the influence of forced swimming endurance stress on swimming endurance time, organ weights and changes in biochemical parameters in rats. The purpose of the study was also to investigate the acute heat stress induced changes in biochemical parameters, adrenal gland weight and stress induced perturbations in blood cell counts in albino Wistar rats. These activities were tested at oral doses of 100-400 mg kg-1 of the extract using Withania somnifera as a standard reference drug. Pretreatment with the extract at different doses significantly (p<0.05) ameliorated the stress-induced variations in this biochemical parameters-serum glucose, triglyceride, cholesterol, BUN and cortisol levels, blood cell counts and organ weights in these stress models. The extract treated animals also showed increase in swimming endurance time. This ability of Lagenaria siceraria to prolong the swimming time and ameliorate the stress induced changes in both stress models, therefore, suggests an antistress and adaptogenic property.
 
 
 
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