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Articles by M. Shittu
Total Records ( 3 ) for M. Shittu
  S.F. Ambali , A.T. Abubakar , M. Shittu , L.S. Yaqub , S.B. Anafi and A. Abdullahi
  Chlorpyrifos (CPF) toxicity has been shown to be partly mediated through induction of oxidative stress. In the present study, experiments were conducted with the aim of evaluating the ameliorative potentials of zinc on CPF-evoked alteration in hematological parameters in Wistar rats. Twenty adult male Wistar rats were divided at random into 4 groups of 5 animals per group. Rats in group I served as the control and were given only soya oil (2 mL kg-1) while those in group II were administered zinc only (50 mg kg-1). Rats in group III were dosed with CPF only (10.6 mg kg-1, ~1/8th of LD50). Those in group IV were co-administered zinc (50 mg kg-1) and CPF (10.6 mg kg-1). The different regimens were administered orally once daily for a period of 8 weeks. At the end of the study period, blood samples collected after sacrificing the animals were analyzed for hematologic parameters such as Packed Cell Volume (PCV), Hemoglobin (Hb), Red Blood Cells (RBC), Mean Cell Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), hemoglobin indices, platelets, absolute and differential White Blood Cell (WBC) counts, neutrophil-lymphocyte ratio and erythrocyte malonaldehyde (MDA) concentration. The results revealed that alterations in the values of PCV, Hb, RBC, platelets, absolute and differential WBC and MDA induced by CPF were ameliorated by co-administration with zinc. In conclusion, the study has shown that attenuations of CPF-evoked alterations in hematological parameters by zinc may be partly mediated through its antioxidant properties.
  M.U. Kawu , L.S. Yaqub , B. Habibu , M. Bello , N.D.G. Ibrahim and M. Shittu
  A 1 1/2 years old apparently healthy Sokoto Red (SR) goat weighing 16 kg was diagnosed with bilateral Cystic Ovarian Follicles (COF) at postmortem carried out 24 h from the onset of standing heat. No follicles or recent copora lutea were visible on the ovaries. The weights of right and left ovaries with their cysts were 32 and 15 g, respectively. The lengths of the right (ROC) and left (LOC) ovarian cysts were 18 and 15 cm, respectively. The circumference of the bulbous ovarian end and the posterior tail-like extensions of the cysts were 12 vs. 2.5 and 6 vs. 2 cm, respectively for the ROC and LOC. The volume of follicular fluid contained in the ROC and LOC were 25 and 9.5 mL, respectively. It was concluded that the ROC had larger weight and dimensions than the LOC.
  M.U. Kawu , L.S. Yaqub , J.O. Ayo , P.I. Rekwot , B. Habibu , M. Tauheed , M.M. Suleiman , M. Shittu , T. Aluwong , H.I. Isa and A. Abdullahi
  The aim of this study was to evaluate the features of induced abortion and post-abortion oestrous cycles pattern following treatment with prostaglandin F (PGF) in Sokoto Red (SR) goats. Twelve apparently healthy goats made up of 6 pregnant and 6 non-pregnant (cycling) does were used for the study. Each doe was given a single intramuscular injection of 7.5 mg PGF. All the 6 pregnant does treated with PGF aborted within 72.0±12.4 h post-treatment. Of the 6 does that aborted, 5 (83.3%) showed oestrus subsequently while 4 (66.7%) out of the 6 non-pregnant does were induced to oestrus. Time interval to induced oestrus was 129.6±36.1 and 50.0±11.5 h for the aborted and non-pregnant does, respectively. Mean duration of oestrus for the aborted and non-pregnant does was 46.9±9.6 and 38.7±4.3 h, respectively. The first and second post-abortion oestrous cycle lengths were 6.5±0.5 and 12.5±8.5 days, respectively. While the first and second post-treatment cycle lengths in the non-pregnant does was 22.5±1.2 and 21.3±0.3 days, respectively. It is concluded that a single dose of 7.5 mg PGF is sufficient to induce abortion and oestrus simultaneously in SR goats. However, the post-abortion cycles are short.
 
 
 
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