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Articles by M. Saifuzzaman
Total Records ( 3 ) for M. Saifuzzaman
  G.M.M. Murshid , M. Moniruzzaman , A.A. Rahman , M. Saifuzzaman and Sarder Nasir Uddin
  Phytochemical analysis of the dried aerial part of Senna tora (L.) Roxb. (Family-Fabaceae) indicated the presence of reducing sugars, tannins, steroids, saponins and gums. The pharmacological interest of these compounds, coupled with the use of this plant in traditional medicine prompted the authors to check Senna tora (L.) Roxb. for its probable antibacterial and analgesic activities. The dried aerial part of the plant was subjected to successive extraction with ethanol and the extract was used to investigate the activities. The extract showed mild antibacterial activity against tested microorganisms in agar diffusion method. The extract, however exhibited significant (p<0.001) inhibition of writhing reflex at the dose of 500 mg kg-1 body weight compared with the standard drug Diclofenac Sodium at the dose of 25 mg kg-1 body weight. The obtained result provided a support for the use of this plant in traditional medicine and its further investigation.
  M.E. Ali , M.A. Salam , M.A. Asad , M. Saifuzzaman and M.M. Sarder
  In this study, 5 weeks old mice weighing 22±2 g were grouped in four, each group consisting of six animals. Group-I, II, III and IV of the animals were fed by a standard diet quantity sufficient, normal diet with dissolved arsenic, arsenic with folic acid mixed and arsenic with vitamin C mixed, respectively. Blood was collected from the sacrificed animals and the blood glucose levels were determined by spectrophotometrically and glucometer. The average blood glucose level of arsenic induced animals was 9.37 mmol L-1 compared to 6.53 mmol L-1 in control animals whereas the blood glucose level of Group-III and Group-IV were 6.73 and 7.03 mmol L-1, respectively. Weight gain of the arsenic induced animals was lower compared to that of the animals fed with normal diet, folic acid mixed diet or vitamin C mixed diet. After sacrifice, the weight of kidney, heart and lung of arsenic induced animals were less than that of the Group-III and Group-IV. The reduction of arsenic induced higher blood glucose level by folic acid and vitamin C demonstrates that folic acid and vitamin C has significant effect in preventing arsenic induced disease.
  M.E. Ali , M.A. Salam , M.A. Asad and M. Saifuzzaman
  Ketoprofen, a widely used analgesic drug is available in two solid dosage forms in the pharma-market of Bangladesh: enteric-coated tablet and capsule of sustained-release pattern. Seven brands of ketoprofen enteric-coated tablets and four brands of ketoprofen sustained release capsules were studied for their in vitro release behavior as well as potency status. From the seven samples of tablets, two brands (KT-03 and KT-07) were found noncompliant in respect of disintegration test in acid stage, whereas all the brands complied with BP (British Pharmacopoeia) specification in buffer stage at pH 6.8. The dissolution study of ketoprofen tablets were carried out in both acid and buffer stages and all the samples satisfied with USP specification in both stages. All of the brands of ketoprofen capsule also complied with the USP specification. Potency was determined by UV spectroscopic method according to BP. Two brands (KT-03 and KT-07) of tablets were found non-compliant, whereas all the brands of capsules exerted compliance in respect of potency.
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