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Articles by M. Panahi
Total Records ( 4 ) for M. Panahi
  S. Razie , M. Panahi , A. Ahangarpor , F. Rahim and G. Saki
  This study was designed to evaluate the ultrastructure of contra lateral testis tissue and measurement of Serum inhibin B following unilateral blunt testis trauma. Twenty pre-pubertal male wistar albino rats aged 3 weeks were divided into 4 equal groups that each containing five rats. Group I was the control group. Group II was used as a Sham group. Group III had right orchiectomy initially. Group IV was the trauma group in which the right testis was placed on a firm sterile surface and the metal rod weighting 100 g was drooped on to the testis from a height of 5.5 cm. Seven weeks after initial operation 3 mL blood samples were obtained from each rat to determine inhibin B levels and contra lateral orchiectomies were performed in all groups to microscopically investigate electron. Inhibin B levels decreased in groups 3 and 4. The difference between group 3 with groups 1 and 2 was significant (p = 0.003 and 0.02). Also the difference between group 4 with groups 1 and 2 was significant (p = 0.006 and 0.002) but the difference between group 3 and 4 was not significant (p = 0.08). In group III (orchiectomy) TEM showed a normal sperm morphology and normal disruption of different stages of the spermatogonial maturation. Debris and vacuolar changes were seen in sertoli cells. Morphology of leydig cells slightly modified and the dilated cisternae of the Smooth Endoplasmic Reticulum (SER) were observed in group IV( trauma) mitochondria with degenerated cristae and enlarged vacuole were observed.
  M. Bazrafkan , M. Panahi , G. Saki , A. Ahangarpour and N. Zaeimzadeh
  In this study the effect of aqueous extract of RG on spermatogenesis of rat has been investigated. Animals were allocated into three groups as: (1) control which did not receive anything, (2) vehicle which received only normal saline (the same volume as 3rd group according to the weight) and (3) experiment which received ruta extract (300 mg kg-1 intraperitoneally once a day for 50 days). A day after last injection the animals were deeply anesthetized and dissected. The right testes were extruded and fixed for histological studies. For statistical analysis ANOVA and Tukey as a post hoc. test were used. There was a significant decrease in the number of spermatogonia (p<0.01), primary spermatocyte (p<0.05), spermatid (p<0.05) and lydig cells (p<0.01) in experimental group as compared to control and vehicle. Also there were a significant increase in thickness of tunica albugina (p<0.01) and decrease in seminiferous tubule diameter (p<0.05) in experimental group compared to control and vehicle. So, it is concluded that the aqueous extract of Ruta graveolens diminishes the reproductive system activity and might be a useful substance for birth control process.
  H.R. Sameni , M. Panahi , A. Sarkaki , G.H. Saki and M. Makvandi
  This study was conducted to investigate the neuroprotective effects of progesterone (PROG) on electrophysiological and histomorphometrical alternation in STZ-induced diabetic neuropathy starting from 4 weeks after the diabetic induction. Thirty adult male Sprague-Dawley rats were randomly divided into 3 groups (with 10 rats in each), control (nondiabetic), untreated diabetic and diabetic PROG-treated. Diabetes was induced in adult male rats by a single dose injection of streptozotocin (STZ, 55 mg kg-1, i.p.). In the PROG-treated group, 4 weeks after induce of diabetes; rats were treated with PROG (8 mg kg-1, i.p., every two days) for 6 weeks. Diabetic rats showed a significant reduction in motor nerve conduction velocity (MNCV), mean myelinated fibers (MFs) diameter, axon diameter and myelin sheath thickness in the sciatic nerve after 6 weeks. In the untreated diabetic group endoneurial edema was observed in sciatic nerve and the numbers of MFs with infolding into the axoplasm, irregularity of fibers, myelin sheath with unclear boundaries and alteration in myelin compaction were also increased. Long-term treatment with PROG increased MNCV significantly and prevented all these abnormalities in treated diabetic rats. Our findings indicated that PROG as a therapeutic approach can protect neurophysiologic and histomorphologic alterations induced by peripheral diabetic neuropathy.
  S. Movassaghi , G. Saki , F. Javadnia , M. Panahi , M. Mahmoudi and F. Rhim
  MBCD and Cholesterol-Loaded-Cyclodextrin (CLC) were examined for their abilities to increase the cryosurvival of C57BL/6 mouse sperm, the main strain of genetically engineered mice. The intactness of acrosome and motility of frozen/thawed spermatozoa were used to monitor cryosurvival. In this experimental study, male mice were randomly divided in 6 groups: control 1, experimental 1, experimental 2, control 2, experimental 3 and experimental 4. In experimental groups 1 and 2 spermatozoa were exposed to 0.75 and 1 mM MBCD and in experimental groups 3 and 4 were exposed to two different concentrations of CLC (1 and 2 mg mL-1) over a period of 1 h and were subsequently cryopreserved. Spermatozoa in control 1 group were frozen without any exposure to CLC or MBCD and in control 2 (vehicle), sperms were incubated with 4 mM MBCD. The post-thaw sperms were evaluated for their motility and acrosomal status. The values of the intact acrosome and motility increased significantly with concentration of CLC compared to controls and MBCD experimental groups (p<0.05). These results indicate that cryosurvival of C57BL/6 mouse spermatozoa is enhanced by exposure to MBCD which loaded with cholesterol (CLC) before freezing and MBCD alone can not protect sperm from freeze-thaw damage efficiently compare to CLC.
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