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Articles by M. Mostofa
Total Records ( 4 ) for M. Mostofa
  M.S. Islam , M.A. Awal , M. Mostofa , F. Begum , A. Khair and M. Myenuddin
  The present study was undertaken for the effect of spirulina on biochemical parameters and reduction of tissue arsenic concentration in arsenic induced toxicities in ducks. One hundred and seventy 5 ducklings were divided into five equal groups separately. One group (T0) of ducklings was kept as control. One group (T1) of ducklings were given arsenic trioxide @ 100 mg/L drinking water and rest three groups of ducklings (T2, T3 and T4) were given arsenic trioxide @ 100 mg/L plus spirulina in three different doses i.e. 30, 60 and 120 mg/L in drinking water daily for 90 days starting from day 15. Five birds were sacrificed from each group in every 15 day intervals and biochemical parameters were determined. All the biochemical parameters (SGPT, SGOT, ALP, LDH and ACP) were significantly (p<0.01) elevated in arsenic treated groups. However, the elevation of these parameters was less in arsenic plus spirulina treated groups (T2, T3 and T4). The distribution of arsenic concentration was highest in liver and lowest in faeces. Maximum reduction of arsenic was recorded in all organs following highest doses of spirulina (120 mg/L). The present study reveals that spirulina may be helpful for reducing the tissue burden of arsenic in ducks.
  M.S. Islam , M.A. Awal , M. Mostofa , F. Begum , A. Khair and M. Myenuddin
  The present study, was undertaken for the effect of spirulina on toxic signs, body weight and hematological parameters in arsenic induced toxicities in ducks. One hundred and 75 ducklings were divided into 5 equal groups separately. One group (T0) of ducklings was kept as control. One group (T1) of ducklings were given arsenic trioxide @ 100 mg/L drinking water and rest three groups of ducklings (T2, T3 and T4) were given arsenic trioxide @ 100 mg/L plus spirulina in three different doses i.e. 30, 60 and 120 mg/L in drinking water daily for 90 days starting from day 15. Five birds were sacrificed from each group in every 15 day intervals and toxic signs, body weight and hematological parameters were recorded. Ducks of T1 group (only arsenic trioxide) showed depression, reduced feed intake, dullness and ruffled feathers which were in mild in nature in other groups i.e. arsenic plus spirulina. In arsenic treated groups (T1) the not gained body weight was maximum (14.93%), whereas in arsenic plus spirulina treated groups (T2, T3 and T4) the not gained body weight in ducks (4.08-11.26%) were better than only arsenic treated groups. Reduction of TEC, Hb and PCV values and rise of ESR values were significant (P<0.01) in T1 (arsenic treated) groups. However, in arsenic plus spirulina treated rest groups reduction of TEC, Hb and PCV were less than arsenic treated groups. The present study reveals that spirulina may be helpful for reducing the body burden of arsenic in ducks.
  K. Rafiq , M. Mostofa and M. Saiful
  The objectives of this studies was to select an ideal anthelmintic which was incorporated in blocks, to know the efficacy of medicated urea molasses mineral block (MUMMB) against gastrointestinal nematode parasites in naturally infested indigenous dairy cows and its cost benefit analysis. To fulfill these objectives naturally infested 72 indigenous dairy cows with gastrointestinal nematode parasites were selected for this study. The cows were offered normal diet added with 250 gm differents block/ cow/ day. Comparative stability trials were carried out with three anthelmintic (albendazole, fenbendazole and thiophanate) on 48 dairy cows. After comparative anthelmintic efficacy trails all three anthelmintic separately mixed with molasses-mixture and kept in laboratory under normal environmental conditions up to 4 months. After 4 months comparative efficacy trails of those anthelmintic incorporated in molasses mixture were done against naturally infested gastrointestinal nematodes parasites in dairy cows. Efficacy of medicated blocks against gastrointestinal nematodiasis was evaluated by examining faecal EPG reduction throughout the licking period, which was compared with pre-treatment EPG value. In this study three types of blocks such as medicated urea-molasses-mineral block(MUMMBa, 0.3gm fenbendazole/kg block), medicated-urea-molasses-mineral blocks (MUMMBb, 0.4gm fenbendazole/kg block) and urea-molasses blocks(UMMB) were prepared. cost benefit analysis of the medicated blocks licks was calculated based on the present cost of ratio components and milk sale value. Fenbendazole was found to be stable in blocks and was selected for the preparation of medicated blocks. Medicated blocks MUMMBa offered to lick by naturally infested dairy cows with gastrointestinal nematode parasites showed EPG reduction from 976.26±98.04 to 70.88±20.99 and when medicated blocks MUMMBb, offered to lick by naturally infested dairy cows with gastrointestinal nematodes parasites, showed EPG reduction from 958.33±102.06 to zero within seven days. The same result still remained during the experiment. Whereas UMMB also reduced EPG about 13.44%. The cost benefit analysis showed that marginally there was increase in the feed cost in medicated block licks group but it was profitable under consideration to milk sale. Prolonged low level administration of fenbendazole through medicated-urea-molasses-mineral blocks were found to have therapeutic and prophylactic effect against naturally infested gastrointestinal nematode parasites of dairy cows. Use of MUMMB instead of UMMB was proved to be better for parasites of dairy cows under the village condition of Bangladesh where balanced ration for dairy cows also was a major scarcity and was found to be cost effective.
  M.A. Hossain , M.R. Akanda , M. Mostofa and M.A. Awal
  Background: Lead (Pb) is one of the toxic substances equally important like other toxic heavy metals. Lead (Pb) has extensive commercial and industrial use despite of public health hazard. Therefore, the work reported here was conducted to detect the therapeutic application of garlic (Allium sativum) on hematological parameters in lead-induced broiler chickens. Materials and Methods: Three hundred and fifty commercial broiler chickens were grouped into 5 such as T0, T1, T2, T3 and T4 consisting of 70 birds each where T0 served as control. T1 was provided with lead acetate at 100 mg kg-1 b.wt., T2 had 100 mg kg-1 lead acetate+1% garlic supplement, T3 was fed with 100 mg kg-1 lead acetate+2% garlic supplement and T4 had 100 mg kg-1 lead acetate+4% garlic supplement with the aim to determine the hematological changes in lead exposed chickens. Results: The analysis of variance in different groups were statistically significant (p<0.01). The mean values of erythrocyte, Hb and PCV values significantly reduced from 2.217±0.020-2.062±0.047, 7.697±0.247-6.172±0.198 and 25.183±0.8122-23.532±1.001, respectively in group T1. The ameliorating effects of garlic in heavy metal lead (Pb) revealed most significant (p<0.01) increased erythrocyte, hemoglobin and Packed Cell Volume (PCV) values from 2.16±0.034-2.46±0.077, 8.362±0.262-10.44±0.26 and 23.64±0.90-30.68±0.75 in group T3, respectively. Similarly Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH) and Mean Corpuscular Hemoglobin Concentration (MCHC) were also resulted increased mean values from 121.12±5.28-131.50±3.72, 38.83±1.38-47.86±1.76 and 14.03±0.89-17.55±1.03, respectively in group (T3). Present study also revealed the increased values of leukocytes that might be attributed to the inflammatory process of leukocytes caused by lead (Pb). Significantly (p<0.01) decreased values of leukocytes were observed in group T3 compared to group T2 and T4 due to the ameliorative action of garlic in lead exposed chickens. Garlic in lead (Pb) exposed chickens could be considered as a potent inhibitor of lymphocytic proliferation that was evident in the present study by matured numbers of leukocytes. Conclusion: The consumption of certain percentages of garlic indicated that it might be capable of enhancing elimination of toxic effects on hematological changes in lead exposed chickens.
 
 
 
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