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Articles by M. Mirinargesi
Total Records ( 2 ) for M. Mirinargesi
  B. Sahar Ansari , R. Vasudevan , M. Mirinargesi , I. Patimah , A.R. Sabariah , P. Pasalar and Ali Bakhshi
  Problem statement: Glutathione S-transferase is super family genes that encode enzymes which involve in the detoxification of the cell and protects DNA from damage. Conflicting results was found in several studies in association with GSTT1 and GSTM1 gene polymorphisms and prostate cancer. In this study, we determined the association between the GSTT1 and GSTM1 gene polymorphism and prostate cancer in Iranian subjects as control with control subjects. Approach: Sixty number of sample were collected from both case and control at Milad hospital, Tehran, Iran who were above 40 years of old. Genomic DNA was extracted from blood and the detection of GSTT1 and GSTM1 genotypes was done using multiplex PCR method. Results: The frequency of the null alleles in GSTT1 and GSTM1 was 15 and 41.66% respectively in prostate cancer patients and 21.66 and 56.66% respectively in control subjects. There was no association was found between the polymorphism and prostate cancer among Iranian subjects (p>0.05). Conclusion: This study failed to show an association with GSTT1 and GSTM1 gene polymorphisms and prostate cancer and has no susceptibility to Iranian prostate cancer subjects.
  M. Eghbali , M. Ghane , M. Mirinargesi and A. Zare Mehrjardi
  Epstein Barr Virus (EBV) infects more than 90% of the world's human population. An association is proposed between EBV infection and occurrence of breast cancer, with a large difference in the results reported by different researchers. This study aimed to investigate the frequency of EBV among benign and malignant breast tumors. A total of 24 carcinomas and 24 fibroadenomas paraffin embedded tumoral tissue samples were obtained from the pathology sections of Toos and Firoozgar hospitals in Tehran, Iran. All samples had been collected from patients from June 2011 to February 2012. DNA was extracted from all samples and their infection with EBV was examined by PCR technique. The results obtained by this study showed that 4 out of 24 carcinoma samples (16.6%) were infected by EBV, while the number of fibroadenoma samples infected by this virus was 1 (4.1%). The frequency of EBV infection was different among malignant and benign tumors. However, no association was observed between EBV infection and the formation of malignant or benign tumors based on the Chi-square test. In relation to some other studies, this analysis does not confirm any association between EBV infection and breast cancer occurrence. However, due to the high frequency of EBV infection among breast cancer patients, future studies are needed to elucidate the possible role of the virus in the disease.
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