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Articles by M. Lynch
Total Records ( 2 ) for M. Lynch
  A. Kroneman , L. Verhoef , J. Harris , H. Vennema , E. Duizer , Y. van Duynhoven , J. Gray , M. Iturriza , B. Bottiger , G. Falkenhorst , C. Johnsen , C.-H. von Bonsdorff , L. Maunula , M. Kuusi , P. Pothier , A. Gallay , E. Schreier , M. Hohne , J. Koch , G. Szucs , G. Reuter , K. Krisztalovics , M. Lynch , P. McKeown , B. Foley , S. Coughlan , F. M. Ruggeri , I. Di Bartolo , K. Vainio , E. Isakbaeva , M. Poljsak-Prijatelj , A. Hocevar Grom , J. Zimsek Mijovski , A. Bosch , J. Buesa , A. Sanchez Fauquier , G. Hernandez-Pezzi , K.-O. Hedlund and M. Koopmans
  The Foodborne Viruses in Europe network has developed integrated epidemiological and virological outbreak reporting with aggregation and sharing of data through a joint database. We analyzed data from reported outbreaks of norovirus (NoV)-caused gastroenteritis from 13 European countries (July 2001 to July 2006) for trends in time and indications of different epidemiology of genotypes and variants. Of the 13 countries participating in this surveillance network, 11 were capable of collecting integrated epidemiological and virological surveillance data and 10 countries reported outbreaks throughout the entire period. Large differences in the numbers and rates of reported outbreaks per country were observed, reflecting the differences in the focus and coverage of national surveillance systems. GII.4 strains predominated throughout the 5-year surveillance period, but the proportion of outbreaks associated with GII.4 rose remarkably during years in which NoV activity was particularly high. Spring and summer peaks indicated the emergence of genetically distinct variants within GII.4 across Europe and were followed by increased NoV activity during the 2002-2003 and 2004-2005 winter seasons. GII.4 viruses predominated in health care settings and in person-to-person transmission. The consecutive emergence of new GII.4 variants is highly indicative of immune-driven selection. Their predominance in health care settings suggests properties that facilitate transmission in settings with a high concentration of people such as higher virus loads in excreta or a higher incidence of vomiting. Understanding the mechanisms driving the changes in epidemiology and clinical impact of these rapidly evolving RNA viruses is essential to design effective intervention and prevention measures.
  S. Zhang , M. Lynch , A.M. Gokhale and M. Liu

Microstructural characteristics of porous LSM/YSZ composite cathodes greatly influence the performance of solid oxide fuel cells. The triple phase boundaries, for example, account for a significant portion of the electrochemically active sites in these porous composite cathodes. Nonetheless, experimental characterization of the relevant microstructural attributes has been problematic due to lack of suitable microscopy techniques for simultaneous observations of all three phases (i.e., LSM, YSZ, and porosity) needed for identification and unbiased characterization of the triple phase boundaries. In this contribution it is shown that a combination of chemical etching and atomic force microscopy clearly reveals all three phases and the triple phase junctions in the microstructural sections. Further, stereological techniques based on the geometric probabilities of stochastic geometry enable unbiased statistical estimation of total triple phase boundary length per unit volume and other microstructural attributes from simple counting measurements performed on representative microstructural sections.

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