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Articles by M. Kumawat
Total Records ( 1 ) for M. Kumawat
  P.K. Misra , S. Dalal , M. Kumawat and S. Kharb
  Recent studies have defined the role of trace elements such as iron, calcium, zinc and copper in the formation of gallstones and deficiencies of serum iron and serum calcium can lead to increased risk of gallstone disease. The present study was planned to analyse the exact role of serum iron and calcium in the pathogenesis of gallstone disease and to assess the relationship of biliary cholesterol supersaturation with levels of serum iron and calcium. Total 100 patients suffering from cholelithiasis were included in the study and were divided into following groups based on their serum iron and calcium levels; group A included patients with normal serum iron (the controls), group B included patients with iron deficiency (the cases), group A1 included patients with normal serum calcium (the controls) and group B1 included patients with calcium deficiency (the cases). The 5 mL of blood sample was drawn intravenously before cholecystectomy, serum was analysed for the parameters like serum iron, calcium, cholesterol and biliary cholesterol (lipid extract from bile). Bile cholesterol levels were raised in group B and group B1 (the cases) as compared to group A and group A1 (the controls). Low serum iron, causes defective hepatic cholesterol metabolism and more stasis of bile because of decreased motility of gallbladder and leads to increased precipitation of cholesterol and hence gallstone formation. Also, deficiency of both iron and calcium is associated with increased chances of super-saturation of bile in gallbladder followed by increase in incidence of gallstone formation.
 
 
 
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