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Articles by M. Kiendrebeogo
Total Records ( 7 ) for M. Kiendrebeogo
  A.Y. Coulibaly , J.H. Bationo , Fatouma Mohamed Abdoul-Latif , Bakasso Sahabi and M. Kiendrebeogo
  Background and objectives: Scoparia dulcis is a medicinal herb traditionally used to relieve dementia disorders in Burkina Faso. A female Wistar rats model was used against hydroacetonic extract of Scoparia dulcis to assess the effect of neuroprotective, hepatoprotective and renoprotective. Materials and Methods: The rats were divided into 5 groups with 6 animals/group. Carboxymethyl cellulose (CMC, 0.5%) was used as vehicle to treat the animals by oral route with silymarin or the plant extract. Seven days later, they were intoxicated by intra-peritoneal injection of carbon tetrachloride (2 mL kg1) for 24 h. Then blood, brain, kidney and liver were taken for further analysis. Results: It resulted on a neuroprotective effect noted by an increase in acetylcholinesterase level, a hepatoprotective effect was also registered with a significant decrease in triglycerides, cholesterol, alanine amino-transferase (ALT), aspartate amino-transferase (AST), superoxide dismutase (SOD) and malondialdehyde (MDA). The renoprotective potential was marked by a decrease of urea, uric acid and creatinine. Conclusions: Scoparia dulcis can be a suitable candidate for investigation of neuroprotective agents.
  P.A.E.D. Sombie , A. Hilou , A.Y. Coulibaly , A. Tibiri , M. Kiendrebeogo and O.G. Nacoulma
  The purpose of the present study was to investigate the protective effects of the extracts against H2O2-induced hemolysis of erythrocytes and the neuroprotective potential from galls of Guiera senegalensis. Ethyl acetate fraction of aqueous decoction extract (EAF/ADE) significantly (p<0.05) inhibited lipid peroxidation in rat’s brain homogenate in vitro (37.79±0.93% at 1.25 mg mL-1) when compared to the gallic acid and quercetin used as positive controls and has the best anti-acetylcholinesterase activity (64.02±4.07% at 100 μg mL-1). Under the oxidative action of H2O2, the extracts from galls of G. senegalensis showed significant protection of the erythrocyte membrane from hemolysis. The Aqueous Decoction Extract (ADE) contains the highest amount of total tannin (25.3±1.55 mg TAE/100 mg of extract) content. The erythrocytes hemolysis inhibitory property from galls of G. senegalensis seems to be related weakly to its total tannin content (p<0.05). The present study thus suggested that the galls from G. senegalensis could be used as a new potential source of natural neuro-protective and antioxidant components.
  S. Bakasso , A. Lamien-Meda , C.E. Lamien , M. Kiendrebeogo , J. Millogo , A.G. Ouedraogo and O.G. Nacoulma
  Aqueous acetone extracts prepared from five Indigofera species of Burkina Faso, namely Indigofera colutea (Burm.) Murril., I. macrocalyx Guilld et Perr., I. nigritana Hook f., I. pulchra willd. and I. tinctoria L., were investigated for their phytochemical composition and their antioxidant activities. Standard methods and TLC were used to screen the phytochemical composition. The total phenolic and flavonoid content of extracts were assessed by Folin-Ciocalteu and AlCl3 methods, respectively. These extracts were also evaluated for their antioxidant potentials using ferric reducing antioxidant power (FRAP), 2,2-diphenyl-l-picrylhydrazyl (DPPH) and 2,2`-azinobis(3-ethylbenzothiazoline-6-sulphonate) (ABTS) assays. Flavonoids, saponins, quinones, sterols/triterpenes and tannins were present in all these species except for I. pulchra where quinones were not found. Gallic acid, caffeic acid, rutin and myricetin in I. colutea; gallic acid, quercitrin, myricetin in I. tinctoria; galangin and myricetin in I. macrocalyx were identified by thin layer chromatography. Among these, I. colutea, I. tinctoria, I. nigritana and I. macrocalyx, which had the highest phenolic content, were also found to possess the best antioxidant activities. The results indicated a good correlation between antioxidant activities and total phenolic content (p<0.05 for FRAP/DPPH and DPPH/ABTS and p<0.01 for FRAP/ABTS). These plants represent promising sources of natural antioxidants and these findings give scientific bases to their ethnopharmacological uses.
  T.H. Coulidiati , H. Millogo-Kone , A. Lamien-Meda , C.E. Lamien , M. Lompo , M. Kiendrebeogo , S. Bakasso , M. Yougbare-Ziebrou , J. Millogo-Rasolodimby and O.G. Nacoulma
  In this study, the antioxidant and antibacterial activities of acetone extract, ethyl acetate, n-butanol and n-hexane fractions of acetone extract from leaves of Combretum nioroense Aubrév. ex Keay were investigated. The total phenolics and total flavonoids contents in the fractions and acetone extract were determined by spectrophotometric methods using Folin-Ciocalteu and AlCl3, respectively. Two methods were adopted to assess the antioxidant activities: the Ferric Reducing Antioxidant Power (FRAP) and the radical scavenging activity of 2, 2’-azinobis (3-ethylbenzothiozoline-6-sulfonate) radical cation (ABTS). The Minimum Inhibitory Concentrations (MICs) of the extract and fractions against pathogenic bacteria (4) and serotyped bacteria (4) from American Type Culture Collection (ATCC) were also determined using the agar-well diffusion method. The results showed that the butanol fraction, with the highest phenolic content, exhibited the best antioxidant and antibacterial activities as compared to the ethyl acetate fraction which contains more flavonoids.
  N.T.R. Meda , A. Lamien-Meda , M. Kiendrebeogo , C.E. Lamien , A.Y. Coulibaly , J. Millogo-Rasolodimby and O.G. Nacoulma
  The present study aimed to test the validity of Balanites aegyptiaca remedies used for the treatment of rheumatisms and mental disorders by examining the antioxidant, xanthine oxidase and acetylcholinesterase inhibitory activities of galls and leaves extracts and fractions. The total phenolics and flavonoids were measured using Folin-Ciocalteu and AlCl3 reagents, respectively. Two methods i.e., FRAP and ABTS were used to estimate the total antioxidant capacity of the plant materials. The FRAP and ABTS antioxidant activities showed that among all extracts and fractions tested, the best antioxidant activities were found with the galls dichloromethane and the leaves ethyl acetate fractions. The antioxidant activities did correlated significantly with the total phenolic and flavonoid contents. The study also showed that B. aegyptiaca galls and leaves fractions exhibited a moderate xanthine oxidase inhibitory activity comparatively to the acetylcholinesterase which was weakly inhibited by the tested extracts and fractions.
  K. Konate , A. Souza , A.Y. Coulibaly , N.T.R. Meda , M. Kiendrebeogo , A. Lamien-Meda , J. Millogo-Rasolodimby , M. Lamidi and O.G. Nacoulma
  In this study polyphenol content, antioxidant activity, lipoxygenase (LOX) and Xanthine Oxidase (XO) inhibitory effects of n-hexane, dichloromethane, ethyl acetate and n-butanol fractions of aqueous acetone extracts from S. alba L., S. acuta Burn f. and Cienfuegosia digitata Cav. were investigated. The total phenolics, flavonoids, flavonols and total tannins were determined by spectrophotometric methods using Folin-ciocalteu, AlCl3 reagents and tannic acid, respectively. The antioxidant potential was evaluated using three methods: inhibition of free radical 2,2-diphenyl-1-picrylhydramzyl (DPPH), ABTS radical cation decolorization assay and Iron (III) to iron (II) reduction activity (FRAP). For enzymatic activity, lipoxygenase and xanthine oxidase inhibitory activities were used. This study shows a relationship between polyphenol contents, antioxidant and enzymatic activities. Present results showed that ethyl acetate and dichloromethane fractions elicit the highest polyphenol content, antioxidant and enzymatic activities.
  P.A.E.D. Sombie , A. Hilou , C. Mounier , A.Y. Coulibaly , M. Kiendrebeogo , J.F. Millogo and O.G. Nacoulma
  The galls of Guiera senegalensis J.F. Gmel (Combretaceae) are used in Burkina Faso traditional medicine to treat some microbial and metabolic diseases such as malaria, dysentery, diabetes and hypertension. The purpose of the present study was to investigate the phytochemical analysis, the antioxidant and anti-inflammatory inhibitory activities from the galls of Guiera Senegalensis. Phytochemical assay was conducted with following standard protocols. The method of DPPH, FRAP, β-carotene assay, anti-lipid peroxidation (according to the thiobarbituric acid method) studies in vitro were employed to assess the antioxidant efficacy. The xanthine oxidase and lipoxygenase inhibition properties of extracts and fractions were also evaluated to assess the anti-inflammatory activity from galls of Guiera senegalensis. Galls extracts of G senegalensis are rich in totals polyphenol and in totals flavonoid content. The hydroacetonic extract showed the most potent antioxidant activity in FRAP method (10.88±0.86 mmol AEAC g-1) and anti-lipid peroxidation activity (75.06±2.42%) at a concentration of 1.25 mg mL-1. The water fraction of hydroacetonic extract showed the most potent antioxidant activity (6.012±0.13 mmol AEAC g-1 ) in the DPPH radical scavenging method and butanol fraction of hydroacetonic extract in the β-carotene bleaching method (59.00±3.27%) at a concentration of 100 μg mL-1. The highest antioxidant activity can be positively correlated with the highest total phenolics content and also with the highest anti-inflammatory activity of the tested extract/fraction. The present study thus provides a scientific rationale for the traditional use of this plant product to the treatment of metabolic diseases.
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