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Articles by M. Kandaswamy
Total Records ( 2 ) for M. Kandaswamy
  R.T. Narendhirakannan , S. Subramanian and M. Kandaswamy
  The present study was aimed to evaluate the anti-inflammatory potential of Cleome gynandra leaf extract on both acute (carrageenan induced paw edema) and chronic (cotton pellet granuloma) experimental inflammatory models induced in rats. The effect of C. gynandra on adjuvant induced arthritis was also evaluated. The extract at a dose of 150 mg kg-1 body weight was found to possess significant anti-inflammatory activity in all the experimental models and the results were comparable with indomethacin, a standard reference drug. The extract significantly decreased the carrageenan induced paw edema and cotton pellet granuloma. The increased activities of acid and alkaline phosphatase activity and decreased serum level albumin in cotton pellet granulomatous rats were reverted back to near normal levels after treatment with the extract. The extract significantly decreased the lipid peroxide (LPO) content of exudates, liver and spleen and the activity of γ-glutamyl transpeptidase in the exudates of cotton pellet granuloma. Moreover, C. gynandra also significantly suppressed the development of chronic arthritis induced by Freund`s complete adjuvant. These results demonstrated that the ethanolic extract of Cleome gynandra possess anti-inflammatory activity on both acute and chronic inflammation.
  S. Devaraj , D. Saravanakumar and M. Kandaswamy
  New colorimetric chemosensors, 1-[2-{(4-nitrobenzylidene)amino}phenyl]-3-phenylthiourea (1), 1-[2-{(2-hydroxy-5-nitrobenzylidene)amino}phenyl]-3-phenyl thiourea (2) have been synthesized and characterized by spectroscopic techniques and XRD. The molecular structure of receptor 1 was determined by X-ray crystallography and it has the triclinic space group P1 with cell parameters a = 7.2705 A (6), b = 11.0178 A (9) c = 12.0137 (9) A and Z = 2. Anion binding studies carried out using 1H NMR and UV–visible spectrophotometric titrations revealed that these receptors exhibit selective recognition towards F over other halide anions. The selectivity for F among the halides is attributed mainly to the hydrogen-bond interaction of the receptor with F. Receptors 1 and 2 (5 × 10–5 M) show color change from colorless to brown and yellow respectively in the presence of tetrabutylammonium fluoride (TBAF, 5 × 10–3 M). Moreover, F-induced color changes remain the same even in the presence of large excess of Cl, Br, and I. Chromogenic receptors 1 and 2 undergo distinct color changes from colorless to violet (1) or bluish green (2) on gradual addition of Cu(II) and can be used as colorimetric probes for spectrophotometric and visual analysis of Cu(II) in the presence of other transition metal ions such as Mn2+, Co2+, Ni2+ and Zn2+. The binding constant for 2 was found to be higher than that for 1 towards F and Cu(II) ion and this may be due to presence of OH group in 2, which offers extra binding site.
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