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Articles by M. Iqbal Choudhary
Total Records ( 2 ) for M. Iqbal Choudhary
  M. Iqbal Choudhary , S. Adnan , A. Shah and Atta- Ur-Rahman
  Microbial transformation of two anabolic steroids, ethylestrenol (1) and nandrolone (2), were carried out. Ethylestrenol (1), when incubated with Rhizopus stolonifer (TSY 0471), yielded two oxidative metabolites named 17β-ethyl-3β,17β-dihydroxy-19-norndrost-4-ene (3) and 17β-ethyl-17β-hydroxy-19-norandrost-4-en-3-one (4), while incubation of compound 2 with the same fungus yielded two oxidative metabolites, 19-norandrost-4-en-3,17-dione (5) and 6β,17β-dihydroxy-19-norandrost-1,4-dien-3-one (6).
  Amal Al-Aboudi , Mohammad Yasin Mohammad , S. Ghulam Musharraf , M. Iqbal Choudhary and Atta-ur- Rahman
  The microbial transformation of testosterone by the fungi Rhizopus stolonifer and Fusarium lini has been investigated for the first time. The bioconversion reactions observed from R. stolonifer included oxidation of a 17β-hydroxyl group, a hydroxylation at equatorial 11α position, reduction of the double bond at C-4 with oxidation of the methylene at C-6 to the corresponding keto group, and lactonisation of ring D; the latter is the first report of this reaction by a Rhizopus species. Fusarium lini promoted 1-dehydrogenation of the steroid, which has been rarely observed in fungi cultures. The other routes of biotransformations included oxidation of the 17β-hydroxyl group and the hydroxylation at 11α position. These reactions are not common for Fusarium species.
 
 
 
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