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Articles by M. Hasibi
Total Records ( 3 ) for M. Hasibi
  J. Rezaii , 1H. Ashegh , M. Hasibi , M. Behzadi , F. Khodadadi and M. Heidarali
  The aim of this study was to evaluate the role of Helicobacter pylori infection in relation with p53 and Ki-67 mutations in a case-control study in Iran, an endemic region for H. pylori infection. Sixty nine cases with gastric cancer and 96 cancer-free control subjects with either gastric ulcer or chronic gastritis were studied. Age, sex, H. pylori serology and presence of p53 and Ki-67 mutations were determined for all subjects. There was no significant difference between the groups for age (p = 0.17) but the groups were significantly different regarding sex (p = 0.004). The frequency of H. pylori seropositivity and presence of p53 mutation were more common in case group (p<0.001 and p<0.001) while the difference between groups was not statistically significant for presence of Ki-67 mutation (p = 0.61). After multivariate analysis the effect of p53 mutation (p<0.001, adjusted OR = 126.56, 95% CI: 28.58-560.40) and Ki-67 mutation (p = 0.02, adjusted OR = 0.21, 95% CI: 0.05-0.84) remained significant. H. pylori seropositivity lost its role in the presence of gastric cancer after multivariate analysis and the presence of p53 and Ki-67 were independent affecting factors for gastric cancer even in an endemic region for H. pylori such as Iran.
  M. Hasibi , A. Amirzargar , S. Jafari , A. Soudbakhsh , M. Hajiabdolbaghi , A. Rashidi and M. Gharouni
  The aim of study was to determine the diagnostic value of Polymerase Chain Reaction (PCR) and Enzyme Linked Immunosorbent Assay (ELISA) in 37 confirmed cases of brucellosis and 78 healthy controls. The diagnosis of brucellosis was based on a compatible clinical picture plus a positive blood culture and/or an antibody titer of≥1:160 at the serum agglutination test. Controls were asymptomatic individuals with negative blood cultures and no previous history of brucellosis. PCR and ELISA were performed on all samples. PCR was positive in 15 (40.5%) patients and no controls. Mean±SD (range) ELISA IgG levels in patients and controls were 198.9 ± 63.1 (9.7-231.9) IU mL-1 and 14.6±27.2 (0-145.0) IU mL-1, respectively (p<0.001). The area under the receiver operating characteristic curve for distinguishing between cases and controls was 0.977. The cutoff point for ELISA results yielding maximal sensitivity plus specificity was 167.35 IU mL-1. ELISA proved to be a more appropriate diagnostic method than PCR in the series, with sensitivity, specificity, positive predictive value and negative predictive value of 89.2, 100, 100 and 95.1%, respectively.
  M. Gharouni , P. Ebrahimi , M.J. Mahmoodi , M. Hasibi , A. Rashidi and P. Khashayar
  The aim of the present study was to evaluate the association between a subjective measure of physical activity assessed by a Visual Analogue Scale (VAS) and dyslipidemia in an elderly population of Iran. A total of 74 elderly subjects (39 males) aged 65 years and older who referred to the Cardiovascular Department of the Hospital were studied. Physical activity was assessed on a 100 mm VAS according to which patients were then divided in to two groups active (activity score≥50; n = 31) and inactive (activity score<50; n = 43). Body Mass Index (BMI), systolic and diastolic blood pressure, triglycerides, total cholesterol, Low-Density Lipoproteins (LDL) and High-Density Lipoproteins (HDL) were measured by standard methods. TG (p = 0.021) and LDL (p = 0.006) were significantly higher and HDL was significantly lower (p = 0.028) in the inactive group. No significant associations were found for other variables. As the first report from Iran, present results are important given the race differences that exist in response of plasma lipids to exercise training. Limitations of the present study include its cross-sectional, rather than prospective, structure and the relatively small sample size. It remains to be seen whether VAS can be used as a rapid screening tool for the presence of dyslipidemia in the elderly.
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