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The phytochemical constituents and some neuropharmacological
activity of the methanolic leaf extract of Cissus cornifolia (Bak.)
Planch [Family: Vitaceae] was evaluated in mice employing various models.
The preliminary qualitative phytochemical analysis carried out on the
methanolic leaf extract of Cissus cornifolia revealed the presence
of alkaloids, flavonoids, saponins, steroids/terpenoids, stilbenoids and
tannins. The neuropharmacological effects of the methanolic leaf extract
of Cissus cornifolia on CNS were evaluated using diazepam sleeping
time, exploratory behaviour (head dip tests), motor coordination and acute
toxicity studies in mice. The extract at tested doses (10, 20 40 mg kg-1
body weight i.p.) produced reduction in exploratory behaviour (head dip
test), beam walking assay (foot slips) and potentiate the diazepam-induced
sleep in mice; the LD50 was found to be 775.0 mg kg-1
body weight i.p. in mice. These results corroborates with the traditional
usage of this plant as a remedy against mental derangement as confirmed
by the sedative activity expressed by the extract.
