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Articles by M. Chen
Total Records ( 8 ) for M. Chen
  W. Yu , F. Zhang , W. Hu , R. Zhang , C. Wang , J. Lu , F. Jiang , S. Tang , D. Peng , M. Chen , Y. Bao , K. Xiang , C. Hu and W. Jia
 

Aim

There is a close link between electrocardiographic ventricular repolarization QT parameters and Type 2 diabetes. The aim of the present study was to assess the effects of QT-related and diabetes-related variants in KCNQ1 on QT interval in a Chinese population.

Methods

We recruited 2415 patients with Type 2 diabetes and 1163 subjects with normal glucose regulation in the present study. QT interval was obtained and the heart rate-corrected QT interval (QTc) was calculated using Bazett's formula. Four single nucleotide polymorphisms in KCNQ1 were selected (rs12296050, rs12576239, rs2237892 and rs2237895) and genotyped.

Results

 In participants with normal glucose regulation, the minor allele T of rs12296050 was associated with a 3.46-ms QTc prolongation under an additive model (P = 0.0109, empirical P = 0.0498). In patients with Type 2 diabetes, we did not find any association for the single nucleotide polymorphisms.

Conclusions

Our findings indicate that KCNQ1 is associated with QT interval in a Chinese population with normal glucose regulation.

  M Temple Smith , C Hopkins , C Fairley , J Tomnay , N Pavlin , R Parker , D Russell , F Bowden , J Hocking , M Pitts and M. Chen
 

Background. Partner notification for patients diagnosed with chlamydia is a strategy recommended to interrupt transmission of infection, and patients are commonly encouraged by health practitioners to contact their sexual partners themselves. Few studies, however, have ascertained the psychosocial impact of the chlamydia diagnosis and its effect on partner notification.

Methods. In-depth telephone interviews were conducted with 25 women and 15 men aged 18–55 years, diagnosed with chlamydia from clinics in Victoria, Australian Capital Territory and Queensland. Reactions to chlamydia diagnosis, as well as reasons for, and feelings about, telling their sexual partners about this infection were explored.

Results. Common reactions to initial diagnosis were surprise, shock and shame. The majority of both men and women saw partner notification as a social duty. Some cited concerns about their own health and the health of others as a reason for telling partners and ex-partners about the diagnosis. An infrequent reason offered for partner notification was to confront a partner to clarify fidelity. Reasons for not contacting a partner were typically fear of reaction or a lack of contact details. Although participants reported sexual partners exhibiting a variety of reactions when told of the diagnosis, results showed that for almost everyone, the experience of notifying their partner was better than they had expected.

Conclusions. Findings suggested that partner notification by people diagnosed with chlamydia is achievable but that many require support from their health practitioner to achieve the skills and confidence necessary during this difficult time.

  Q Lin , M Li , Z. Y Shen , L. W Xiong , X. F Pan , J. F Gen , G. L Bao , H. F Sha , J. X Feng , C. Y Ji and M. Chen
  Objective

The purpose of this study was to evaluate the value of vascular endothelial growth factor-A and E-cadherin expression as well as other confirmed prognostic factors in predicting the clinical outcome after definitive surgery of pathologic stage I non-small cell lung cancer.

Methods

One hundred and eighty-five consecutive and non-selected patients who underwent definitive surgery for stage I non-small cell lung cancer in our institute were included in this study. Formalin-fixed paraffin-embedded specimens were stained for vascular endothelial growth factor-A and E-cadherin and the correlation between the staining, its clinicopathological parameters and its prognostic power were analyzed statistically.

Results

Of the 185 patients studied, 92 cases (49.7%) were strongly positive for vascular endothelial growth factor-A. Vascular endothelial growth factor-A expression was only related to visceral pleural involvement (P < 0.001). A total of 95 carcinomas (51.4%) were E-cadherin-negative tumors. E-cadherin expression correlated with histology (P < 0.001), tumor size (P = 0.001) and visceral pleural involvement (P < 0.001). In univariate analysis by log-rank test, gender, tumor size, lymphovascular invasion, visceral pleural involvement, vascular endothelial growth factor-A expression and E-cadherin expression were significant prognostic factors (P = 0.003, 0.042, 0.026, 0.035, 0.008 and 0.006, respectively). In multivariate analysis, gender, vascular endothelial growth factor-A and E-cadherin expression maintained its independent prognostic influence on overall survival (P = 0.013, <0.001 and 0.036, respectively).

Conclusions

Expression of vascular endothelial growth factor-A is related to visceral pleural involvement, and E-cadherin expression correlates with histology, tumor size and visceral pleural involvement. Multivariate analysis confirmed gender, vascular endothelial growth factor-A and E-cadherin expression were significant predictive factors for overall survival in completely resected pathologic stage I non-small cell lung cancer.

  C.L. Zhang , Y.H. Wang , M. Xie , M. Chen , X.H. Wang and S.S. Hou
  PCR-SSCP and DNA sequencing was employed to analyze polymorphisms of the mitochondrial coding gene including ND1-6, ND4L, COX 1-3, ATP6 and ATP8 in Chinese Beijing duck and analyze their effects on carcass traits in Beijing duck. The results showed that 4 SNPs (G9259A, T9269C, G9394A and A9601G) were detected in ATP6 gene and 1 SNP (G9902A) was detected in COX 3 gene. The G9902A locus was a nonsynonymous which result in the varation of the coding amino acid (Arg56Gln). The COX 3 locus showed three genotypes (c. 9902GG, c. 9902GA and c. 9902AA) and the frequencies were 0.12, 0.23 and 0.6+5, respectively. The COX 3 locus was significantly associated with carcass traits of Beijing duck (p<0.05).
  L. Wang , K.M. Peng , M. Chen , X.T. Zheng , T.T. Liu , C.Y. Jin and W.W. Cao
  The research was carried out on 1-90 days old African ostrich chicks to study the morphological characteristics of tibia development. The length, weight and Bone Mineral Density (BMD) and the developmental characteristics of microstructure and ultrastructure were measured and analyzed in the research. Results showed: ostrich chicks <90 days grew fast and the length, weight and BMD of the tibia all increased significantly and continuously. In the tibia of 1 day old bird, transitional trabeculae constituted the primary cancellous bone which constituted the early formation of backbone. Lots of osteoblasts cling to the surface of cartilage formed thin primary cancellous bone; transitional bone trabeculae were very thin. In the tibia of 45 days old bird, resorption was very active, transitional bone trabecula was absorbed by osteoclasts and then rebuilded. The calcification process of cartilage matrix was active. In the tibia of 90 days old bird, rudiment of new born compact bone and osteons had already existed but the mature bone was still not formed. The study provides foundation for the further study on the influencing factor about tibia development and its molecular mechanism. Simultaneously, it gives the theoretical basis for breeding disease prevention and treatment.
  T Fujita and M. Chen
 

We demonstrate quantitative electron holographic tomography using a latex sphere as a simple example. Although a simple object is used, we believe that the observations made in this study will lead to further developments in electron holographic tomography. In particular, we make the quantitative interpretation of artifacts caused by incomplete angular information, i.e. a ‘missing wedge’.

  G. Alimonti , C. Arpesella , H. Back , M. Balata , D. Bartolomei , A. de Bellefon , G. Bellini , J. Benziger , A. Bevilacqua , D. Bondi , S. Bonetti , A. Brigatti , B. Caccianiga , L. Cadonati , F. Calaprice , C. Carraro , G. Cecchet , R. Cereseto , A. Chavarria , M. Chen , A. Chepurnov , A. Cubaiu , W. Czech , D. D`Angelo , F. Dalnoki-Veress , A. De Bari , E. De Haas , A. Derbin , M. Deutsch , A. Di Credico , A. Di Ludovico , G. Di Pietro , R. Eisenstein , F. Elisei , A. Etenko , F. von Feilitzsch , R. Fernholz , K. Fomenko , R. Ford , D. Franco , B. Freudiger , N. Gaertner , C. Galbiati , F. Gatti , S. Gazzana , V. Gehman , M. Giammarchi , D. Giugni , M. Goeger-Neff , T. Goldbrunner , A. Golubchikov , A. Goretti , C. Grieb , C. Hagner , T. Hagner , W. Hampel , E. Harding , S. Hardy , F.X. Hartmann , R. von Hentig , T. Hertrich , G. Heusser , M. Hult , A. Ianni , An. Ianni , L. Ioannucci , K. Jaenner , M. Joyce , H. de Kerret , S. Kidner , J. Kiko , T. Kirsten , V. Kobychev , G. Korga , G. Korschinek , Yu. Kozlov , D. Kryn , P. La Marche , V. Lagomarsino , M. Laubenstein , C. Lendvai , M. Leung , T. Lewke , E. Litvinovich , B. Loer , F. Loeser , P. Lombardi , L. Ludhova , I. Machulin , S. Malvezzi , A. Manco , J. Maneira , W. Maneschg , I. Manno , D. Manuzio , G. Manuzio , M. Marchelli , A. Martemianov , F. Masetti , U. Mazzucato , K. McCarty , D. McKinsey , Q. Meindl , E. Meroni , L. Miramonti , M. Misiaszek , D. Montanari , M.E. Monzani , V. Muratova , P. Musico , H. Neder , A. Nelson , L. Niedermeier , S. Nisi , L. Oberauer , M. Obolensky , M. Orsini , F. Ortica , M. Pallavicini , L. Papp , R. Parcells , S. Parmeggiano , M. Parodi , N. Pelliccia , L. Perasso , A. Pocar , R. Raghavan , G. Ranucci , W. Rau , A. Razeto , E. Resconi , P. Risso , A. Romani , D. Rountree , A. Sabelnikov , P. Saggese , R. Saldhana , C. Salvo , R. Scardaoni , D. Schimizzi , S. Schonert , K.H. Schubeck , T. Shutt , F. Siccardi , H. Simgen , M. Skorokhvatov , O. Smirnov , A. Sonnenschein , F. Soricelli , A. Sotnikov , S. Sukhotin , C. Sule , Y. Suvorov , V. Tarasenkov , R. Tartaglia , G. Testera , D. Vignaud , S. Vitale , R.B. Vogelaar , V. Vyrodov , B. Williams , M. Wojcik , R. Wordel , M. Wurm , O. Zaimidoroga , S. Zavatarelli , G. Zuzel and Borexino Collaboration
  Borexino, a large volume detector for low energy neutrino spectroscopy, is currently running underground at the Laboratori Nazionali del Gran Sasso, Italy. The main goal of the experiment is the real-time measurement of sub-MeV solar neutrinos, and particularly of the monoenergetic (862keV) 7Be electron capture neutrinos, via neutrino–electron scattering in an ultra-pure liquid scintillator. This paper is mostly devoted to the description of the detector structure, the photomultipliers, the electronics, and the trigger and calibration systems. The real performance of the detector, which always meets, and sometimes exceeds, design expectations, is also shown. Some important aspects of the Borexino project, i.e. the fluid handling plants, the purification techniques and the filling procedures, are not covered in this paper and are, or will be, published elsewhere (see Introduction and Bibliography).
 
 
 
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