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Articles by M. Badavi
Total Records ( 3 ) for M. Badavi
  M. Badavi , H.A. Abedi , M. Dianat and A. Sarkaki
  Endothelial dysfunction represents a hallmark of diabetic vascular complications. Although, regular exercise training or antioxidants could prevent these complications to some extent, the effects of grape seed extract as an antioxidant alone or combined with exercise on the diabetic induced endothelial dysfunction was not investigated. Therefore, the aim of this study was to determine the combined effect of grape seed extract and exercise training on vascular endothelial function in streptozotocin induced diabetic rats. Forty five male Wistar rats were randomly divided into five groups: Sedentary control, sedentary diabetic, trained diabetic and sedentary or trained diabetic that received 200 mg kg-1grape seed extract. Eight weeks after diabetes induction by streptozotocin (60 mg kg-1) the body weight and blood glucose were measured and mesenteric vascular bed responses to vasoactive agents (acetylcholine, phenylephrine and sodium nitroprusside) were determined. The data have shown that the weight gain, plasma antioxidant capacity and endothelium dependent vasorelaxation to acetylcholine reduced significantly in diabetic animals. However, exercise training combined with grape seed extract improve body weight gain, increase plasma antioxidant capacity, decrease blood glucose and restores vasodilatory response to acetylcholine more significant than exercise training or grape seed extract alone. On the other hand, the vasoconstrictive response to phenylephrine and vasodilatory response to sodium nitroprusside did not change significantly. The data indicated that exercise training and grape seed extract combination had more significant improving effects on endothelial dysfunction than exercise training or grape seed extract alone and may constitute convenient and inexpensive therapeutic approach to diabetic vascular complications.
  F. Hosseini , M.K. Gharib Naseri , M. Badavi , M.A. Ghaffari , H. Shahbazian and I. Rashidi
  Renal ischemia/reperfusion injury is a major cause of acute renal failure. The production of free radicals and reactive oxygen species are important factors contributing to ischemia/reperfusion injury. Thus, scavenging of the excess free radicals can be an important therapeutic approach. The present study examined the protective effect of beta carotene against renal ischemia/reperfusion injury in rat. Male adult Wistar rats (250-300 g) were exposed to 45 min of renal ischemia followed by 4 h of reperfusion. Beta carotene (10, 30 and 100 mg kg-1) or vehicle was administered for 5 days prior to ischemia. Renal function was assessed by plasma and urinary analysis. Present results showed that ischemia/reperfusion injury increased (p<0.05-p<0.001) serum urea and creatinine levels, as well as urinary excretion of protein and calcium and fractional excretion of sodium, while decreased glomerular filtration rate and potassium excretion. However, alterations in these biochemical indices due to ischemia/reperfusion injury were attenuated by beta carotene pretreatment (p<0.05-p<0.001), although not by all doses. Since, beta carotene administration improved renal function, it seems that beta carotene protects renal tissue against ischemia/reperfusion-induced oxidative damage.
  K. Saadipour , A. Sarkaki , H. Alaei , M. Badavi and F. Rahim
  The aim of this study was to investigate the effect of short-term forced exercise protocol on passive avoidance retention in morphine-exposed rats. Effects of morphine on acquisition and retrieval of retention have been proven in the avoidance paradigms. Twenty four male Wistar rats weighing 250-300 g were used in this study. Animals were randomly divided into four groups including: (1) non-morphine-exposed without exercise (nA.nE) (2) non-morphine-exposed with exercise (nA.E) (3) morphine-exposed without exercise (A.nE) and (4) morphine-exposed with exercise (A.E). Rats ran as forced exercise on the motorized treadmill 1 h daily for ten days. Morphine-exposed animals received intraperitoneal morphine during first 5 days of the exercise period and their dependence to morphine was confirmed by naloxane admistration (10 mg kg-1, i.p.) and withdrawal test. After 10 days of forced exercise, step down latency was tested and Inflexion Ratio (IR) was evaluated in each rat. Baseline step down latencies before any morphine exposing or exercise have shown no significant alteration in all groups. Inflexion Ratio (IR) of nA.E group has increased significantly (p<0.001) at 1, 3, 7 and 14 days after receiving shock (learning) compared to nA.nE and A.E groups. Our data showed that short-term forced exercise on treadmill improved retention in both morphine-exposed and non morphine-exposed rats at least up to 7 days and more than 14 days, respectively. Alteration in retention between exercised groups may attribute the release of adrenal stress hormones such as epinephrine and corticosterone because of the emotional arousal.
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