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Articles by M. Asghari
Total Records ( 2 ) for M. Asghari
  M. Poorebrahim , A.H. Hoseinzadeh , M. Omidi , M. Asghari and N. Sanadgol
  Malaria, an infectious diseases, couses in almost 1 million deaths each year over the world. Artemisinin, a sesquiterpene lactone endoperoxide, is one of the most effective antimalarial drugs purified from Artemisia annua L. in China, 1970s. As the low content of this compound in plant many of studies have been focused on using elicitors affecting gene expression involved in artemisinin synthesis pathway. The main step to enhance artemisinin content in plant by using elicitors is characterization of key genes promoter. Cytochrome p450 Reductase (CPR) is one of the key enzymes that plays an important role in artemisinin synthesis pathway. Promoter sequence of key genes involving in artemisinin biosynthesis pathway included ADS, CYP71AV1 and DBR2 was isolated except CPRgene. We used standard Thermal Asymmetric Interlaced Polymerase Chain Reaction (TAIL-PCR) with some modification in thermal cycle numbers to isolate the unknown 5' flanking region of the CPRgene from Artemisia annua. Subsequent bioinformatics analysis to characterize functional cis-acting elements inside the promoter was performed. The 5' flanking sequence of CPR was cloned in pGEM-T Easy vector and sequenced. Subsequent sequence analysis for characterize functional motifs using bioinformatics software indicated a group of putative cis-acting elements such as TATA box, CAAT box, G box, W box and etc., inside the CPR promoter. This sequence was submitted in GenBank databases under the accession number KC243135. Present study demonstrated that characterization of cis-acting response elements can facilitate using elicitors to enhance artemisinin production in plant.
  N. Namazi , A. Tarighat Esfanjani , M. Asghari and A. Bahrami
  Type 2 diabetes is a metabolic disorder which is strongly associated with cardiovascular risk and requires intervention to improve glycemic control and other cardiovascular risk factors. In this study, hydro alcoholic extract of Nettle (Urtica dioica) on some cardiovascular risk factors in type 2 diabetic patients were studied. A randomized single-blind clinical trial of 50 men and women with type 2 diabetes aged 52.39±13.75 years was conducted. Patients were adjusted by age, sex and duration of diabetes, then randomly divided into an intervention and control groups, they received, 100 mg kg-1 day-1 nettle extract or placebo in 3 portions for 8 weeks. Fasting Blood Sugar (FBS), glycated Hemoglobin (HbA1C), Fasting Insulin concentration, Total Cholesterol (TC), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Triglycerides (TG), systolic blood pressure(SBP), Diastolic blood pressure (DBP) were measured, TC/HDL-cholesterol, LDL/ HDL cholesterol ratio , Log (TG/HDL-c) and Insulin Resistance were calculated, at the beginning and end of the study. The data were analyzed by SPSS version 18, p<0.05 was considered significant in all measurement. After 8 weeks, FBS ,HbA1C , TG , Log (TG /HDL-c) and SBP showed a significant decrease and HDL-cholesterol showed a significant increase in the intervention group compared to the control group (p<0.05). The findings of this study suggest that the hydro alcoholic extract of nettle has a beneficial effect on FBS, HbA1C, TG, HDL-c concentration, Log (TG /HDL-c) and SBP in patients with type 2 diabetes after eight weeks intervention.
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