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Articles by M. Asadujjaman
Total Records ( 3 ) for M. Asadujjaman
  M. Belal Hossain , S.M.N. Amin , M. Asadujjaman and Sharmeen Rahman
  This study was carried out to describe the distribution and community pattern of benthic macrofauna collected from two nationally and internationally important islands, Hatiya and Nijhum Dweep in the period of January to June, 2010 using hand-held mud corer (10x10x10 cm) from seven stations. The coarser (order) level of taxonomic resolution was used to investigate the community attributes among the sampling stations. The study yielded a total of 10688.89 ind. m-2 macrofauna from all stations. Ten major taxa were identified from two islands and polychaete being the dominant. The average population density was 1526.98±1453.375 ind. m-2. There was a significant difference (p<0.05) in faunal density between Hatiya and Nijhum Dweep with later having higher mean density. The maximum (1.97) Shannon diversity index was found in St1 and the lowest (1.14) in St5. The highest similarity (76.6%) was found between St2 and St5. Multivariate analysis was conducted at order level of benthos using PRIMER. Bray-Curtis similarity measures among macrozoobenthic communities separated the stations into several cluster groups which was supported by nMDS ordination map.
  M. Badrul Alam , M. Sarowar Hossain , N. Sultana Chowdhury , M. Asadujjaman , Ronok Zahan , M. Monirul Islam , M. Ehsanul Haque Mazumder , M. Ekramul Haque and Anwarul Islam
  The present study was designed to investigate the antioxidant, anti-inflammatory and antipyretic potential of the methanolic extract along with its organic soluble fractions of the fruits of Trichosanthes dioica Roxb. Antioxidant potential of the extract/fractions was evaluated by DPPH (1,1diphenyl-2-picrylhydrazyl) and NO (nitric oxide) scavenging assay method. Ethyl acetate fractions (EtOAc) showed highest scavenging activity in all the methods with IC50 value of 12.32±0.16 and 5.38±0.07 μg mL-1 for DPPH and NO assay method, respectively. In reducing power assay, EtOAc fraction also showed significant (p<0.001) activity. Further, the extract/fractions were studied for their anti-inflammatory (carrageenan induced paw edema in rats) and antipyretic (Brewer’s yeast induced pyrexia) activities at a dose level of 100, 200 and 400 mg kg-1 body weight for MeOH extract. Methanolic extract showed a dose dependent and significant (p<0.005, p<0.05) anti-inflammatory and antipyretic effect. Dichloromethane fraction (CH2Cl2) and Ethyl acetate fractions exhibited similar activity using a dose of 200 mg kg-1 b.wt. in these models. The pharmacological activities of the (CH2Cl2) fraction were lesser than the MeOH extract and other fractions. In addition, total phenolic and flavonoid content and total antioxidant capacity were also determined. Altogether, these results suggest that the MeOH extract and its organic soluble fractions EtOAc could be used as a potential antioxidant, anti-inflammatory and antipyretic agent.
  M.S. Hossain , M.B. Alam , N.S. Chowdhury , M. Asadujjaman , R. Zahan , M.M. Islam , M.E.H. Mazumder , M.E. Haque and A. Islam
  The present study was designed to investigate the antioxidant, analgesic and anti-inflammatory potential of the methanolic extract along with its organic soluble fractions of the herb Eclipta prostrata. In addition, total phenolic and flavonoid content and total antioxidant capacity were also determined. Antioxidant potential of the extract/fractions was evaluated by DPPH (1,1diphenyl-2-picrylhydrazyl), NO (nitric oxide) and ONOO¯ (peroxynitrite) scavenging assay method. Ethyl acetate fractions (EtOAc) showed highest scavenging activity in all the methods with IC50 value of 12.98±0.08, 45.98±0.07 and 14.45±0.18 μg mL-1 for DPPH, NO and ONOO- assay method, respectively. In reducing power assay, EtOAc fraction also showed significant (p<0.001) activity. Further, the extract/fractions were studied for their analgesic (hot plate, tail immersion and acetic acid induced writhing test) and anti-inflammatory (carrageenan induced paw edema in rats) activities at a dose level of 200 and 400 mg kg-1 body weight. Among all the extract/fractions, EtOAc fraction showed a dose dependent and significant (p<0.005, p<0.05) analgesic activity in all the tested method. EtOAc fractions also reduced the paw edema considerably (86.80% inhibition after 3 h, p<0.005, p<0.05) in dose dependent manner compared to carrageenan induced rat. Altogether, these results suggest that the MeOH extract and its organic soluble fractions could be used as a potential antioxidant, analgesic and anti-inflammatory agent.
 
 
 
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