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Articles by M. Arabi
Total Records ( 2 ) for M. Arabi
  A. Dehghan , M. Arabi , S. Nahid and M. Aminlari
  Oxidative stress commonly occurs following heat stress in tropical regions and affects dairy animals. Glutathione protects cells from oxidative damages. This study was carried out to investigate the serum glutathione level in the ram with a fluorometric method and to determine its changes during heat stress condition. Eight mature rams were selected and kept in the same conditions. The rams were maintained during temperate and warm seasons to compare serum glutathione levels during normal and heat stress conditions, respectively. Heat stress was considered when temperature-humidity index was above 84. Serum samples were obtained at 0, 14 and 28 days after beginning of the study during the seasons. Reduced and oxidized glutathione concentrations were determined using a fluorometric assay. The serum concentrations of reduced glutathione in the normal and heat stress conditions were lower than oxidized glutathione. The reduced and oxidized glutathione levels and their ratios were not different between seasons and at different sampling times, although they were significantly changed during sampling times in the normal and heat stress conditions. Present results represent that glutathione levels change during different environmental conditions. It seems that antioxidant defense system was changed to adapt and prevent oxidative stress effects, although needs further researches.
  M. Arabi and M.S. Heydarnejad
  Epidemiological evidence suggests that exposure to industrial metal aerosols is detrimental to the male reproductive system. Oxidative stress has been identified as a crucial factor leading to male factor infertility largely due to peroxidative damage to the sperm cell membrane. The objectives of the present study were to test the effect of mercury in the concentration range from 50 to 800 μmol-1, in vitro, on the sperm membrane and DNA integrity, motility and acrosomal status of human spermatozoa. We found a significant increase in the Lipo Per Oxidation (LPO) indicating the deleterious effect of mercury on the sperm membrane integrity. This effect was prominent at the concentration of 800 μM mercury. There was also a strong negative correlation between LPO rate and percentage of viable spermatozoa (r = -0.941, p<0.001). Data obtained from SCGE assay technique revealed that mercury is capable of inducing DNA breaks in the sperm nuclei. Almost, 88% of DNA breaks were of double-stranded. The correlation between LPO rate and percentage of DNA breaks was found to be 0.918 (p<0.001). Performing the gelatin digestion test indicates that mercury was able to alter the integrity of acrosomal membranes showing an abnormal acrosome reaction. In this regard, a strong correlation was found between LPO rate and percentage of halos (r = -0.893, p<0.001). Taken together, mercury induced membrane impairments, lowered sperm viability, DNA breaks and a decreased rate in the acrosome reaction of human spermatozoa leading to sperm dysfunction. Entering mercury in the male gonads and seminal plasma may exert deleterious effects on the human spermatozoa. Hence, considering the wide spread use of mercury and its compounds, these metals should regarded with more concern.
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