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Articles by M. Anjum Zia
Total Records ( 2 ) for M. Anjum Zia
  Rabis Iqbal , M. Anjum Zia , Tahira Iqbal and Faqir Hussain
  Biodisposition kinetics of levofloxacin was determined in 9 female volunteers following oral administration of 500 mg tablets. The blood samples were collected at specific time intervals. Concentration of levofloxacin in plasma was determined by microbiological assay, that was found to be 2.39 μg/ml having 1.75 SD and 75% CV values. The pharmacokinetic parameters were determined according to single compartment open model. The average absorption rate constant was 2.00 L/h while absorption half life was 0.34 hours. Average Cmax and Tmax values were 2.43 mg/L and 1.60 hours while volume of distribution was 177 L. From Tmax studies, it is concluded that absorption is delayed due to non-fasting. It is suggested that levofloxacin can be administered orally with regard to food. It was observed the elimination half life and total body clear values were 7.40 hours and 16.54 h respectively while total area under curve was found to be 30.2 h.mg/L. It is also suggested that elimination half life is not affected by the presence of absence of food.
  M. Anjum Zia , M. Yaqub , Khalil- ur-Rehman and Tariq Mahmood
  To standardize the indirect ELISA under local conditions, antispecies-antibodies were produced in rabbits. The antibodies against Pasteurella multocida were produced in buffalo calves by injecting the formalin, heat-killed organism_ These antibodies were inoculated into rabbits to produce rabbit-antibuffalo antibodies. These were isolated and partially purified by ammonium sulfate precipitation technique. Protein contents were estimated using Biuret method and the presence of rabbit-antibuffalo antibodies was confirmed and measured through agar gel precipitation test (AGPT). These isolated anti-antibodies were conjugated with horseradish peroxidase by two-step glutaraidehyde method. Ten mg of horseradish peroxidase was applied for the Anti-antibody-Enzyme Conjugate formation and the best results were recorded at 1 :100 and 1.200 dilutions of above conjugate when tested through indirect ELISA for H.S. anti-antibodies.
 
 
 
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