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Articles by M. Ali
Total Records ( 8 ) for M. Ali
  P. Kumar , A. Semalty , S.R. Mir , M. Ali and S. Amin
  The plant Pongamia pinnata (Linn.) Pierre of family Leguminosae sub-family Papilioanaceae was evaluated for its hypoglycemic and hypolipidemic activity in streptozotocin induced diabetic rats. A new difuranoflavonone Compound PP (named Pongamiaflavonol), isolated from methanlolic extract of P. pinnata pods by column chromatography, was also studied for the activity. It was observed that after 14 days of treatment blood glucose level was reduced by 66.34, 54.82, 63.62 and 67.48 % with Std. Glibenclamiade 3 mg kg-1), P. pinnata pods (300 mg kg-1), P. pinnata flowers (300 mg kg-1) and PP (100 mg kg-1), respectively. The lipid profile was also studied and was found to be normalized significantly by both the flowers and pods extracts of P. pinnata and compound PP.
  A. Semalty , M. Semalty , P. Kumar , S.R. Mir , M. Ali and S. Amin
  Pongamia pinnata (family Papilionaceae) has been used for bronchitis, whooping cough, rheumatic joints and quench dipsia in diabetes. This study deals with the isolation of a new hypoglycemic phytoconstituent from P. pinnata pods. The hypoglycemic activity of the isolated phytoconstituent was evaluated in comparison of the methanolic extract of the pods.. Methanolic extract of P. pinnata pods was fractionated by column chromatography and the isolated compounds were identified by spectral analysis. A new compound named Pongamiaflavonylflavonol was isolated from chloroform: methanol (97:3) eluant. This new isolated compound was studied for hypoglycemic activity in streptozotocin induced diabetic rats. Methanolic extract of P. pinnata pods and pongamiaflavonylflavonol showed significant hypoglycemic activity in streptozotocin-induced hyperglycemic rats after oral administration. At the end of 6 h the new compound showed 12.15% reduction in blood glucose level in comparison of extract (11.36%) against the standard (16.93%). It can be concluded that the novel Pongamiaflavonylflavonol isolated from P. pinnata pods may be useful as oral hypoglycemic therapeutic agent. This may serve as a lead compound for development of more potent drugs for clinical use in diabetes.
  M. Thomson , K.K. Al-Qattan , J.S. Divya and M. Ali
  Garlic and ginger have been shown to have positive effects in the streptozotocin (STZ)-induced rat model of diabetes. Diabetic rats were treated with either raw garlic or ginger extract (500 mg kg-1 intraperitoneally (IP)), or aspirin (10 mg kg-1 IP) for 8 weeks. The dramatic weight loss and increased water and food intake as well as urine output of diabetic rats was improved by ginger while garlic treatment of diabetic animals resulted in a modest weight gain and decreased food (but not water) intake and urine output. Blood glucose and serum creatinine, fructosamine and uric acid were significantly elevated in diabetic rats and were significantly lowered by ginger and garlic. In contrast, serum protein, albumin and insulin levels decreased significantly in diabetic rats while the ginger and garlic-treated diabetic rats had increased serum levels of protein, albumin and insulin. Total urine protein, albumin and albumin/creatinine ratio were significantly elevated in diabetic animals and both garlic and ginger treatments resulted in significant decrease. In contrast, urine uric acid was significantly decreased in diabetic rats and significantly elevated by ginger and garlic. Glycated haemoglobin (GHb) levels increased over 3-fold in erythrocytes of diabetic rats with both ginger and garlic-treated rats showing a significant decrease in GHb levels. Aspirin-treated diabetic animals only exhibited a significant decrease in blood glucose after 8 weeks of treatment with no other parameters being significantly changed compared to diabetic controls. This study suggested that ginger and garlic are effective in reversing diabetic symptoms especially in the kidney.
  A.G. Madaki , M. Abdulhameed , M. Mohamad , M. Ali and R. Roslan
  The two-dimensional steady boundary layer flow of a nanofluid past a stretching sheet with a convective boundary condition in the presence of chemical reaction has been studied. The equation of volume fraction concentration consists of the Brownian motion and the thermophoresis effects. The governing equations are simplified via. boundary value approximation and some similarity variables and solved using the Runge-Kutta fourth order method with shooting technique and Homotopy Perturbation Method (HPM) with Pade approximation (HPM-Pade). All the salient parameters on the temperature and concentration profiles have been studied and details are given graphically. Thus, the results found in this study are being compared with the previously published study where an excellent agreement is achieved. As presented on tables. It is found that the reduced Nusselt number is a decreasing function of both generative and destructive chemical reaction γ. While the reduced Sherwood number is a decreasing function when chemical reaction parameter, γ<0 and increases when γ>0.
  M. Aasim Khan , M. Ali and Prawez Alam
  Phytochemical investigation of the fruit peels of Citrus reticulata Blanco (Rutaceae) resulted in the isolation of three new phytoconstituents along with n-hexacosonoic acid. Their structures have been established as 18βH-urs-5,11-dien-3β-ol-11-one-3β-D-glucopyranosyl-(4′→1′′)-D-glucopyranosyl-6′′-(3′′′,4′′′-dihydroxyl)-benzoate (reticulataursenoside), stigmast-5-en-3β-ol-3β-D-glucopyranosyl-4′-eicosanoate (citrusteryl arachidate), and lanost-5-en-3β-ol-3β-D-glucopyranosyl-4′-eicosanoate (citruslanosteroside) on the basis of spectral data analysis and chemical reactions.
  Zeba Khan , M. Ali and Priyanka Bagri
  The phytochemical investigation of the bark of Tectona grandis Linn. afforded a new steroidal glycoside identified as β-sitosterol-β-D-[4'-linolenyl-6'-(tridecan-4'''-one-1'''-oxy)] glucuranopyranoside and three new fatty esters, 7'-hydroxy-n-octacosanoyl n-decanoate, 20'-hydroxy eicosanyl linolenate and 18'-hydroxy n-hexacosanyl n-decanoate, along with the known compounds n-docosane, lup-20(29)-en-3β-ol, betulinic acid and stigmast-5-en-3-O-β-D-glucopyranoside. Their stereostructures have been elucidated on the basis of spectral data analyses and chemical reactions.
  I. Nazish , R.A. Kaskoos , S.R. Mir , S. Amin and M. Ali
  Ruta graveolens L. belonging to family Rutaceae is commonly known as Common rue and locally as Sudab in India. It is an important medicinal plant used in capillary fragility, for eye diseases, as stimulant and emmenagogue. As the herb is used widely in the Indian traditional system, it was thought worthwhile to undertake the standardization of its aerial parts. Aerial parts consist mainly of leaves that are 3-5 inch long, flowers are tetramerous and fruits are 4-5 lobed. In the powdered form it had pungent odor and exceedingly bitter taste. Microscopical examination of powder of aerial parts showed fragments of epidermis, glandular trichomes, stone cells, lignified xylem elements and abundant calcium oxalate crystals. Successive extractive value was highest in aqueous extract (16.08% on dry weight basis). Mean ash values (%) were 8.13 (total), 2.01 (acid insoluble ash) and 1.02 (water soluble ash). Loss on drying was found to be 4.03% and pH values of aqueous extract was 6.74. Bitterness value of aerial parts was 1.28; foaming index was less than 100. Screening of all extracts indicated the presence of all phytoconstituents except saponins. TLC fingerprints of extracts of aerial parts were also developed.
  R.A. Kaskoos , S. Amin , M. Ali and S.R. Mir
  The present study was aimed to describe the fatty acid composition, stability and nutritional characteristics of fixed oil of Olea europaea drupes from Iraq, locally known as Zaytoon. The oil is commonly known as olive oil and is used throughout the world and is believed to have an important role in human health and nutrition. It is considered as one among newer source of edible oil. The oil is classified as generally regarded as safe (GRAS). The fact that there are few reports of analysis of olive oil from Iraq in comparison to other parts of the world also lured us to examine chemically. Fatty acid composition of the olive oil was determined by capillary GC-FID. Thirty fatty acids (95.88%) were identified in the oil. The major fatty acids of the oil were oleic acid (68.07±1.089%), palmitic acid (12.12±0.162%), arachidic acid (9.78±0.155%), docosahexaenoic acid DHA (2.65±0.041%) and eicosapentaenoic acid EPA (0.53±0.01). The DHA and EPA are highly valued polyunsaturated fatty acid (PUFA) and part of several health foods and nutraceuticals. Peroxidizability index calculated for the oil was 27.37% and unsaturated/saturated ratio was 3.25. High unsaturated fatty acid content signified its potential as a health promoter. Moreover, it can be expected to offer considerable resistance to oxidative rancidity during storage.
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