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Articles by M. Ahmed
Total Records ( 9 ) for M. Ahmed
  A. Hussain , S. Sasidharan , T. Ahmed , M. Ahmed and C. Sharma
  Cervical cancer is the second most common carcinoma in the world among women and is highly chemoresistant and radio resistant, often resulting in local treatment failure. For locally advanced disease, radiation is combined with low-dose chemotherapy; however, this modality often leads to severe toxicity. Prevention of cancer through dietary intervention recently has received an increasing interest, and dietary agents have become not only important potential chemopreventive, but also therapeutic agents when combined with chemotherapy or radiotherapy. In this study, we observed that gemcitabine was highly cytotoxic to both cancer and normal cells while clove extract (0.7-8 mg mL-1) was found to be comparatively more cytotoxic towards cancer cells. Notably, combination of low dose gemcitabine and ethanolic clove extract (2 and 3 mg mL-1) had more pronounced cytotoxic effect on cancer cells than single modalities. It is noteworthy that use of clove extract increased the efficacy of gemcitabine and importantly, it was found to be minimally toxic to normal cells. Together, these results suggest a novel mechanism may be involved in the synergistic effect of this combination.
  M.S. Hossain , M.R.I. Khan , A.S.M. Anisuzzaman , M. Ahmed , M.S. Amran and A. Islam
  Diabetes is a major public health problem. The development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. The antihyperglycemic activity of leaves of Mangifera indica was evaluated with scientific approaches. The study was undertaken to investigate the antihyperglycemic, Oral Glucose Tolerance Test (OGTT) and glycogenesis effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of Mangifera indica. The different extracts were administered intraperitoneally as a single dose of 150 mg kg-1 b.wt. to normal, glucose induced and alloxan induced diabetic rats and found to reduce blood glucose level significantly (p<0.05). Beside these, the different fractions of Mangifera indica to the alloxan-induced diabetic rats resulted in the significant elevation of liver glycogen content which was decreased by 50.60% in diabetic control. The effects of plant extracts were compared with standard drug metformin. The phytochemical screening tests indicate the different constituents such as triterpines, alkaloids, flavonoids etc. are present in the plant which have the antidiabetic property. Thus, this investigation paves the way for plant based diabetic treatment and indicates that various fractions (Petroleum ether, ethyl acetate and chloroform) of the ethanolic extract of Mangifera indica have favorable effect in bringing down the severity of diabetes as well as increase glycogenesis activity by increasing the cellular uptake of glucose.
  M. Ahmed , R. Jalil , M. A. Islam and S. M. Shaheen
  The investigation was carried out by the addition of variable percentages (0, 2, 4, 8 and 12%) of either Aluminum Stearate (AS) or Dioctyl Sodium Sulphosuccinate (DOSS) in Glycerol Monostearate (GMS)-based suppositories of Diclofenac Sodium (DS). DS suppositories of GMS base were prepared using AS and DOSS separately in different formulations by pour moulding method. Dissolution studies were carried out in USP Dissolution Tester using phosphate buffer (pH 7.4) as the dissolution medium maintaining the temperature at 37±2°C. The effects of AS and DOSS were evaluated on the release rate of DS from the GMS-based suppositories. The hydrophobic nature of GMS retarded the drug release markedly, while the inclusion of increasing percentage of AS and DOSS in GMS-based suppositories enhanced the release rate of DS to a considerable extent. Throughout the investigation, the release patterns in both cases were found to be square root of time dependent; indicating diffusion type of drug release. Formulation of DS suppositories with 12% DOSS gave sustained drug release profile. The stability studies of the DS suppositories containing 12% as well as DOSS have proved these formulations to be stable dosage forms.
  M. Ahmed , M.S.H. Molla and A.H.M. Razzaque
  The objective of this study was to see if it is possible to grow rice as a duel purpose crop i.e. as a source of green fodder and seed/grain. Results obtained from the experiment involving a) four leaf clipping heights viz. 10, 15, 20 cm and control (no clipping) and (b) four cultivars of rice viz. Latishail, BR10, BR11 and BRRIdhan32 revealed that green fodder yield decreased with the increase in height of leaf clipping. The lowest and highest green fodder yield were obtained from 20 and 10 cm clipping height, respectively. The identically highest green fodder yields were found by cultivars Latishail and BR11, respectively and the lowest by BRRIdhan32. Plant height was positively related to leaf clipping height. The highest and lowest plant heights at harvest were found in control (no clipping) and 10 cm clipping treatments, respectively. Hay yield and seed yield decreased with the decrease in height of leaf clipping. The lowest and highest yields of both hay and seed were obtained from 10 cm clipping height and control (no clipping), respectively. Clipping at 20 cm was statistically identical with control (no clipping) in respect of hay and seed yield. The highest hay and seed yields were found by cultivar BR11. It is possible to harvest rice green fodder from transplant aman rice like BR11 and the height of leaf clipping may be up to 20 cm at vegetative growth stage.
  M. Ahmed , M.A.Hashem , M.S.H.Molla and M.Kamruzzaman
  The possibility of extent usage of rice for human and livestock simultaneously was studied. The experiment consisted of four varieties namely Latishail, BR10, BR11 and BRRIdhan32 and four leaf cuttings viz., no leaf cutting(T1), leaf cutting at 21 DAT(T2), leaf cutting at 28 DAT(T3), leaf cutting at 35 DAT(T4). The effect of leaf cutting was significant on growth parameters namely plant height, total number of tillers and leaves hill –1 at different days after transplanting. In respect of all studied varieties, the highest plant height, total tillers hill –1, productive tillers hill –1 , non bearing tillers hill –1 , panicle length, grains panicle –1, sterile spikelets panicle –1,grain yield, straw yield, cumulative straw yield, biological yield and harvest index were obtained in no leaf cutting (control). The yield and yield contributing characters decreased by leaf cutting as compared to control. The results revealed that among the varieties and the different leaf cutting treatments, Latishail leaf cutting at 35 DAT gave the significantly higher forage yield. The highest grain yield was obtained in no leaf cutting which was statistically identical to leaf cutting at 21 and 28 DAT. It may be concluded that leaf cutting at early stage of crop growth could produce almost similar grain or seed yield of control crops with the additional forage yield.
  N. Ara , M.H. Nur , M.S. Amran , M.I.I. Wahid and M. Ahmed
  The research was conducted to investigate the in vitro antimicrobial and cytotoxic activities of leaves and flowers extract extracted from Lippia alba. Disc diffusion technique was used for in vitro antibacterial and antifungal screening. Zones of inhibition were observed in disc diffusion for antibacterial screening against 4 Gram-positive pathogenic and 6 Gram-negative pathogenic bacteria. Among crude extracts chloroform extract showed good activity against all test organisms. A Large zone of inhibition was observed (18 mm) against Vibrio parahaemolyticus. In antifungal screening, the compound showed mild to moderate zones of inhibition against four tested organisms. A Large zone of inhibition was observed against Aspergillus niger (13 mm). Cytotoxic activities of crude extracts were determined using Brine shrimp lethality Bioassay and LC 50 values of standard Vincristin sulphate as positive control, n-hexane and crude ethanol extracts were found to be 5, 15 and 20 μg mL-1, respectively.
  M. Ahmed , F. Ahmed , M.S.H. Molla , M.D. Hossain and B.M.Z. Rahman
  The experiment was conducted with three nitrogen levels (N1-50 kg N ha –1, N2-75 kg N ha–1, N3-100 kg N ha–1) and four times of leaf cutting (C0-no cutting, C1-cutting at 21 DAT-Day After Transplanting, C2-cutting at 35 DAT and C3-cutting at 49 DAT) to find the possibility of production of rice for green fodder as well as seed. Nitrogen levels exhibited their difference in almost all crop characters. The plant height, number of total tillers hill–1, green forage, forage dry matter, cumulative straw yield, number of productive tillers hill–1, number of non-bearing tillers hill–1, number of total spikelets panicle–1, number of grains panicle–1, number of sterile spikelets panicle–1, grain yield and straw yield were found to be highest with the highest level of nitrogen. Panicle length and 1000-grain weight did not vary with nitrogen levels. The values of these characters were found to be lowest with the lowest level of nitrogen (50 kg N ha–1). Harvest index was the highest at moderate level of nitrogen (75 kg N ha–1). Time of leaf cutting had significant influence on all the parameter studied. Plant height, number of total tillers hill–1, cumulative straw yield, number of productive tillers hill–1, number of non-bearing tillers hill–1, number of total spikelets panicle–1, number of grains panicle–1, number of sterile spikelets panicle 1, 1000-grain weight, grain yield and straw yield were found to be highest for no leaf cutting which was statistically similar to cutting at 21 DAT but 1000-grain weight was also similar to cutting at 35 DAT and lowest for cutting at 49 DAT. Amount of green forage and forage dry matter were highest for cutting at 49 DAT. It may be concluded that there is a tremendous possibility to get green forage and grain or seed from the same rice plant.
  M.Z. Alam , M. Ahmed , M.S. Alam , M.E. Haque and M.S. Hossin
  The experiment was carried out to investigate the effect of (a) three seedling ages viz. 21, 28 and 35 days and (b) four seedling raising techniques viz. normal wet, modified wet, floating and modified dapog on the yield and yield components of transplant aman rice cv. Binadhan 4. Except the number of non-effective tillers hill-1, weight of 1000-grains, harvest index and other characters were significantly influenced by both seedling ages and seedling raising techniques. Besides these, straw and biological yield showed non significant results in respect of seedling ages. The interaction between seedling ages and seedling raising techniques had significant effect on number of total tillers hill-1, number of effective tillers hill-1, grain, straw and biological yield.
  S. Kouser , M. Ahmed and S. Shah
  Wet bubble disease of white button mushroom (Agaricus bisporus) is the main constraint in the speedy development of this crop in the valley. The pathogen of this disease, is Mycogone perniciosa, which result either in the partial or total failure of the crop. The aim of the present study was to check the status and yield losses due to wet bubble disease of white button mushroom (Agaricus bisporus) at Mushroom Research and Training Centre of the SKUAST of Kashmir. In the present study, disease incidence, disease intensity and yield losses due to the pathogen were recorded in important mushroom units of Kashmir division, in order to check the frequency of prevalence of wet bubble disease. The survey revealed that wet bubble disease was prevalent in all mushroom growing districts in the range of 33.0 to 67.0%. With the overall mean disease incidence of 9.09% over years in three districts, the disease incidence was more (10.55-14.25%) in spring than in autumn season (3.61-8.05%). Similarly, the overall disease intensity was 17.82% over the years in these districts with more (16.86-28.31%) in spring than in autumn season (9.81-15.46%). The% yield loss over the years due to the disease ranged from 13.53 -22.41% with maximum loss reported in district Pulwama and minimum in district Srinagar. With an overall yield loss of 16.97% over the years, the loss was highest (15.88-26.01%) in spring than in autumn season (8.63-14.92%). The fungal pathogen constantly associated with the disease was established as Mycogone perniciosa. The pathogen produced typical and characteristic symptoms of wet bubble disease.
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