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Articles by M. Shamim Hossain
Total Records ( 7 ) for M. Shamim Hossain
  M.A. Awal , Ainun Nahar , M. Shamim Hossain , M.A. Bari , M. Rahman and M.E. Haque
  Present study assayed the toxicity effect of ethanolic leaf and seed extract of Cassia alata and found promising activity. From the probit transformation of resulting mortality data we got LC50 values of 4.31 ppm (μg mL-1) for seed and 5.29 ppm for leaf extract. Seed extract explored potent cytotoxicity similar to the standard gallic acid (LC50 = 4.53 ppm). From the antibacterial and MIC data it was evident that seed extract gave least activity against the tested bacteria whereas leaf extract deserved promising antibacterial activity.
  Chanmyia Sheikh , M. Shamim Hossain , Mst. Sabina Easmin , M. Saidul Islam , M. Aslam Hossain and Mamunur Rashid
  The aim of the present study was to investigate the biocidal activity of seven new chromium based coordination complexes [Cr(Pht)2 (Glycine)2, S1], [Cr(Pht)2 (Leucine)2, S2], [Cr(Pht)2 (Cystein)2, S3], [Cr(Pht)2 (Serine)2, S4], [Cr(Suc)2 (Leucine)2, S5], [Cr(Suc)2 (Cystein)2, S6] and [Cr(Suc)2 (Serine)2, S7] against Gram-positive and -negative bacteria, fungi and brine shrimp nauplii. The complexes S1, S3, S4, S6 showed good antibacterial activity at the concentration of 200 μg disc-1 and gave MIC values between 16-64 μg ml-1 against the tested bacteria. The complexes gave comparatively better antibacterial activity against the Gram-negatives. S2 did not show any remarkable antifungal activity but others showed good activity. The brine shrimp were hatched in artificial sea water and exposed to the complexes to determine mortality rate. LC50 values were calculated after probit transformation of the resulting data. All the complexes showed better cytotoxic effect but among them S1 and S3 having LC50 values of 3.31 and 3.63 μg ml-1 showed potent cytotoxic activity when compared with the reference standard Gallic acid whose LC50 values was 4.53 μg ml-1.
  Awal M.A , M. Shamim Hossain , M. Motiur Rahman and Mst. Shahnaj Parvin
  The root of Cassia tora exhibited substantial antishigellosis activity. The ethylacetate fraction of the crude extract showed maximum activity with the zone of inhibition ranging between 23-25 mm at the concentration of 200 μg disc-1. The minimum inhibitory concentration (MIC) of ethylacetate, chloroform and ethanol extracts was found between 32-64 μg ml-1 whereas the methanol and petroleum fractions showed MIC values between 128-512 μg ml-1. Thus the results suggest that the ethylacetate fraction may have some chemical constituents which could be useful as antishigellosis agents in modern clinical practice. Our effort is going on to isolate the potent antishigellosis constituents from the root extracts of Cassia tora with the aim of adding new therapeutic agents to fight against shigellosis problem in Bangladesh
  Mst. Sabina Easmin , M. Shamim Hossain , Chanmiya Sheikh , M.Saidul Islam , M. Anwarul Islam and Mamunur Rashid
  The aim of the present study was to investigate the antimicrobial and cytotoxic activities of four newly synthesized iron (III) based complexes [Fe(Suc)2(Phenylamine)2, F1], [Fe(Suc)2(Serine)2, F2], [Fe(Suc)2(Leucine)2, F3] and [Fe(Suc)2(Cystein)2, F4]. The complexes F1, F2, F3, F4 showed modest antibacterial and antifungal activities at the concentration of 200 μg disc-1 and gave MIC values between 16-64 μg ml-1 against the tested bacteria. Brine shrimp lethality bioassay was carried out for cytotoxicity measurements of the complexes and the LC50 values were calculated after probit transformation of the resulting mortality data. All the complexes showed lower cytotoxic properties compared with the reference standard gallic acid (4.53 μg ml-1) and bleomycin (0.41 μg ml-1).
  M. Ashraful Alam , Kudrat-e-zahan , M. Shamim Hossain and Fahmida Zerin Seema
  Three new cobalt μ-peroxo complexes [Co(2-apy)(O2)(OX), C1], [Co(2-apy)(O2)(2-ap), C2] and [Co(2-apy)(O2)(2-ab), C3] and two new zirconium μ-peroxo complexes [Zr(2-na)(O2)(OX), C5] and [Zr(2-ap)(O2)(OX), C5] were tested for their antibacterial activity by disc diffusion and serial dilution methods. All the coordination complexes were active against various test pathogenic organisms. The minimum inhibitory concentration (MIC) of the complexes was estimated between 32-64 μg ml-1 against Bacillus subtilis and Escharicha coli. The cytotoxicity of the five newly synthesized complexes was screened using brine shrimp lethality bioassay method and the LC50 values were calculated using probit analysis. LC50 values of the complexes C1-C5 were found 14.15, 9.12, 14.15, 29.51 and 5.75 7μg ml-1, respectively.
  M. Shamim Hossain , Kudrat-e-zahan , M. Anwar-ul-Islam , S. Sarkar , Jahanara Nassin , Aktarul Islam , M. Akhter Farooque and M. Asraful Alam
  Three coordination complexes of metals with mixed ligands [Mn(ED)(2-ap)2, A], [Fe(ED)(2-ab)2, B] and [Fe(ED)(2-ap)2, C] were tested for their antimicrobial activity by disc diffusion and serial dilution methods. All the complexes were active against various test pathogenic organisms. The maximum antibacterial and antifungal activities were shown by the manganese complex A. The minimum inhibitory concentration of the complex A was determined against four pathogenic bacteria Bacillus subtilis, Streptococcus-β-haemolyticus,Escherichia coli and Salmonella typhi and values were found between 16-32 μg ml-1. The manganese complex A also showed potent cytotoxic effect which is indicative of its probable effect on cancer cell lines.
  M.H. Morshed , M. Shamim Hossain , M. Ibrahim , M.Z. Shafique , M.O.H. Helali , A. Samad , M.S. Islam and M.A. Islam
  The aim of the present study was to evaluate the antibacterial characteristic of the four synthetic plant hormones Indoleacetic acid (IAA), 2,4- dichlorophenoxyacetic acid (2,4-D), Naphthaleneacetic acid (NAA) and Gibberellic acid (GA). Antibacterial potency was assessed by measuring the zone of inhibitions on semi-solid nutrient agar bacterial inoculating petri dishes. NAA and IAA gave potent antibacterial activity at concentration of 150 μg disc-1 giving zones at 26-35 mm. Bacteriostatic and bactericidal concentrations against the pathogens were determined by serial dilution technique. Bacteriocidal concentrations of the tested principles were found to be significantly higher than their respective bacteriostatic concentrations. Minimum inhibitory concentrations that are bacteriostatic concentrations of the tested compounds were found at 32-128 μg mL-1 whereas, bactericidal concentrations established at 256-512 μg mL-1 against eight pathogenic bacteria Streptococcus -haemolyticus, Staphylococcus aureus, Pseudomonas aeroginosa, Shigella dysenteriae, Shigella flexneri, E. coli, Salmonella typhi and Klebsiella pneumoniae.
 
 
 
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