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Articles by M. Obayed Ullah
Total Records ( 4 ) for M. Obayed Ullah
  M. Obayed Ullah , T. Shrestha , T. Sirajam Munira and M.S.K. Choudhuri
  In this study, the pharmacological and toxicological effects along with possible side effects of the classical ayurvedic formulation “Lauhasava” (LSV), which is used in anemia, were evaluated. During this study, various experiments on body growth rate, organ-body weight ratio, tissue hydration indices and body fat ratio were performed to evaluate its efficacy and toxicity. In the body weight study, the LSV treated rats, irrespective of sexes, showed significantly lower body weights than the control group rats. LSV treated mice of both sexes gained less weight than their control counterparts. The study involving comparison of the relative weights of the major organs of rats and mice revealed some significant results. The percentage of lung to the body weight is significantly increased in both sexes of rats. Liver weight in LSV treated rats of both sexes were observed to be increased. The percentage of kidney weight was increased in both sexes of rats, the result being significant in the case of female rats. The thymus weight was found significantly decreased in both sexes of rats. Significant increase in the weight of rats` ovaries was observed. In the tissue hydration index experiment, only the increase in the female kidney was significant. No significant result was found in the fat content of the whole mice and eviscerated mice.
  M. Obayed Ullah , M. Jashim Uddin , K. Hamid , S. Kabir , M. Azizur Rahman and M.S.K. Choudhuri
  The study was carried out to investigate the safety profile as well as the effect of “Rohitakarista” (RHT) on various biochemical parameters of rats` plasma after chronic administration. RHT, a classical Ayurvedic preparation used in hepatosplenic disorders, was administered per oral route at a dose of 100 mg kg-1 body weight, once daily, up to 46 days for all the experiments. Forty albino rats (Rattus novergicus: Sprague-Dawley strains), equally of both sexes, were randomly grouped into four where each group had ten animal/sex. One male and one female group were used as control and other groups were used as test. In the male, rats there was a statistically insignificant increase (p = 0.763) in the total protein but there was a statistically significant increase (p = 0.022) in the total protein content of the plasma of female rats. Statistically very high significant increase (male: p = 0.001 and female: p = 0.001) in the albumin content of the plasma was noted in both sexes. In case of bilirubin, interestingly it was decreased very high significantly (p = 0.001) in plasma of male rats but increased very high significantly (p = 0.001) in the plasma of female rats. In the male rats, statistically there was a very high significant decrease (sGPT: p = 0.001, sGOT: p = 0.001 and ALP: p = 0.001) in the sGPT, sGOT and ALP activities in the plasma. On the other hand, statistically there was a very highly significant increase (sGPT: p = 0.001, sGOT: p = 0.001 and ALP: p = 0.001) in the sGPT, sGOT and ALP activities in the plasma of female rats. Very high significant decrease (male: p = 0.001 and female: p = 0.001) in creatinine in plasma of both sexes were observed after chronic administration of RHT. Urea in the plasma was decreased very high significantly (p = 0.001) in plasma of male rats but increased very high significantly (p = 0.001) in the plasma of female rats. There was high significant increase (p = 0.002) in uric acid in male rats. On the contrary, no significant increase (p = 0.324) of uric acid was observed in female rats.
  M. Haque , M. Obayed Ullah and K. Nahar
  Crude extracts from different parts (leaf, bark and seed) of Swietenia mahagony (Family: Meliaceae) were screened for their antibacterial activity against 4 Gram positive and 8 Gram negative bacteria. Disc diffusion technique was used for in vitro screening. Among the crude extracts, chloroform and ethyl acetate extracts of leaf and bark showed good activity against all the tested organisms. The chloroform and ethyl acetate extracts of seed exhibited little or positive effect against most of the tested bacteria. The activities were compared to a standard antibiotic-kanamycin. Cytotoxic activity of crude extracts were determined using brine shrimp lethality bioassay and standard vincristine sulphate was used as positive control. The chloroform extract of seed and ethyl acetate extract of bark showed good cytotoxic activities and the LC50 values were found 13.75 and 11.64 μg mL-1, respectively.
  N. Krishna Kundu , M. Obayed Ullah , Kaiser Hamid , Kaniz Fatima Urmi , Israt Jahan Bulbul , Muhammad Atikul Islam Khan , Momita Akter and M.S.K. Choudhuri
  The successful use of Ayurvedic medicines is for many years but there is no guideline for studying the toxicity of these preparations through preclinical or clinical investigations. The present study was conducted to evaluate the effect of conventionally prepared Sulavajrini Vatika (SBB), an Ayurvedic formulation on various biochemical parameters of experimental animals after chronic administration. The animal used was albino rats (Rattus norvegicus: Sprague-Dawley strain) and SBB was administered orally at a single dose of 100 mg kg-1 b.wt. day-1, up to 62 days. During the study, forty rats, equally of both sexes, were randomly grouped into four where one male and one female group were used as control and other groups were used as test. Among the lipid components, Triglyceride (TG) was decreased very high significantly in both sexes of animal. The decrease of Total Cholesterol (TC), Very Low Density Lipoprotein (VLDL) and high-density lipoprotein (HDL) were also highly significant. Low Density Lipoprotein (LDL) decreased in all SBB treated group. In the liver function parameters, the total protein and albumin content were increased very high significantly in both sexes of rat. But the bilirubin was decreased insignificantly in male and female rats. Serum Glutamic Pyruvic Transaminase (GPT), Glutamic Oxaloacetic Transaminase (GOT) and Alkaline Phosphatase (ALP) were decreased in all treated animals and it was very high significant. In case of kidney function parameters, creatinine was increased very high significantly but the urea was decreased very high significantly in both sexes of rat. The decrease in uric acid was not significant in none of the sexes of rat. The present study confirms that SBB can be contributory for the complications in diabetics with hyperlipidemia and nephropathy as it lowers most of the lipids components and improves liver function and kidney function parameters.
 
 
 
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