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Articles by M. Mostofa
Total Records ( 9 ) for M. Mostofa
  S.M.A. Khalid , M.R. Amin , M. Mostofa , M.E. Choudhury and B. Uddin
  Abstract: The experiment was conducted in the Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, for a period of 28 days to study the effects of indigenous medicinal plants (neem and pineapple) against gastro-intestinal nematodiasis in sheep. The sheep is the source of animal protein, hide, meat and milk. Parasitism is a serious problem of livestock where nutrition and sanitation are poor. In Bangladesh, gastro-intestinal nematodiasis causing a significant economic loss as a result of animal diarrhoea, stunted growth, decreased milk production, emaciation, loss of working ability and even death. Fifteen sheep were selected from fifty five sheep for this study which was heavily infected with gastro-intestinal nematodes marked by McMaster method. Sheep were treated with neem and pineapple (10% water extract of leaves). A significant (p < 0.01) reduction of EPG count was found on 7th, 14th, 21st and 28th day of neem (47.03, 46.27, 41.82 and 37.60%) and pineapple (41.13, 39.27, 36.32 and 32.18%) treated sheep. The EPG count of untreated control group were significantly (p < 0.01) increased about 7.88, 11.45, 20.15 and 30.26% on 7th, 14th, 21st and 28th day, respectively. After treatment with neem and pineapple, Total Erythrocyte Count (TEC), Hemoglobin (Hb) content and Packed Cell Volume (PCV) were increased significantly (p < 0.01 and p < 0.05) in sheep. On the other hand Total Leukocyte Count (TLC) was decreased significantly (p< 0.01 and p < 0.05) in all treated sheep. The body weight was increased significantly (p < 0.01 and p < 0.05) in neem and pineapple treated sheep. On the other hand body weight was decreased in untreated control group. Neem and pineapple (10% water extract of leaves) may be used as moderate anthelmintics against gastro-intestinal nematodiasis in sheep.
  M.W. Rahman , M. Mostofa , S.A. Sardar , M.R. Sultana , M.M. Haque and M.E. Choudhury
  The experiment was conducted to compare the hypoglycemic efficacy of Neem, Karala and Nayantara with that of Glibenclamide on normal rat. In addition to that the experiment was conducted to compare the effects on body weight of rat after administration of those drugs. After 14 days during treatment with those drugs following observation were made (1) Neem when administered orally @ 500 mg kg-1 b.wt. significantly (p>0.01) decreased blood glucose level (7.52 to 3.98 mol L-1) and body weight also significantly (p<0.01) increased (153.20 to 155.80 mg kg-1) (2) Karala when administered orally @ 200 mg kg-1 b.wt. significantly (p>0.01) decreased blood glucose level (8.96 to 4.82 mol L-1) and body also significantly (p<0.01) increased (169.20 to 177.20 mg kg-1) (3) Nayantara when administered orally @ 500 mg kg-1 b.wt. significantly (p>0.01) decreased blood glucose level (6.80 to 4.44 mol L-1) and body also significantly (p<0.01) increased (120.40 to 140.40 mg kg-1) and Glibenclamide when administered orally @ 0.25 mg kg-1 b.wt. significantly (p>0.01) decreased blood glucose level (7.20 to 6.61 mol L-1) and body also significantly (p<0.01) increased (164.00 to 171.40 mg kg-1). From this experiment it is concluded that Neem (Azadirachta indica), Karala (Momordica charantia) and Nayantara (Cathranthus roseus) is potent hypoglycemic agent as Glibenclamide.
  M.R. Amin , S.M.A. Khalid , M.O. Alam , M. Mostofa , B. K. Paul and M. Shahiduzzaman
  The research work was carried out to investigate the effects of Helmex? and Peraclear? against gastro-intestinal nematodiasis in sheep. The effects of Helmex? and Peraclear? on clinical parameter (body weight) and some haematological parameters (TEC, Hb, PCV and TLC) in sheep were also determined in this study. Fifteen sheep were selected from fifty five sheep for this study which was heavily infected with gastro-intestinal nematodes marked by McMaster method. Out of three groups of sheep (each containing 5 sheep), one group was kept as control. Another two groups of sheep received separately Helmex? (albendazole, @ 15mg/kg body weight orally, Renata Limited, Bangladesh) and Peraclear? (fenbendazole, @ 5 mg/kg body weight orally, Techno Drugs Limited, Bangladesh). A significant (p<0.01) reduction of EPG count were found on 7th, 14th, 21st and 28th day of Helmex? (83.61%, 82.35%, 79.73% and 77.25%) treated sheep. Significant (p<0.01) reduction of EPG count were also found on 7th, 14th, 21st and 28th day of Peraclear? (84.41%, 83.77%, 81.74% and 79.53%) treated sheep. The EPG count of untreated control group were significantly (p<0.01) increased about 7.88%, 11.45%, 20.15% and 30.26% on 7th, 14th, 21st and 28th day respectively. The EPG count of untreated control group were significantly (p<0.01) increased about 7.88%, 11.45%, 20.15% and 30.26% on 7th, 14th, 21st and 28th day respectively. After treatment with Helmex? and Peraclear?, total erythrocyte count (TEC), haemoglobin (Hb) content and packed cell volume (PCV) were increased significantly (p<0.01 and p<0.05) in sheep. On the other hand total leukocyte count (TLC) was decreased significantly (p<0.01 and p<0.05) in Helmex? and Peraclear? treated sheep. The body weight was increased significantly (p<0.01 and p<0.05) in Helmex? and Peraclear? treated group. On the other hand body weight was decreased in untreated control group. Helmex? and Peraclear? may be used as a broad spectrum anthelmintic against gastro-intestinal nematodiasis in sheep.
  Ahmed, S. , M. A. Awal , M. M. Rahman and M. Mostofa
  Comparative efficacy of neem and karela with insulin and glibenclamide was studied on some lipid profile(total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol) in 40 rabbits from February to April, 2003. Rabbits were randomly divided into 8 equal groups and rabbits of group A and B were kept as non hyperglycemic control and hyperglycemic control respectively. Hyperglycemia was induced in 7 groups of rabbits (B, C, D, E, F, G and H) by administering alloxan at a dose of 200 mg/ kg body wt. s/c. After 15 days of alloxan injection, 6 groups of rabbits (C, D, E, F, G and H) were treated with insulin, glibenclamide, neem seed kernel powder (NP), neem seed oil (NSO), neem leaf extract (NLE) and karela fruit juice (KFJ) at the dose rate of 5 U/kg, 0.5 mg/ kg., 500 mg/kg , 1 ml/kg , 500 mg/ kg and 100 mg/kg body weight respectively for consecutive 28 days. All the control and treated rabbits were closely observed during pre-treatment, 28 days of treatment and also for 14 days of post-treatment period and the lipid profile was investigated. Due to alloxan induced diabetes the content of total cholesterol increased significantly (P<0.01) in all groups except the normal control group A. On 28th day of treatment period the amount of total cholesterol, serum triglyceride, HDL cholesterol and LDL cholesterol were significantly(P<0.01) reduced to extent of 15-30%, 15-46%, 15-25% and 16-32% respectively that were close to the initial value before the commencement of dosing(day 0) except with KFJ which had very little effect(15%). Glibenclamide reduced the triglyceride level to a greater extent (46%) than other drugs. Insulin and glibenclamide showed similar efficacy (25%) in reduction of the serum HDL cholesterol level and (31-32%) in LDL cholesterol level. It was observed that patent drugs insulin and glibenclamide induced better and almost equal efficacy in reducing the parameters whereas herbal preparations of neem, i.e., NP, NSO and NLE showed almost equal but less efficacy than two patent drugs and Karela fruit juice was found to be least effective. It may be concluded that instead of less efficacy than patent drugs, the efficacy of neem and karela was also encouraging.
  S. Ahmed , M. A. Awal , M. M. Rahman and M. Mostofa
  Comparative efficacy of neem and karela with insulin and glibenclamide was studied on some biochemical parameters (Blood glucose, Serum urea and Serum creatinine) in 40 rabbits from February to April, 2003. Rabbits were randomly divided into 8 equal groups and rabbits of group A and B were kept as non hyperglycemic control and hyperglycemic control respectively. Hyperglycemia was induced in 7 groups of rabbits (B, C, D, E, F, G and H) by administering alloxan at a dose of 200 mg/ kg body wt. s/c. After 15 days of alloxan injection, 6 groups of rabbits (C, D, E, F, G and H) were treated with insulin, glibenclamide, neem seed kernel powder (NP), neem seed oil (NSO), neem leaf extract (NLE) and karela fruit juice (KFJ) at the dose rate of 5 U/kg, 0.5 mg/ kg., 500 mg/kg , 1 ml/kg , 500 mg/ kg.and 100 mg/kg body weight respectively for consecutive 28 days. All the control and treated rabbits were closely observed during 28 days of treatment and also for 14 days of post-treatment period and biochemical parameters were investigated. Blood glucose levels were significantly (P<0.01) reduced in all treated six groups of rabbit to the extent of 25-42% in comparison to their pre-treatment values. Similarly, serum urea and creatinine values were reduced significantly (P<0.01) to the extent of 15-25% and 4-15% respectively on 28th day of treatment in comparison to their 21th day treatment values. It was also observed that patent drugs insulin and glibenclamide induced better and almost equal efficacy in reducing the parameters whereas herbal preparations of neem, i.e., NP, NSO and NLE showed almost equal but less efficacy than two patent drugs and Karela fruit juice was found to be least effective. It may be concluded that instead of less efficacy than patent drugs, the efficacy of neem and karela was also encouraging.
  P. K. Das , M. Mostofa , Q. Hasan , G. C. Shil and M. R. Islam
  The research work has conducted in 4 groups (each containing of 5 mice) of swiss albino mice following oral administration of H2-blockers and proton pump inhibitor (Ranitidine, Famotidine and Omeprazole) at the dose rate of 100 mgkg-1. b. wt. 13.33 mgkg-1. b. wt. and 3.33 mgkg-1 b. wt., respectively to investigate the toxic as well as gross pathological changes and also to estimate the blood glucose level. Loose faeces were found in group B (Ranitidine) during last few days of experimental period. Following post-mortem examination, congestion and pale colour of the liver was found in group C and D respectively. In the treatment group B (Ranitidine), TEC, TLC, Hb%, Monocyte, Neutrophil and Eosinophil count were significantly decreased whereas Lymphocyte was significantly increased in the same treatment group. The highest decrease in TEC (16.08%), TLC (17.77%), Hb% (20.75%), Monocyte (33.33%), Neutrophil (26.31%), Eosinophil (33.33%) was recorded. In the treatment group C (Famotidine), TLC, Monocyte count, blood level serum were significantly decrease whereas Lymphocyte count was significantly increased in the same treatment group. The highest decrease of TLC (17.41%), blood glucose (36.67%), Monocyte count (41.66%) was recorded. The highest increase of Lymphocyte was also recorded. In the treatment group D (Omeprazole), TLC, Monocyte count, blood glucose level were significantly decreased whereas Lymphocyte and neutrophil count was significantly increased. The highest decrease of TLC (23.28%) and Monocyte count was also recorded.
  M.M. Haque , K. Rafiq , S.J. Sherajee , S. Ahmed , Q. Hasan and M. Mostofa
  The present investigation was carried out in 40 guinea pig with the aim to investigate the efficacy of some indigenous medicinal plants in the treatment of external wounds. Two wounds of 2.00 cm length and 0.5 cm depth were made on the opposite thigh muscles and the effects of some antibacterial and some indigenous medicinal plants leaves were observed separately. Among the antibacterial used in this studies comparatively Nebanol powder showed the best result and was more effective for the treatment of fresh wounds in which healing occurred with in 11 days, Where as it was taken 13 days for sulfanilamide powder and 15 days for dusting powder treated groups. In the present experiment the leaves of the Neem, Ganda, Mehedi and raw Halid were applied as fresh aqueous pastes for the treatment of artificially produce wound in guinea pig. In comparison to their effect, Neem leaves paste showed the more effectiveness where healing was completed on 15 days, Halud paste and Ganda leaves pastes showed the same results, where healing was completed on 17 days. The Mehedi paste was the least effective in which healing occurred on 19 days. This investigation suggested that Neem leaves fresh paste are more effective for wound healing in guinea pig which may be suggested for the treatment of fresh wound healing of other livestock.
  M.R. Amin , M. Mostofa , K. Rafiq , M.S. Hossain , M.M. Hasan and M.L. Sharmin
  The research work was carried out to investigate the effects of oral administration of glucocorticoids (dexamethasone and prednisolone), NSAIDs (aspirin and paracetamol) and sulfonylureas (gliclazide and glibenclamide) on body weight and blood glucose in mice. Out of seven groups of mice (each containing 5 mice), one group was kept as control without giving any drug. Another six groups of mice received separately dexamethasone (Oradexon®, 3.5 mg kg-1 b.wt.) prednisolone (Deltasone®, 8 mg kg-1 b.wt.), aspirin (Ecospirin®, 620 mg kg-1 b.wt.), paracetamol (Napa®, 333 mg kg-1 b.wt.), gliclazide (Comprid®, 64 mg kg-1 b.wt.) and glibenclamide (Glucotab®, 16 mg kg-1 b.wt) orally along with normal feed. A significant (p<0.05) reduction of body weight was recorded on 7th day following administration of dexamethasone, gliclazide and glibenclamide in mice. This reduction was highly significant (p<0.01) on 21st, 42nd and 70th day following dexamethasone, gliclazide and glibenclamide treated groups. Similarly prednisolone significantly (p<0.01) reduced body weight of mice in whole experimental period. A significant (p<0.01) increase of the blood glucose level was found due to dexamethasone, prednisolone, aspirin and paracetamol administration on 7th , 21st, 42nd and 70th day. On the other hand, a significant (p<0.01) decrease of blood glucose level was found in mice treated with gliclazide and glibenclamide in whole experimental period. It may be concluded that oral administration of glucocorticoids, NSAIDs and sulfonylureas have variable effects on blood glucose level in mice.
  S.M.A. Khalid , M.R. Amin , M. Mostofa , M.J. Hossain and M.A.K. Azad
  The present study shows that the overall prevalence of gastro-intestinal nematodes in sheep was 58.18% in Mymensingh. Sheep were infested with Strongyloides spp. (7.7%), Haemonchus spp. (18.18%), Trichuris spp. (5.45%), Oesophagostomum spp. (9.09%) and mixed infection (14.18%). Twenty sheep were selected from fifty five sheep for this study which was heavily infected with gastro-intestinal nematodes marked by McMaster method. Sheep were treated with Vermic® (ivermectin) @ 0.23 mg kg-1 body weight. A significant (p<0.01) reduction of EPG count was found on 7th, 14th, 21st and 28th day of Vermic® (90.51, 89.85, 87.91 and 86.38%) treated sheep. The EPG count of untreated control group were significantly (p<0.01) increased about 7.88, 11.45, 20.15 and 30.26% on 7th, 14th, 21st and 28th day, respectively. After treatment with Vermic®, Total Erythrocyte Count (TEC), Hemoglobin (Hb) content and Packed Cell Volume (PCV) were increased significantly (p<0.01 and p<0.05) in sheep. On the other hand Total Leukocyte Count (TLC) was decreased significantly (p<0.01 and p<0.05) in all treated sheep. The body weight was increased significantly (p<0.01 and p<0.05) in Vermic® treated group. On the other hand body weight was decreased in untreated control group. Vermic® may be used as a broad spectrum anthelmintic against gastro-intestinal nematodiasis in sheep.
 
 
 
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