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Articles by M. Mamman
Total Records ( 2 ) for M. Mamman
  S. Adamu , M.Y. Fatihu , N.M. Useh , N.D.G. Ibrahim , M. Mamman , V.O. Sekoni and K.A.N. Esievo
  In order to investigate whether testicular pathologic changes reported in trypanosome-infected animals are related to declining testosterone concentrations or not, four White Fulani bulls (infected group) with similar ages and weights were infected with Trypanosoma vivax (T. vivax), Kudaru stock, by inoculating each, intravenously, with 2 mL of blood from an infected donor calf containing 2106 T. vivax organisms. Three other White Fulani bulls, with ages and weights similar to those of the infected group, which were uninfected, served as control group. Blood samples were collected from animals in the two groups before and after the infection to determine Packed Cell Volume (PCV) and serum testosterone profile. To carry out histopathological studies on the testes and other organs in the body of these animals, one bull from the infected group was sacrificed on day 14 Post-Infection (PI), while two bulls (one each from the infected and control groups) were sacrificed, each, on days 28, 56 and 84 PI. All animals in the infected group were parasitaemic by day 6 PI. This was followed by a gradual and progressive decrease in the values of Packed Cell Volume (PCV) and serum testosterone concentrations in these animals. PI values of these parameters in the control group remained normal relative to the pre-infection ones. The mean PI testosterone concentrations, measured in ng mL 1, in individual bulls of the infected group sacrificed on days 14, 28, 56 and 84 were 9.6±4.2, 7.8±3.7, 4.9±4.1 and 5.0±3.4, respectively. Histopathologically, severe testicular degeneration was observed in all animals in the infected group characterized by necrosis and depletion of the spermatogenic and sertoli cells in the seminiferous tubules. Leydig cells in the interstitial tissues of the testes were also severely degenerated. Severity of the lesions was related to serum testosterone concentrations as testicular degeneration was progressive from the bull that was sacrificed on day 14 PI moving through to the bull that was sacrificed on day 56 PI which had the least mean PI testosterone concentration and in which both spermatogenic and sertoli cells had undergone karyolysis and so were completely depleted. In contrast, testes of bulls in the control group were normal as both seminiferous tubules and interstitial tissues of the testes contained full complement of the spermatogenic and Leydig cells, respectively. It is concluded from this study that lowering testosterone concentration may be an aggravating factor to the degenerative changes observed in the testes of trypanosome-infected male animals.
  S.F. Ambali , M. Mamman , A.O. Adaudi , K.A.N. Esievo , J.O. Ayo and M.S. Abubakar
  The aim of this study is evaluate the curative and protective effects of penicillin G in mice poisoned with the lyophilized extract of Chlorophyllum molybdites. Fifty Swiss albino mice were divided into 5 groups of 10 mice each. Mice in group 1 were pretreated with penicillin G at 38, 280 IU kg-1, i.p. and then dosed with LD99 of C. molybdites (741 mg kg-1) i.p., mice in group 2 were dosed with the extract and then treated with penicillin G, while mice in group 3 were dosed with the extract only. Mice in groups 4 and 5 were dosed with penicillin G and physiological saline solution, respectively. The mice were monitored for clinical signs of toxicity, pathological lesions and death over a period of 72 h. The mean time of death in mice from penicillin-treated groups 1 and 2 were compared with those in the extract-treated group using one-way analysis of variance (ANOVA) and values of p<0.05 were considered significant. The result showed a significant reduction in the severity of clinical signs and mortality in penicillin-treated groups 1 and 2 compared to the group dosed with only the extract. There was a significant difference in the mean time of death in mice from groups 1, 2 and 3. However, there was no reduction in the severity of lesions in mice from groups 1 and 2 treated with penicillin G compared with extract-treated group. Therefore, this study has shown that penicillin G has significant curative and protective effects in mice poisoned with the lyophilized extract of C. molybdites. This result may prove useful in the treatment of humans and animals suffering from C. molybdites poisoning.
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