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Articles by M. Lawal
Total Records ( 4 ) for M. Lawal
  Y. Saidu , L.S. Bilbis , M. Lawal , S.A. Isezuo , S.W. Hassan and A.Y. Abbas
  The current study reports the toxicological studies of the crude aqueous leaf extract using albino rat models. The in vivo effects of acute and sub-chronic doses of the extract on liver function and kidney function parameters were studied. The results indicated that the LD50 of the extract is > 3000 mg kg-1 body weight. There were no significant differences (p>0.05) in weight changes of the animals on different doses of the extract during both the acute and sub-chronic toxicity tests. The biochemical parameters of the animals on different doses of the extract were not significantly (p>0.05) different, except the ALT and AST that, in non-dose dependence, showed significant differences (p<0.05) in both test models. Serum globulin level of the animals on different doses during the sub-chronic test was also significantly different (p<0.05). These results indicated that the crude extract of A. chevalieri may be relatively safe for human consumption.
  S.W. Hassan , R.A. Umar , M. Lawal , L.S. Bilbis , B.Y. Muhammad , U.Z. Faruk and A.A. Ebbo
  The alkaloidal composition, histopathological and toxicity studies of alkaloid and aqueous ethanol extracts of Boscia angustifolia on biochemical indices of kidney and liver functions in rats were studied. The amount of alkaloids detected in 50 g powdered root extract of the plant was 11.44% (w/v). Renal and liver indices were significantly (p<0.05) altered at higher doses of 703.60, 1125.70 (alkaloidal extract), 839.30 and 1342.80 mg kg-1 body weight (aqueous ethanol extract). The aqueous ethanol and alkaloidal root extracts produced histopathological lesions of the liver and kidney at higher doses. These lesions include perivascular cuffs, protein cast, infiltration (kidney) and slight infiltration and perivascular cuffs (liver). There was a significant (p<0.05) dose dependent decrease in weight in the rats given higher doses of the aqueous ethanol and alkaloidal root extracts of Boscia angustifolia. The use of this plant is associated with some levels of organ toxicity.
  S.W. Hassan , R.A. Umar , M.J. Ladan , P. Nyemike , R.S.U. Wasagu , M. Lawal and A.A. Ebbo
  This study was aimed to assess the nutritive value, phytochemical constituents and antifungal activity of leaf, root and stem extracts of Pergularia tomentosa. Chemical composition of leaf, stem and root extracts of the plant were determined using standard methods. Aqueous and organic solvents extracts of the plant parts were screened for antifungal activity using agar dilution method. Phytochemicals detected in the leaf and stem extracts were alkaloids, cardiac glycosides, cyanogenic glycosides, saponins, flavonoids, tannins and anthraquinones. The roots contain trace amounts of cyanogenic glycosides, cardiac glycosides, saponins, tannins and anthraquinones. Mineral element composition of the plant showed higher amount of phosphorus and potassium in the root and stem and sodium, magnesium and calcium in the leaf extracts. All the plant parts used contain high percentages of carbohydrates and crude fibre ranging from 53.27±1.75 to 61.31±2.84% and 16.33±0.29 to 23.17±0.58%, respectively. Lipids (6.83±0.76%), ash (17.17±1.04%) and crude protein contents (6.39±0.17%) were higher in the leaf extracts while the stem was of higher moisture (10.67±0.76%) content. Hexane (HX), Petroleum Ether (PE) and chloroform (CHL) leaf, stem and root extracts were active against all the isolates tested with percentage inhibitions ranging from 41.90±5.63 to 97.52±0.28%. The organic solvent extracts demonstrated near complete inhibitions of the fungal isolates at 8.00 mg mL-1 while the aqueous (AQ) extracts of the plant parts inhibited the growth of the isolates at 27.17±7.79 to 97.45±0.21% with near complete inhibition of the tested isolates also at 8.00 mg mL-1. The results showed that the leaf, root and stem extracts of Pergularia tomentosa have potential nutritional and antifungal uses.
  Y. Saidu , M. Lawal , S.A. Isezuo , R.A. Shehu , D.M. Sahabi and L.S. Bilbis
  This research studied the hypoglycaemic effect of aqueous leaf extract of Albizzia chevalieri in alloxan-induced diabetic albino rats, using activity-guided fractionation. Preliminary elucidation of the mechanism of hypoglycaemic activity was also studied. The crude aqueous leaf extract of the plant (100 mg kg-1 body weight) reduced blood glucose levels of both the diabetic and normal rats by about 30%. The hypoglycaemic agent(s) were fractionated in the hexane fraction of the aqueous extract and partitioned in the second elution fraction (H2) by column chromatography. Thin layer chromatography of H2 gave a single spot with water as the mobile phase. The preliminary results of the mechanism of action indicated that the extract did not affect the in vivo digestion of carbohydrate or intestinal absorption of glucose. It however caused significant (p<0.05) increase in the hepatic and extrahepatic glycogen store. Phytochemical screening of the crude extract indicated the presence of saponins, flavonoids, tannins, terpenes, steroids, balsams, glycosides and alkaloids. UV/visible spectral studies of H2 indicated a λmax of 320 nm. These results suggest that the hypoglycaemic effect of the extract is as a result of induction of glycogenesis.
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